data_16027
#######################
# Entry information #
#######################
save_entry_information
_Entry.Sf_category entry_information
_Entry.Sf_framecode entry_information
_Entry.ID 16027
_Entry.Title
;
ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
;
_Entry.Type macromolecule
_Entry.Version_type original
_Entry.Submission_date 2008-11-07
_Entry.Accession_date 2008-11-07
_Entry.Last_release_date .
_Entry.Original_release_date .
_Entry.Origination author
_Entry.NMR_STAR_version 3.1.1.61
_Entry.Original_NMR_STAR_version 3.0.8.116
_Entry.Experimental_method NMR
_Entry.Experimental_method_subtype solution
_Entry.Details .
_Entry.BMRB_internal_directory_name .
loop_
_Entry_author.Ordinal
_Entry_author.Given_name
_Entry_author.Family_name
_Entry_author.First_initial
_Entry_author.Middle_initials
_Entry_author.Family_title
_Entry_author.Entry_ID
1 Q. Hua Q. X. . 16027
2 B. Xu B. . . 16027
3 K. Huang K. . . 16027
4 S. Hu S. Q. . 16027
5 S. Nakarawa S. . . 16027
6 W. Jia W. H. . 16027
7 N. Philips N. F.Phil . 16027
8 L. Wittaker L. . . 16027
9 J. Wittaker J. . . 16027
10 P. Katsoyannis P. G. . 16027
11 M. Weiss M. A. . 16027
stop_
loop_
_SG_project.SG_project_ID
_SG_project.Project_name
_SG_project.Full_name_of_center
_SG_project.Initial_of_center
_SG_project.Entry_ID
. 'not applicable' 'not applicable' . 16027
stop_
loop_
_Struct_keywords.Keywords
_Struct_keywords.Text
_Struct_keywords.Entry_ID
HORMONE . 16027
INSULIN . 16027
MUTANT . 16027
stop_
loop_
_Data_set.Type
_Data_set.Count
_Data_set.Entry_ID
assigned_chemical_shifts 1 16027
stop_
loop_
_Datum.Type
_Datum.Count
_Datum.Entry_ID
'1H chemical shifts' 320 16027
stop_
loop_
_Release.Release_number
_Release.Format_type
_Release.Format_version
_Release.Date
_Release.Submission_date
_Release.Type
_Release.Author
_Release.Detail
_Release.Entry_ID
2 . . 2009-05-18 2008-11-07 update BMRB 'complete entry citation' 16027
1 . . 2009-04-17 2008-11-07 original author 'original release' 16027
stop_
loop_
_Related_entries.Database_name
_Related_entries.Database_accession_code
_Related_entries.Relationship
_Related_entries.Entry_ID
BMRB 16026 'INSULIN A CHAIN, INSULIN B CHAIN (mutant)' 16027
PDB 2K91 'BMRB Entry Tracking System' 16027
stop_
save_
###############
# Citations #
###############
save_citations
_Citation.Sf_category citations
_Citation.Sf_framecode citations
_Citation.Entry_ID 16027
_Citation.ID 1
_Citation.Class 'entry citation'
_Citation.CAS_abstract_code .
_Citation.MEDLINE_UI_code .
_Citation.DOI .
_Citation.PubMed_ID 19321436
_Citation.Full_citation .
_Citation.Title 'Enhancing the activity of a protein by stereospecific unfolding. The conformational life cycle of insulin and its evolutionary origins'
_Citation.Status published
_Citation.Type journal
_Citation.Journal_abbrev 'J. Biol. Chem.'
_Citation.Journal_name_full .
_Citation.Journal_volume 284
_Citation.Journal_issue 21
_Citation.Journal_ASTM .
_Citation.Journal_ISSN .
_Citation.Journal_CSD .
_Citation.Book_title .
_Citation.Book_chapter_title .
_Citation.Book_volume .
_Citation.Book_series .
_Citation.Book_publisher .
_Citation.Book_publisher_city .
_Citation.Book_ISBN .
_Citation.Conference_title .
_Citation.Conference_site .
_Citation.Conference_state_province .
_Citation.Conference_country .
_Citation.Conference_start_date .
_Citation.Conference_end_date .
_Citation.Conference_abstract_number .
_Citation.Thesis_institution .
_Citation.Thesis_institution_city .
_Citation.Thesis_institution_country .
_Citation.WWW_URL .
_Citation.Page_first 14586
_Citation.Page_last 14596
_Citation.Year 2009
_Citation.Details .
loop_
_Citation_author.Ordinal
_Citation_author.Given_name
_Citation_author.Family_name
_Citation_author.First_initial
_Citation_author.Middle_initials
_Citation_author.Family_title
_Citation_author.Entry_ID
_Citation_author.Citation_ID
1 Q. Hua Q. X. . 16027 1
2 B. Xu B. . . 16027 1
3 K. Huang K. . . 16027 1
4 S. Hu S. Q. . 16027 1
5 S. Nakarawa S. . . 16027 1
6 W. Jia W. . . 16027 1
7 S. Wang S. H. . 16027 1
8 J. Wittaker J. . . 16027 1
9 P. Katsoyannis P. G. . 16027 1
10 M. Weiss M. A. . 16027 1
stop_
save_
#############################################
# Molecular system (assembly) description #
#############################################
save_assembly
_Assembly.Sf_category assembly
_Assembly.Sf_framecode assembly
_Assembly.Entry_ID 16027
_Assembly.ID 1
_Assembly.Name 'INSULIN A CHAIN, INSULIN B CHAIN'
_Assembly.BMRB_code .
_Assembly.Number_of_components 2
_Assembly.Organic_ligands .
_Assembly.Metal_ions .
_Assembly.Non_standard_bonds .
_Assembly.Ambiguous_conformational_states .
_Assembly.Ambiguous_chem_comp_sites .
_Assembly.Molecules_in_chemical_exchange .
_Assembly.Paramagnetic no
_Assembly.Thiol_state .
_Assembly.Molecular_mass .
_Assembly.Enzyme_commission_number .
_Assembly.Details .
_Assembly.DB_query_date .
_Assembly.DB_query_revised_last_date .
loop_
_Entity_assembly.ID
_Entity_assembly.Entity_assembly_name
_Entity_assembly.Entity_ID
_Entity_assembly.Entity_label
_Entity_assembly.Asym_ID
_Entity_assembly.PDB_chain_ID
_Entity_assembly.Experimental_data_reported
_Entity_assembly.Physical_state
_Entity_assembly.Conformational_isomer
_Entity_assembly.Chemical_exchange_state
_Entity_assembly.Magnetic_equivalence_group_code
_Entity_assembly.Role
_Entity_assembly.Details
_Entity_assembly.Entry_ID
_Entity_assembly.Assembly_ID
1 'INSULIN A CHAIN' 1 $INSULIN_A_CHAIN A . yes native no no . . . 16027 1
2 'INSULIN B CHAIN' 2 $INSULIN_B_CHAIN B . yes native no no . . . 16027 1
stop_
save_
####################################
# Biological polymers and ligands #
####################################
save_INSULIN_A_CHAIN
_Entity.Sf_category entity
_Entity.Sf_framecode INSULIN_A_CHAIN
_Entity.Entry_ID 16027
_Entity.ID 1
_Entity.BMRB_code .
_Entity.Name INSULIN_A_CHAIN
_Entity.Type polymer
_Entity.Polymer_common_type .
_Entity.Polymer_type polypeptide(L)
_Entity.Polymer_type_details .
_Entity.Polymer_strand_ID A
_Entity.Polymer_seq_one_letter_code_can .
_Entity.Polymer_seq_one_letter_code
;
GIVEQCCTSICSLYQLENYC
N
;
_Entity.Target_identifier .
_Entity.Polymer_author_defined_seq .
_Entity.Polymer_author_seq_details .
_Entity.Ambiguous_conformational_states no
_Entity.Ambiguous_chem_comp_sites no
_Entity.Nstd_monomer no
_Entity.Nstd_chirality no
_Entity.Nstd_linkage no
_Entity.Nonpolymer_comp_ID .
_Entity.Nonpolymer_comp_label .
_Entity.Number_of_monomers 21
_Entity.Number_of_nonpolymer_components .
_Entity.Paramagnetic no
_Entity.Thiol_state 'all disulfide bound'
_Entity.Src_method nat
_Entity.Parent_entity_ID .
_Entity.Fragment .
_Entity.Mutation .
_Entity.EC_number .
_Entity.Calc_isoelectric_point .
_Entity.Formula_weight 2383.700
_Entity.Formula_weight_exptl .
_Entity.Formula_weight_exptl_meth .
_Entity.Details .
_Entity.DB_query_date .
_Entity.DB_query_revised_last_date 2015-11-25
loop_
_Entity_db_link.Ordinal
_Entity_db_link.Author_supplied
_Entity_db_link.Database_code
_Entity_db_link.Accession_code
_Entity_db_link.Entry_mol_code
_Entity_db_link.Entry_mol_name
_Entity_db_link.Entry_experimental_method
_Entity_db_link.Entry_structure_resolution
_Entity_db_link.Entry_relation_type
_Entity_db_link.Entry_details
_Entity_db_link.Chimera_segment_ID
_Entity_db_link.Seq_query_to_submitted_percent
_Entity_db_link.Seq_subject_length
_Entity_db_link.Seq_identity
_Entity_db_link.Seq_positive
_Entity_db_link.Seq_homology_expectation_val
_Entity_db_link.Seq_align_begin
_Entity_db_link.Seq_align_end
_Entity_db_link.Seq_difference_details
_Entity_db_link.Seq_alignment_details
_Entity_db_link.Entry_ID
_Entity_db_link.Entity_ID
1 no BMRB 1000 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
2 no BMRB 1002 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
3 no BMRB 1004 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
4 no BMRB 1006 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
5 no BMRB 1008 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
6 no BMRB 1010 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
7 no BMRB 1012 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
8 no BMRB 1014 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
9 no BMRB 1016 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
10 no BMRB 1018 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
11 no BMRB 1020 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
12 no BMRB 1022 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
13 no BMRB 1023 . "insulin B chain" . . . . . 95.24 42 100.00 100.00 1.05e-03 . . . . 16027 1
14 no BMRB 11016 . "Chain A" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
15 no BMRB 1344 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
16 no BMRB 15464 . "chain A" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
17 no BMRB 1585 . "insulin A chain" . . . . . 95.24 21 100.00 100.00 1.28e-03 . . . . 16027 1
18 no BMRB 1587 . "insulin A chain" . . . . . 95.24 21 100.00 100.00 1.28e-03 . . . . 16027 1
19 no BMRB 16026 . INSULIN_A_CHAIN . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
20 no BMRB 1632 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
21 no BMRB 16343 . INSULIN_A_CHAIN . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
22 no BMRB 16608 . Proinsulin . . . . . 100.00 86 100.00 100.00 5.99e-05 . . . . 16027 1
23 no BMRB 16663 . "entity, chain 1" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
24 no BMRB 16915 . "entity, chain 1" . . . . . 100.00 22 100.00 100.00 1.61e-04 . . . . 16027 1
25 no BMRB 17107 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
26 no BMRB 1761 . "insulin A chain" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
27 no BMRB 17803 . "InsulinGR 1" . . . . . 100.00 22 100.00 100.00 1.61e-04 . . . . 16027 1
28 no BMRB 18858 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
29 no BMRB 18859 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
30 no BMRB 18921 . chain_A . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
31 no BMRB 18923 . chain_A . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
32 no BMRB 18924 . chain_A . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
33 no BMRB 18925 . chain_A . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
34 no BMRB 19822 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
35 no BMRB 19978 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
36 no BMRB 19979 . entity . . . . . 100.00 51 100.00 100.00 1.21e-04 . . . . 16027 1
37 no BMRB 20052 . Human_Insulin_A-chain_peptide . . . . . 71.43 15 100.00 100.00 4.56e+00 . . . . 16027 1
38 no BMRB 20053 . Insulin_A-chain_variant_peptide . . . . . 71.43 17 100.00 100.00 3.29e+00 . . . . 16027 1
39 no BMRB 25260 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
40 no BMRB 25261 . entity_1 . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
41 no BMRB 4266 . [D-AlaB26]destetra(B27-B30)insulin-B26-amide . . . . . 100.00 47 100.00 100.00 1.07e-04 . . . . 16027 1
42 no PDB 1A7F . "Insulin Mutant B16 Glu, B24 Gly, Des-B30, Nmr, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
43 no PDB 1AI0 . "R6 Human Insulin Hexamer (Non-Symmetric), Nmr, 10 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
44 no PDB 1AIY . "R6 Human Insulin Hexamer (Symmetric), Nmr, 10 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
45 no PDB 1B17 . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 5.00 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
46 no PDB 1B18 . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 5.53 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
47 no PDB 1B19 . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 5.80 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
48 no PDB 1B2A . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.00 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
49 no PDB 1B2B . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.16 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
50 no PDB 1B2C . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.26 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
51 no PDB 1B2D . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.35 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
52 no PDB 1B2E . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.50 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
53 no PDB 1B2F . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 6.98 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
54 no PDB 1B2G . "Ph Affects Glu B13 Switching And Sulfate Binding In Cubic Insulin Crystals (Ph 9.00 Coordinates)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
55 no PDB 1B9E . "Human Insulin Mutant Serb9glu" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
56 no PDB 1BEN . "Insulin Complexed With 4-Hydroxybenzamide" . . . . . 95.24 21 100.00 100.00 1.28e-03 . . . . 16027 1
57 no PDB 1BZV . "[d-Alab26]-Des(B27-B30)-Insulin-B26-Amide A Superpotent Single-Replacement Insulin Analogue, Nmr, Minimized Average Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
58 no PDB 1DEI . "Desheptapeptide (B24-B30) Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
59 no PDB 1EFE . "An Active Mini-Proinsulin, M2pi" . . . . . 100.00 60 100.00 100.00 8.68e-05 . . . . 16027 1
60 no PDB 1EV3 . "Structure Of The Rhombohedral Form Of The M-cresol/insulin R6 Hexamer" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
61 no PDB 1EV6 . "Structure Of The Monoclinic Form Of The M-CresolINSULIN R6 Hexamer" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
62 no PDB 1EVR . "The Structure Of The ResorcinolINSULIN R6 HEXAMER" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
63 no PDB 1FU2 . "First Protein Structure Determined From X-Ray Powder Diffraction Data" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
64 no PDB 1FUB . "First Protein Structure Determined From X-Ray Powder Diffraction Data" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
65 no PDB 1G7A . "1.2 A Structure Of T3r3 Human Insulin At 100 K" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
66 no PDB 1G7B . "1.3 A Structure Of T3r3 Human Insulin At 100 K" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
67 no PDB 1GUJ . "Insulin At Ph 2: Structural Analysis Of The Conditions Promoting Insulin Fibre Formation." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
68 no PDB 1HIQ . "Paradoxical Structure And Function In A Mutant Human Insulin Associated With Diabetes Mellitus" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
69 no PDB 1HIS . "Structure And Dynamics Of Des-Pentapeptide-Insulin In Solution: The Molten-Globule Hypothesis." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
70 no PDB 1HIT . "Receptor Binding Redefined By A Structural Switch In A Mutant Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
71 no PDB 1HLS . "Nmr Structure Of The Human Insulin-His(B16)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
72 no PDB 1HTV . "Crystal Structure Of Destripeptide (B28-B30) Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
73 no PDB 1HUI . "Insulin Mutant (B1, B10, B16, B27)glu, Des-B30, Nmr, 25 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
74 no PDB 1IZA . "Role Of B13 Glu In Insulin Assembly: The Hexamer Structure Of Recombinant Mutant (B13 Glu-> Gln) Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
75 no PDB 1IZB . "Role Of B13 Glu In Insulin Assembly: The Hexamer Structure Of Recombinant Mutant (B13 Glu-> Gln) Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
76 no PDB 1JCO . "Solution Structure Of The Monomeric [thr(B27)->pro,Pro(B28)- >thr] Insulin Mutant (Pt Insulin)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
77 no PDB 1LPH . "Lys(B28)pro(B29)-Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
78 no PDB 1M5A . "Crystal Structure Of 2-Co(2+)-Insulin At 1.2a Resolution" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
79 no PDB 1MHI . "Three-Dimensional Solution Structure Of An Insulin Dimer. A Study Of The B9(Asp) Mutant Of Human Insulin Using Nuclear Magnetic" . . . . . 95.24 21 100.00 100.00 1.28e-03 . . . . 16027 1
80 no PDB 1MHJ . "Solution Structure Of The Superactive Monomeric Des- [phe(B25)] Human Insulin Mutant. Elucidation Of The Structural Basis For T" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
81 no PDB 1MPJ . "X-Ray Crystallographic Studies On Hexameric Insulins In The Presence Of Helix-Stabilizing Agents, Thiocyanate, Methylparaben An" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
82 no PDB 1MSO . "T6 Human Insulin At 1.0 A Resolution" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
83 no PDB 1OS3 . "Dehydrated T6 Human Insulin At 100 K" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
84 no PDB 1OS4 . "Dehydrated T6 Human Insulin At 295 K" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
85 no PDB 1QIY . "Human Insulin Hexamers With Chain B His Mutated To Tyr Complexed With Phenol" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
86 no PDB 1QIZ . "Human Insulin Hexamers With Chain B His Mutated To Tyr Complexed With Resorcinol" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
87 no PDB 1QJ0 . "Human Insulin Hexamers With Chain B His Mutated To Tyr" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
88 no PDB 1SDB . "Porcine Desb1-2 Despentapeptide(B26-B30) Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
89 no PDB 1SF1 . "Nmr Structure Of Human Insulin Under Amyloidogenic Condition, 15 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
90 no PDB 1SJT . "Mini-Proinsulin, Two Chain Insulin Analog Mutant: Des B30, His(B 10)asp, Pro(B 28)asp, Nmr, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
91 no PDB 1SJU . "Mini-Proinsulin, Single Chain Insulin Analog Mutant: Des B30, His(B 10)asp, Pro(B 28)asp And Peptide Bond Between Lys B 29 And " . . . . . 100.00 50 100.00 100.00 1.15e-04 . . . . 16027 1
92 no PDB 1T1K . "Nmr Structure Of Human Insulin Mutant His-B10-Asp, Val-B12- Ala, Pro-B28-Lys, Lys-B29-Pro, 15 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
93 no PDB 1T1P . "Nmr Structure Of Human Insulin Mutant His-B10-Asp, Val-B12- Thr, Pro-B28-Lys, Lys-B29-Pro, 15 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
94 no PDB 1T1Q . "Nmr Structure Of Human Insulin Mutant His-B10-Asp, Val-B12-Aba, Pro- B28-Lys, Lys-B29-Pro, 15 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
95 no PDB 1TRZ . "Crystallographic Evidence For Dual Coordination Around Zinc In The T3r3 Human Insulin Hexamer" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
96 no PDB 1TYL . "The Structure Of A Complex Of Hexameric Insulin And 4'- Hydroxyacetanilide" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
97 no PDB 1TYM . "The Structure Of A Complex Of Hexameric Insulin And 4'- Hydroxyacetanilide" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
98 no PDB 1UZ9 . "Crystallographic And Solution Studies Of N-Lithocholyl Insulin: A New Generation Of Prolonged-Acting Insulins." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
99 no PDB 1W8P . "Structural Properties Of The B25tyr-Nme-B26phe Insulin Mutant." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
100 no PDB 1WAV . "Crystal Structure Of Form B Monoclinic Crystal Of Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
101 no PDB 1XDA . "Structure Of Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
102 no PDB 1XGL . "Human Insulin Disulfide Isomer, Nmr, 10 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
103 no PDB 1ZEG . "Structure Of B28 Asp Insulin In Complex With Phenol" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
104 no PDB 1ZEH . "Structure Of Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
105 no PDB 1ZEI . "Cross-Linked B28 Asp Insulin" . . . . . 100.00 53 100.00 100.00 8.42e-05 . . . . 16027 1
106 no PDB 1ZNI . Insulin . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
107 no PDB 1ZNJ . "Insulin, Monoclinic Crystal Form" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
108 no PDB 2AIY . "R6 Human Insulin Hexamer (Symmetric), Nmr, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
109 no PDB 2C8Q . "Insuline(1sec) And Uv Laser Excited Fluorescence" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
110 no PDB 2C8R . "Insuline(60sec) And Uv Laser Excited Fluorescence" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
111 no PDB 2CEU . "Despentapeptide Insulin In Acetic Acid (Ph 2)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
112 no PDB 2EFA . "Neutron Crystal Structure Of Cubic Insulin At Pd6.6" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
113 no PDB 2G4M . "Insulin Collected At 2.0 A Wavelength" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
114 no PDB 2H67 . "Nmr Structure Of Human Insulin Mutant His-B5-Ala, His-B10- Asp Pro-B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
115 no PDB 2HH4 . "Nmr Structure Of Human Insulin Mutant Gly-B8-D-Ser, His-B10- Asp Pro-B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
116 no PDB 2HHO . "Nmr Structure Of Human Insulin Mutant Gly-B8-Ser, His-B10- Asp Pro-B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
117 no PDB 2HIU . "Nmr Structure Of Human Insulin In 20% Acetic Acid, Zinc- Free, 10 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
118 no PDB 2JMN . "Nmr Structure Of Human Insulin Mutant His-B10-Asp, Pro-B28- Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
119 no PDB 2JV1 . "Nmr Structure Of Human Insulin Monomer In 35% Cd3cn Zinc Free, 50 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
120 no PDB 2K91 . "Enhancing The Activity Of Insulin By Stereospecific Unfolding" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
121 no PDB 2K9R . "Enhancing The Activity Of Insulin By Stereospecific Unfolding" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
122 no PDB 2KJJ . "Dynamics Of Insulin Probed By 1h-Nmr Amide Proton Exchange A Flexibility Of The Receptor-Binding Surface" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
123 no PDB 2KJU . "Nmr Structure Of Human Insulin Mutant Glu-B21-D-Glu, His-B10 B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
124 no PDB 2KQP . "Nmr Structure Of Proinsulin" . . . . . 100.00 86 100.00 100.00 5.99e-05 . . . . 16027 1
125 no PDB 2KQQ . "Nmr Structure Of Human Insulin Mutant Gly-B8-D-Ala, His-B10-Asp, Pro- B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
126 no PDB 2KXK . "Human Insulin Mutant A22gly-B31lys-B32arg" . . . . . 100.00 22 100.00 100.00 1.61e-04 . . . . 16027 1
127 no PDB 2L1Y . "Nmr Structure Of Human Insulin Mutant Gly-B20-D-Ala, Gly-B23-D-Ala Pro-B28-Lys, Lys-B29-Pro, 20 Structures" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
128 no PDB 2LGB . "Modified A22gly-B31arg Human Insulin" . . . . . 100.00 22 100.00 100.00 1.61e-04 . . . . 16027 1
129 no PDB 2M1D . "Biosynthetic Engineered B28k-b29p Human Insulin Monomer Structure In In Water/acetonitrile Solutions." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
130 no PDB 2M1E . "Biosynthetic Engineered B28k-b29p Human Insulin Monomer Structure In In Water Solutions." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
131 no PDB 2M2M . "Structure Of [l-hisb24] Insulin Analogue At Ph 1.9" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
132 no PDB 2M2N . "Structure Of [l-hisb24] Insulin Analogue At Ph 8.0" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
133 no PDB 2M2O . "Structure Of [d-hisb24] Insulin Analogue At Ph 1.9" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
134 no PDB 2M2P . "Structure Of [d-hisb24] Insulin Analogue At Ph 8.0" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
135 no PDB 2MLI . "Nmr Structure Of B25-(alpha, Beta)-dehydro-phenylalanine Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
136 no PDB 2MPG . "Solution Structure Of The [aibb8,lysb28,prob29]-insulin Analogue" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
137 no PDB 2MVC . "Solution Structure Of Human Insulin At Ph 1.9" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
138 no PDB 2MVD . "Solution Structure Of [glnb22]-insulin Mutant At Ph 1.9" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
139 no PDB 2OLY . "Structure Of Human Insulin In Presence Of Urea At Ph 7.0" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
140 no PDB 2OLZ . "Structure Of Human Insulin In Presence Of Thiocyanate At Ph 7.0" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
141 no PDB 2OM0 . "Structure Of Human Insulin In Presence Of Urea At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
142 no PDB 2OM1 . "Structure Of Human Insulin In Presence Of Thiocyanate At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
143 no PDB 2OMG . "Structure Of Human Insulin Cocrystallized With Protamine And Urea" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
144 no PDB 2OMH . "Structure Of Human Insulin Cocrystallized With Arg-12 Peptide In Presence Of Urea" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
145 no PDB 2OMI . "Structure Of Human Insulin Cocrystallized With Protamine" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
146 no PDB 2QIU . "Structure Of Human Arg-Insulin" . . . . . 100.00 22 100.00 100.00 1.33e-04 . . . . 16027 1
147 no PDB 2R34 . "Crystal Structure Of Mn Human Arg-Insulin" . . . . . 100.00 22 100.00 100.00 1.33e-04 . . . . 16027 1
148 no PDB 2R35 . "Crystal Structure Of Rb Human Arg-Insulin" . . . . . 100.00 22 100.00 100.00 1.33e-04 . . . . 16027 1
149 no PDB 2R36 . "Crystal Structure Of Ni Human Arg-Insulin" . . . . . 100.00 22 100.00 100.00 1.33e-04 . . . . 16027 1
150 no PDB 2RN5 . "Humal Insulin Mutant B31lys-B32arg" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
151 no PDB 2TCI . "X-Ray Crystallographic Studies On Hexameric Insulins In The Presence Of Helix-Stabilizing Agents, Thiocyanate, Methylparaben An" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
152 no PDB 2VJZ . "Crystal Structure Form Ultalente Insulin Microcrystals" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
153 no PDB 2VK0 . "Crystal Structure Form Ultalente Insulin Microcrystals" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
154 no PDB 2W44 . "Structure Deltaa1-a4 Insulin" . . . . . 80.95 17 100.00 100.00 1.24e-01 . . . . 16027 1
155 no PDB 2WBY . "Crystal Structure Of Human Insulin-Degrading Enzyme In Complex With Insulin" . . . . . 95.24 20 100.00 100.00 9.42e-04 . . . . 16027 1
156 no PDB 2WC0 . "Crystal Structure Of Human Insulin Degrading Enzyme In Complex With Iodinated Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
157 no PDB 2WRU . "Semi-synthetic Highly Active Analogue Of Human Insulin Nmealab26-dti-nh2" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
158 no PDB 2WRV . "Semi-Synthetic Highly Active Analogue Of Human Insulin Nmehisb26-Dti-Nh2" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
159 no PDB 2WRW . "Semi-Synthetic Highly Active Analogue Of Human Insulin D- Prob26-Dti-Nh2" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
160 no PDB 2WRX . "Semi-Synthetic Analogue Of Human Insulin Nmealab26-Insulin At Ph 3.0" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
161 no PDB 2WS0 . "Semi-Synthetic Analogue Of Human Insulin Nmealab26-Insulin At Ph 7.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
162 no PDB 2WS1 . "Semi-Synthetic Analogue Of Human Insulin Nmetyrb26-Insulin In Monomer Form" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
163 no PDB 2WS4 . "Semi-Synthetic Analogue Of Human Insulin Prob26-Dti In Monomer Form" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
164 no PDB 2WS6 . "Semi-Synthetic Analogue Of Human Insulin Nmetyrb26-Insulin In Hexamer Form" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
165 no PDB 2WS7 . "Semi-Synthetic Analogue Of Human Insulin Prob26-Dti" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
166 no PDB 2ZPP . "Neutron Crystal Structure Of Cubic Insulin At Pd9" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
167 no PDB 3AIY . "R6 Human Insulin Hexamer (Symmetric), Nmr, Refined Average Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
168 no PDB 3BXQ . "The Structure Of A Mutant Insulin Uncouples Receptor Binding From Protein Allostery. An Electrostatic Block To The Tr Transitio" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
169 no PDB 3E7Y . "Structure Of Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
170 no PDB 3E7Z . "Structure Of Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
171 no PDB 3EXX . "Structure Of The T6 Human Insulin Derivative With Nickel At 1.35 A Resolution" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
172 no PDB 3FHP . "A Neutron Crystallographic Analysis Of A Porcine 2zn Insulin At 2.0 A Resolution" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
173 no PDB 3I3Z . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
174 no PDB 3I40 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
175 no PDB 3ILG . "Crystal Structure Of Humnan Insulin Sr+2 Complex" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
176 no PDB 3INC . "Crystal Structure Of Human Insulin With Ni+2 Complex" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
177 no PDB 3INS . "Structure Of Insulin. Results Of Joint Neutron And X-ray Refinement" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
178 no PDB 3IR0 . "Crystal Structure Of Human Insulin Complexed With Cu+2 Metal Ion" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
179 no PDB 3JSD . "Insulin's Biosynthesis And Activity Have Opposing Structural Requirements: A New Factor In Neonatal Diabetes Mellitus" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
180 no PDB 3MTH . "X-Ray Crystallographic Studies On Hexameric Insulins In The Presence Of Helix-Stabilizing Agents, Thiocyanate, Methylparaben An" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
181 no PDB 3P2X . "Insulin Fibrillation Is The Janus Face Of Induced Fit. A Chiaral Clamp Stabilizes The Native State At The Expense Of Activity" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
182 no PDB 3P33 . "Insulin Fibrillation Is The Janus Face Of Induced Fit. A Chiral Clamp Stabilizes The Native State At The Expense Of Activity" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
183 no PDB 3Q6E . "Human Insulin In Complex With Cucurbit[7]uril" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
184 no PDB 3ROV . "Insulin's Biosynthesis And Activity Have Opposing Structural Requirements: A New Factor In Neonatal Diabetes Mellitus" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
185 no PDB 3RTO . "Acoustically Mounted Porcine Insulin Microcrystals Yield An X-Ray Sad Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
186 no PDB 3T2A . "Tmao-Grown Cubic Insulin (Porcine)" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
187 no PDB 3TT8 . "Crystal Structure Analysis Of Cu Human Insulin Derivative" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
188 no PDB 3U4N . "A Novel Covalently Linked Insulin Dimer" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
189 no PDB 3V1G . "Forestalling Insulin Fibrillation By Insertion Of A Chiral Clamp Mechanism-Based Application Of Protein Engineering To Global H" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
190 no PDB 3W11 . "Insulin Receptor Ectodomain Construct Comprising Domains L1-cr In Complex With Human Insulin, Alpha-ct Peptide(704-719) And Fab" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
191 no PDB 3W12 . "Insulin Receptor Ectodomain Construct Comprising Domains L1-cr In Complex With High-affinity Insulin Analogue [d-pro-b26]-dti-n" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
192 no PDB 3W13 . "Insulin Receptor Ectodomain Construct Comprising Domains L1-cr In Complex With High-affinity Insulin Analogue [d-pro-b26]-dti-n" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
193 no PDB 3W7Y . "0.92a Structure Of 2zn Human Insulin At 100k" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
194 no PDB 3W7Z . "1.15a Structure Of Human 2zn Insulin At 293k" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
195 no PDB 3W80 . "Crystal Structure Of Dodecamer Human Insulin With Double C-axis Length Of The Hexamer 2 Zn Insulin Cell" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
196 no PDB 3ZI3 . "Crystal Structure Of The B24his-insulin - Human Analogue" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
197 no PDB 3ZQR . "Nmepheb25 Insulin Analogue Crystal Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
198 no PDB 3ZS2 . "Tyrb25,Nmepheb26,Lysb28,Prob29-Insulin Analogue Crystal Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
199 no PDB 3ZU1 . "Structure Of Lysb29(Nepsilon Omega-Carboxyheptadecanoyl) Des(B30) Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
200 no PDB 4A7E . "X-Ray Crystal Structure Of Porcine Insulin Flash-Cooled At High Pressure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
201 no PDB 4AIY . "R6 Human Insulin Hexamer (Symmetric), Nmr, 'green' Substate, Average Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
202 no PDB 4AJX . "Ligand Controlled Assembly Of Hexamers, Dihexamers, And Linear Multihexamer Structures By An Engineered Acylated Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
203 no PDB 4AJZ . "Ligand Controlled Assembly Of Hexamers, Dihexamers, And Linear Multihexamer Structures By An Engineered Acylated Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
204 no PDB 4AK0 . "Ligand Controlled Assembly Of Hexamers, Dihexamers, And Linear Multihexamer Structures By An Engineered Acylated Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
205 no PDB 4AKJ . "Ligand Controlled Assembly Of Hexamers, Dihexamers, And Linear Multihexamer Structures By An Engineered Acylated Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
206 no PDB 4CXL . "Human Insulin Analogue (d-prob8)-insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
207 no PDB 4CXN . "Crystal Structure Of Human Insulin Analogue (nme-alab8)- Insulin Crystal Form I" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
208 no PDB 4CY7 . "Crystal Structure Of Human Insulin Analogue (nme-alab8)- Insulin Crystal Form Ii" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
209 no PDB 4EWW . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
210 no PDB 4EWX . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
211 no PDB 4EWZ . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
212 no PDB 4EX0 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
213 no PDB 4EX1 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
214 no PDB 4EXX . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
215 no PDB 4EY1 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
216 no PDB 4EY9 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
217 no PDB 4EYD . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
218 no PDB 4EYN . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
219 no PDB 4EYP . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
220 no PDB 4F0N . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
221 no PDB 4F0O . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
222 no PDB 4F1A . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
223 no PDB 4F1B . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
224 no PDB 4F1C . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
225 no PDB 4F1D . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
226 no PDB 4F1F . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
227 no PDB 4F1G . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
228 no PDB 4F4T . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
229 no PDB 4F4V . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
230 no PDB 4F51 . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
231 no PDB 4F8F . "Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
232 no PDB 4FG3 . "Crystal Structure Analysis Of The Human Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
233 no PDB 4FKA . "High Resolution Structure Of The Manganese Derivative Of Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
234 no PDB 4GBC . "Crystal Structure Of Aspart Insulin At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
235 no PDB 4GBI . "Crystal Structure Of Aspart Insulin At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
236 no PDB 4GBK . "Crystal Structure Of Aspart Insulin At Ph 8.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
237 no PDB 4GBL . "Crystal Structure Of Aspart Insulin At Ph 8.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
238 no PDB 4GBN . "Crystal Structure Of Aspart Insulin At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
239 no PDB 4INS . "The Structure Of 2zn Pig Insulin Crystals At 1.5 Angstroms Resolution" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
240 no PDB 4IUZ . "High Resolution Crystal Structure Of Racemic Ester Insulin" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
241 no PDB 4NIB . "Crystal Structure Of Human Insulin Mutant B20 D-ala, B23 D-ala" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
242 no PDB 4OGA . "Insulin In Complex With Site 1 Of The Human Insulin Receptor" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
243 no PDB 4P65 . "Crystal Structure Of An Cyclohexylalanine Substituted Insulin Analog." . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
244 no PDB 4Q5Z . "Crystal Structure Analysis Of Fab-bound Human Insulin Degrading Enzyme (ide) In Complex With Insulin" . . . . . 95.24 20 100.00 100.00 9.42e-04 . . . . 16027 1
245 no PDB 4RXW . "Crystal Structure Of The Cobalt Human Insulin Derivative" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
246 no PDB 4UNE . "Human Insulin B26phe Mutant Crystal Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
247 no PDB 4UNG . "Human Insulin B26asn Mutant Crystal Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
248 no PDB 4UNH . "Human Insulin B26gly Mutant Crystal Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
249 no PDB 4XC4 . "Insulin Co-crystallizes In The Presence Of It Beta-cell Chaperone Sulfatide" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
250 no PDB 5AIY . "R6 Human Insulin Hexamer (Symmetric), Nmr, 'red' Substate, Average Structure" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
251 no PDB 5CNY . "Crystal Structure Of Human Zinc Insulin At Ph 5.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
252 no PDB 5CO2 . "Crystalization Of Human Zinc Insulin At Ph 5.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
253 no PDB 5CO6 . "Crystal Structure Of Human Zinc Insulin At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
254 no PDB 5CO9 . "Crystal Structure Of Human Zinc Insulin At Ph 6.5" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
255 no PDB 6INS . "X-Ray Analysis Of The Single Chain B29-A1 Peptide-Linked Insulin Molecule. A Completely Inactive Analogue" . . . . . 100.00 50 100.00 100.00 1.15e-04 . . . . 16027 1
256 no PDB 7INS . "Structure Of Porcine Insulin Cocrystallized With Clupeine Z" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
257 no PDB 9INS . "Monovalent Cation Binding In Cubic Insulin Crystals" . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
258 no DBJ BAH59081 . "human M-proinsulin [synthetic construct]" . . . . . 100.00 87 100.00 100.00 5.68e-05 . . . . 16027 1
259 no DBJ BAJ17943 . "insulin [synthetic construct]" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
260 no DBJ BAM29044 . "insulin, partial [Suncus murinus]" . . . . . 100.00 77 100.00 100.00 4.41e-05 . . . . 16027 1
261 no EMBL CAA23424 . "unnamed protein product [synthetic construct]" . . . . . 100.00 87 100.00 100.00 5.68e-05 . . . . 16027 1
262 no EMBL CAA23475 . "preproinsulin [Canis sp.]" . . . . . 100.00 110 100.00 100.00 3.91e-05 . . . . 16027 1
263 no EMBL CAA23828 . "preproinsulin [Homo sapiens]" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
264 no EMBL CAA43403 . "Preproinsulin [Pan troglodytes]" . . . . . 100.00 110 100.00 100.00 3.57e-05 . . . . 16027 1
265 no EMBL CAA43405 . "Preproinsulin [Chlorocebus aethiops]" . . . . . 100.00 110 100.00 100.00 3.91e-05 . . . . 16027 1
266 no GB AAA17540 . "insulin, partial [Oryctolagus cuniculus]" . . . . . 100.00 55 100.00 100.00 4.30e-05 . . . . 16027 1
267 no GB AAA19033 . "insulin [Oryctolagus cuniculus]" . . . . . 100.00 110 100.00 100.00 3.87e-05 . . . . 16027 1
268 no GB AAA36849 . "preproinsulin [Macaca fascicularis]" . . . . . 100.00 110 100.00 100.00 3.68e-05 . . . . 16027 1
269 no GB AAA59172 . "insulin [Homo sapiens]" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
270 no GB AAA59173 . "insulin [Homo sapiens]" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
271 no PRF 0601246A . insulin,prepro . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
272 no PRF 1006230A . insulin,pro- . . . . . 100.00 86 100.00 100.00 5.63e-05 . . . . 16027 1
273 no PRF 550086A . insulin . . . . . 100.00 51 100.00 100.00 1.04e-04 . . . . 16027 1
274 no PRF 560164B . insulin . . . . . 100.00 21 100.00 100.00 1.52e-04 . . . . 16027 1
275 no PRF 580107B . insulin . . . . . 100.00 50 100.00 100.00 9.91e-05 . . . . 16027 1
276 no REF NP_000198 . "insulin preproprotein [Homo sapiens]" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
277 no REF NP_001008996 . "insulin preproprotein [Pan troglodytes]" . . . . . 100.00 110 100.00 100.00 3.57e-05 . . . . 16027 1
278 no REF NP_001075804 . "insulin precursor [Oryctolagus cuniculus]" . . . . . 100.00 110 100.00 100.00 3.87e-05 . . . . 16027 1
279 no REF NP_001103242 . "insulin precursor [Sus scrofa]" . . . . . 100.00 108 100.00 100.00 5.54e-05 . . . . 16027 1
280 no REF NP_001123565 . "insulin precursor [Canis lupus familiaris]" . . . . . 100.00 110 100.00 100.00 3.91e-05 . . . . 16027 1
281 no SP P01308 . "RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor" . . . . . 100.00 110 100.00 100.00 5.75e-05 . . . . 16027 1
282 no SP P01311 . "RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor" . . . . . 100.00 110 100.00 100.00 3.87e-05 . . . . 16027 1
283 no SP P01315 . "RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor" . . . . . 100.00 108 100.00 100.00 5.54e-05 . . . . 16027 1
284 no SP P01321 . "RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor" . . . . . 100.00 110 100.00 100.00 3.91e-05 . . . . 16027 1
285 no SP P30406 . "RecName: Full=Insulin; Contains: RecName: Full=Insulin B chain; Contains: RecName: Full=Insulin A chain; Flags: Precursor" . . . . . 100.00 110 100.00 100.00 3.68e-05 . . . . 16027 1
stop_
loop_
_Entity_comp_index.ID
_Entity_comp_index.Auth_seq_ID
_Entity_comp_index.Comp_ID
_Entity_comp_index.Comp_label
_Entity_comp_index.Entry_ID
_Entity_comp_index.Entity_ID
1 . GLY . 16027 1
2 . ILE . 16027 1
3 . VAL . 16027 1
4 . GLU . 16027 1
5 . GLN . 16027 1
6 . CYS . 16027 1
7 . CYS . 16027 1
8 . THR . 16027 1
9 . SER . 16027 1
10 . ILE . 16027 1
11 . CYS . 16027 1
12 . SER . 16027 1
13 . LEU . 16027 1
14 . TYR . 16027 1
15 . GLN . 16027 1
16 . LEU . 16027 1
17 . GLU . 16027 1
18 . ASN . 16027 1
19 . TYR . 16027 1
20 . CYS . 16027 1
21 . ASN . 16027 1
stop_
loop_
_Entity_poly_seq.Hetero
_Entity_poly_seq.Mon_ID
_Entity_poly_seq.Num
_Entity_poly_seq.Comp_index_ID
_Entity_poly_seq.Entry_ID
_Entity_poly_seq.Entity_ID
. GLY 1 1 16027 1
. ILE 2 2 16027 1
. VAL 3 3 16027 1
. GLU 4 4 16027 1
. GLN 5 5 16027 1
. CYS 6 6 16027 1
. CYS 7 7 16027 1
. THR 8 8 16027 1
. SER 9 9 16027 1
. ILE 10 10 16027 1
. CYS 11 11 16027 1
. SER 12 12 16027 1
. LEU 13 13 16027 1
. TYR 14 14 16027 1
. GLN 15 15 16027 1
. LEU 16 16 16027 1
. GLU 17 17 16027 1
. ASN 18 18 16027 1
. TYR 19 19 16027 1
. CYS 20 20 16027 1
. ASN 21 21 16027 1
stop_
save_
save_INSULIN_B_CHAIN
_Entity.Sf_category entity
_Entity.Sf_framecode INSULIN_B_CHAIN
_Entity.Entry_ID 16027
_Entity.ID 2
_Entity.BMRB_code .
_Entity.Name INSULIN_B_CHAIN
_Entity.Type polymer
_Entity.Polymer_common_type .
_Entity.Polymer_type polypeptide(L)
_Entity.Polymer_type_details .
_Entity.Polymer_strand_ID B
_Entity.Polymer_seq_one_letter_code_can .
_Entity.Polymer_seq_one_letter_code
;
FVNQHLCGSDLVEALYLVCG
ERGAFYTKPT
;
_Entity.Target_identifier .
_Entity.Polymer_author_defined_seq .
_Entity.Polymer_author_seq_details .
_Entity.Ambiguous_conformational_states no
_Entity.Ambiguous_chem_comp_sites no
_Entity.Nstd_monomer no
_Entity.Nstd_chirality no
_Entity.Nstd_linkage no
_Entity.Nonpolymer_comp_ID .
_Entity.Nonpolymer_comp_label .
_Entity.Number_of_monomers 30
_Entity.Number_of_nonpolymer_components .
_Entity.Paramagnetic no
_Entity.Thiol_state 'all disulfide bound'
_Entity.Src_method nat
_Entity.Parent_entity_ID .
_Entity.Fragment .
_Entity.Mutation YES
_Entity.EC_number .
_Entity.Calc_isoelectric_point .
_Entity.Formula_weight 3334.823
_Entity.Formula_weight_exptl .
_Entity.Formula_weight_exptl_meth .
_Entity.Details .
_Entity.DB_query_date .
_Entity.DB_query_revised_last_date 2013-12-03
loop_
_Entity_db_link.Author_supplied
_Entity_db_link.Database_code
_Entity_db_link.Accession_code
_Entity_db_link.Entry_mol_code
_Entity_db_link.Entry_mol_name
_Entity_db_link.Entry_experimental_method
_Entity_db_link.Entry_structure_resolution
_Entity_db_link.Entry_relation_type
_Entity_db_link.Entry_details
_Entity_db_link.Chimera_segment_ID
_Entity_db_link.Seq_query_to_submitted_percent
_Entity_db_link.Seq_subject_length
_Entity_db_link.Seq_identity
_Entity_db_link.Seq_positive
_Entity_db_link.Seq_homology_expectation_val
_Entity_db_link.Seq_align_begin
_Entity_db_link.Seq_align_end
_Entity_db_link.Seq_difference_details
_Entity_db_link.Seq_alignment_details
_Entity_db_link.Entry_ID
_Entity_db_link.Entity_ID
no PDB 2K91 . "Enhancing The Activity Of Insulin By Stereospecific Unfolding" . . . . . 100.00 30 100.00 100.00 4.15e-13 . . . . 16027 2
stop_
loop_
_Entity_comp_index.ID
_Entity_comp_index.Auth_seq_ID
_Entity_comp_index.Comp_ID
_Entity_comp_index.Comp_label
_Entity_comp_index.Entry_ID
_Entity_comp_index.Entity_ID
1 . PHE . 16027 2
2 . VAL . 16027 2
3 . ASN . 16027 2
4 . GLN . 16027 2
5 . HIS . 16027 2
6 . LEU . 16027 2
7 . CYS . 16027 2
8 . GLY . 16027 2
9 . SER . 16027 2
10 . ASP . 16027 2
11 . LEU . 16027 2
12 . VAL . 16027 2
13 . GLU . 16027 2
14 . ALA . 16027 2
15 . LEU . 16027 2
16 . TYR . 16027 2
17 . LEU . 16027 2
18 . VAL . 16027 2
19 . CYS . 16027 2
20 . GLY . 16027 2
21 . GLU . 16027 2
22 . ARG . 16027 2
23 . GLY . 16027 2
24 . ALA . 16027 2
25 . PHE . 16027 2
26 . TYR . 16027 2
27 . THR . 16027 2
28 . LYS . 16027 2
29 . PRO . 16027 2
30 . THR . 16027 2
stop_
loop_
_Entity_poly_seq.Hetero
_Entity_poly_seq.Mon_ID
_Entity_poly_seq.Num
_Entity_poly_seq.Comp_index_ID
_Entity_poly_seq.Entry_ID
_Entity_poly_seq.Entity_ID
. PHE 1 1 16027 2
. VAL 2 2 16027 2
. ASN 3 3 16027 2
. GLN 4 4 16027 2
. HIS 5 5 16027 2
. LEU 6 6 16027 2
. CYS 7 7 16027 2
. GLY 8 8 16027 2
. SER 9 9 16027 2
. ASP 10 10 16027 2
. LEU 11 11 16027 2
. VAL 12 12 16027 2
. GLU 13 13 16027 2
. ALA 14 14 16027 2
. LEU 15 15 16027 2
. TYR 16 16 16027 2
. LEU 17 17 16027 2
. VAL 18 18 16027 2
. CYS 19 19 16027 2
. GLY 20 20 16027 2
. GLU 21 21 16027 2
. ARG 22 22 16027 2
. GLY 23 23 16027 2
. ALA 24 24 16027 2
. PHE 25 25 16027 2
. TYR 26 26 16027 2
. THR 27 27 16027 2
. LYS 28 28 16027 2
. PRO 29 29 16027 2
. THR 30 30 16027 2
stop_
save_
####################
# Natural source #
####################
save_natural_source
_Entity_natural_src_list.Sf_category natural_source
_Entity_natural_src_list.Sf_framecode natural_source
_Entity_natural_src_list.Entry_ID 16027
_Entity_natural_src_list.ID 1
loop_
_Entity_natural_src.ID
_Entity_natural_src.Entity_ID
_Entity_natural_src.Entity_label
_Entity_natural_src.Entity_chimera_segment_ID
_Entity_natural_src.NCBI_taxonomy_ID
_Entity_natural_src.Type
_Entity_natural_src.Common
_Entity_natural_src.Organism_name_scientific
_Entity_natural_src.Organism_name_common
_Entity_natural_src.Organism_acronym
_Entity_natural_src.ICTVdb_decimal_code
_Entity_natural_src.Superkingdom
_Entity_natural_src.Kingdom
_Entity_natural_src.Genus
_Entity_natural_src.Species
_Entity_natural_src.Strain
_Entity_natural_src.Variant
_Entity_natural_src.Subvariant
_Entity_natural_src.Organ
_Entity_natural_src.Tissue
_Entity_natural_src.Tissue_fraction
_Entity_natural_src.Cell_line
_Entity_natural_src.Cell_type
_Entity_natural_src.ATCC_number
_Entity_natural_src.Organelle
_Entity_natural_src.Cellular_location
_Entity_natural_src.Fragment
_Entity_natural_src.Fraction
_Entity_natural_src.Secretion
_Entity_natural_src.Plasmid
_Entity_natural_src.Plasmid_details
_Entity_natural_src.Gene_mnemonic
_Entity_natural_src.Dev_stage
_Entity_natural_src.Details
_Entity_natural_src.Citation_ID
_Entity_natural_src.Citation_label
_Entity_natural_src.Entry_ID
_Entity_natural_src.Entity_natural_src_list_ID
1 1 $INSULIN_A_CHAIN . 9606 organism . 'Homo sapiens' Human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . . . . . . . . . . . 16027 1
2 2 $INSULIN_B_CHAIN . 9606 organism . 'Homo sapiens' Human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . . . . . . . . . . . 16027 1
stop_
save_
#########################
# Experimental source #
#########################
save_experimental_source
_Entity_experimental_src_list.Sf_category experimental_source
_Entity_experimental_src_list.Sf_framecode experimental_source
_Entity_experimental_src_list.Entry_ID 16027
_Entity_experimental_src_list.ID 1
loop_
_Entity_experimental_src.ID
_Entity_experimental_src.Entity_ID
_Entity_experimental_src.Entity_label
_Entity_experimental_src.Entity_chimera_segment_ID
_Entity_experimental_src.Production_method
_Entity_experimental_src.Host_org_scientific_name
_Entity_experimental_src.Host_org_name_common
_Entity_experimental_src.Host_org_details
_Entity_experimental_src.Host_org_NCBI_taxonomy_ID
_Entity_experimental_src.Host_org_genus
_Entity_experimental_src.Host_org_species
_Entity_experimental_src.Host_org_strain
_Entity_experimental_src.Host_org_variant
_Entity_experimental_src.Host_org_subvariant
_Entity_experimental_src.Host_org_organ
_Entity_experimental_src.Host_org_tissue
_Entity_experimental_src.Host_org_tissue_fraction
_Entity_experimental_src.Host_org_cell_line
_Entity_experimental_src.Host_org_cell_type
_Entity_experimental_src.Host_org_cellular_location
_Entity_experimental_src.Host_org_organelle
_Entity_experimental_src.Host_org_gene
_Entity_experimental_src.Host_org_culture_collection
_Entity_experimental_src.Host_org_ATCC_number
_Entity_experimental_src.Vector_type
_Entity_experimental_src.PDBview_host_org_vector_name
_Entity_experimental_src.PDBview_plasmid_name
_Entity_experimental_src.Vector_name
_Entity_experimental_src.Vector_details
_Entity_experimental_src.Vendor_name
_Entity_experimental_src.Host_org_dev_stage
_Entity_experimental_src.Details
_Entity_experimental_src.Citation_ID
_Entity_experimental_src.Citation_label
_Entity_experimental_src.Entry_ID
_Entity_experimental_src.Entity_experimental_src_list_ID
1 1 $INSULIN_A_CHAIN . 'recombinant technology' 'Escherichia coli' . . . Escherichia coli . . . . . . . . . . . . . . . . pBR322 . . . . . . 16027 1
2 2 $INSULIN_B_CHAIN . 'recombinant technology' 'Escherichia coli' . . . Escherichia coli . . . . . . . . . . . . . . . . pBR322 . . . . . . 16027 1
stop_
save_
#####################################
# Sample contents and methodology #
#####################################
########################
# Sample description #
########################
save_sample
_Sample.Sf_category sample
_Sample.Sf_framecode sample
_Sample.Entry_ID 16027
_Sample.ID 1
_Sample.Type solution
_Sample.Sub_type .
_Sample.Details '0.5-0.8 mM PROTEIN, 90% H2O/ 10% D2O AND 20% ACETIC ACID'
_Sample.Aggregate_sample_number .
_Sample.Solvent_system '90% H2O/10% D2O'
_Sample.Preparation_date .
_Sample.Preparation_expiration_date .
_Sample.Polycrystallization_protocol .
_Sample.Single_crystal_protocol .
_Sample.Crystal_grow_apparatus .
_Sample.Crystal_grow_atmosphere .
_Sample.Crystal_grow_details .
_Sample.Crystal_grow_method .
_Sample.Crystal_grow_method_cit_ID .
_Sample.Crystal_grow_pH .
_Sample.Crystal_grow_pH_range .
_Sample.Crystal_grow_pressure .
_Sample.Crystal_grow_pressure_esd .
_Sample.Crystal_grow_seeding .
_Sample.Crystal_grow_seeding_cit_ID .
_Sample.Crystal_grow_temp .
_Sample.Crystal_grow_temp_details .
_Sample.Crystal_grow_temp_esd .
_Sample.Crystal_grow_time .
_Sample.Oriented_sample_prep_protocol .
_Sample.Lyophilization_cryo_protectant .
_Sample.Storage_protocol .
loop_
_Sample_component.ID
_Sample_component.Mol_common_name
_Sample_component.Isotopic_labeling
_Sample_component.Assembly_ID
_Sample_component.Assembly_label
_Sample_component.Entity_ID
_Sample_component.Entity_label
_Sample_component.Product_ID
_Sample_component.Type
_Sample_component.Concentration_val
_Sample_component.Concentration_val_min
_Sample_component.Concentration_val_max
_Sample_component.Concentration_val_units
_Sample_component.Concentration_val_err
_Sample_component.Vendor
_Sample_component.Vendor_product_name
_Sample_component.Vendor_product_code
_Sample_component.Entry_ID
_Sample_component.Sample_ID
1 'INSULIN A CHAIN' 'natural abundance' . . 1 $INSULIN_A_CHAIN . . 0.5-0.8 . . mM . . . . 16027 1
2 'INSULIN B CHAIN' 'natural abundance' . . 2 $INSULIN_B_CHAIN . . 0.5-0.8 . . mM . . . . 16027 1
3 H2O 'natural abundance' . . . . . . 90 . . % . . . . 16027 1
4 D2O 'natural abundance' . . . . . . 10 . . % . . . . 16027 1
5 'ACETIC ACID' 'natural abundance' . . . . . . 20 . . % . . . . 16027 1
stop_
save_
#######################
# Sample conditions #
#######################
save_sample_conditions_1
_Sample_condition_list.Sf_category sample_conditions
_Sample_condition_list.Sf_framecode sample_conditions_1
_Sample_condition_list.Entry_ID 16027
_Sample_condition_list.ID 1
_Sample_condition_list.Details '90%H2O/10%D2O, pH7.4'
loop_
_Sample_condition_variable.Type
_Sample_condition_variable.Val
_Sample_condition_variable.Val_err
_Sample_condition_variable.Val_units
_Sample_condition_variable.Entry_ID
_Sample_condition_variable.Sample_condition_list_ID
pH 7.4 . pH 16027 1
temperature 298 . K 16027 1
stop_
save_
############################
# Computer software used #
############################
save_X-PLOR
_Software.Sf_category software
_Software.Sf_framecode X-PLOR
_Software.Entry_ID 16027
_Software.ID 1
_Software.Name X-PLOR
_Software.Version 3.85
_Software.Details .
loop_
_Vendor.Name
_Vendor.Address
_Vendor.Electronic_address
_Vendor.Entry_ID
_Vendor.Software_ID
'BRUNGER, A.T. ET AL.' . . 16027 1
stop_
loop_
_Task.Task
_Task.Entry_ID
_Task.Software_ID
refinement 16027 1
stop_
save_
save_VNMR_6.1B
_Software.Sf_category software
_Software.Sf_framecode VNMR_6.1B
_Software.Entry_ID 16027
_Software.ID 2
_Software.Name VNMR_6.1B
_Software.Version 6.1B
_Software.Details .
loop_
_Vendor.Name
_Vendor.Address
_Vendor.Electronic_address
_Vendor.Entry_ID
_Vendor.Software_ID
Varian . . 16027 2
stop_
loop_
_Task.Task
_Task.Entry_ID
_Task.Software_ID
'structure solution' 16027 2
stop_
save_
#########################
# Experimental detail #
#########################
##################################
# NMR Spectrometer definitions #
##################################
save_spectrometer_1
_NMR_spectrometer.Sf_category NMR_spectrometer
_NMR_spectrometer.Sf_framecode spectrometer_1
_NMR_spectrometer.Entry_ID 16027
_NMR_spectrometer.ID 1
_NMR_spectrometer.Details .
_NMR_spectrometer.Manufacturer VARIAN
_NMR_spectrometer.Model INOVA
_NMR_spectrometer.Serial_number .
_NMR_spectrometer.Field_strength 600
save_
save_600
_NMR_spectrometer_list.Sf_category NMR_spectrometer_list
_NMR_spectrometer_list.Sf_framecode 600
_NMR_spectrometer_list.Entry_ID 16027
_NMR_spectrometer_list.ID 1
loop_
_NMR_spectrometer_view.ID
_NMR_spectrometer_view.Name
_NMR_spectrometer_view.Manufacturer
_NMR_spectrometer_view.Model
_NMR_spectrometer_view.Serial_number
_NMR_spectrometer_view.Field_strength
_NMR_spectrometer_view.Details
_NMR_spectrometer_view.Citation_ID
_NMR_spectrometer_view.Citation_label
_NMR_spectrometer_view.Entry_ID
_NMR_spectrometer_view.NMR_spectrometer_list_ID
1 spectrometer_1 VARIAN INOVA . 600 . . . 16027 1
stop_
save_
#############################
# NMR applied experiments #
#############################
save_experiment_list
_Experiment_list.Sf_category experiment_list
_Experiment_list.Sf_framecode experiment_list
_Experiment_list.Entry_ID 16027
_Experiment_list.ID 1
_Experiment_list.Details 'THIS STRUCTURE WAS DETERMINED USING STANDARD 2D HOMONUCLEAR NMR TECHNIQUES.'
loop_
_Experiment.ID
_Experiment.Name
_Experiment.Raw_data_flag
_Experiment.NMR_spec_expt_ID
_Experiment.NMR_spec_expt_label
_Experiment.MS_expt_ID
_Experiment.MS_expt_label
_Experiment.SAXS_expt_ID
_Experiment.SAXS_expt_label
_Experiment.FRET_expt_ID
_Experiment.FRET_expt_label
_Experiment.EMR_expt_ID
_Experiment.EMR_expt_label
_Experiment.Sample_ID
_Experiment.Sample_label
_Experiment.Sample_state
_Experiment.Sample_volume
_Experiment.Sample_volume_units
_Experiment.Sample_condition_list_ID
_Experiment.Sample_condition_list_label
_Experiment.Sample_spinning_rate
_Experiment.Sample_angle
_Experiment.NMR_tube_type
_Experiment.NMR_spectrometer_ID
_Experiment.NMR_spectrometer_label
_Experiment.NMR_spectrometer_probe_ID
_Experiment.NMR_spectrometer_probe_label
_Experiment.NMR_spectral_processing_ID
_Experiment.NMR_spectral_processing_label
_Experiment.Mass_spectrometer_ID
_Experiment.Mass_spectrometer_label
_Experiment.Xray_instrument_ID
_Experiment.Xray_instrument_label
_Experiment.Fluorescence_instrument_ID
_Experiment.Fluorescence_instrument_label
_Experiment.EMR_instrument_ID
_Experiment.EMR_instrument_label
_Experiment.Chromatographic_system_ID
_Experiment.Chromatographic_system_label
_Experiment.Chromatographic_column_ID
_Experiment.Chromatographic_column_label
_Experiment.Entry_ID
_Experiment.Experiment_list_ID
1 '2D TOCSY' no . . . . . . . . . . 1 $sample isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 16027 1
2 NOESY no . . . . . . . . . . 1 $sample isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 16027 1
3 COSY no . . . . . . . . . . 1 $sample isotropic . . 1 $sample_conditions_1 . . . 1 $spectrometer_1 . . . . . . . . . . . . . . . . 16027 1
stop_
save_
####################
# NMR parameters #
####################
##############################
# Assigned chemical shifts #
##############################
################################
# Chemical shift referencing #
################################
save_chemical_shift_reference_1
_Chem_shift_reference.Sf_category chem_shift_reference
_Chem_shift_reference.Sf_framecode chemical_shift_reference_1
_Chem_shift_reference.Entry_ID 16027
_Chem_shift_reference.ID 1
_Chem_shift_reference.Details .
loop_
_Chem_shift_ref.Atom_type
_Chem_shift_ref.Atom_isotope_number
_Chem_shift_ref.Mol_common_name
_Chem_shift_ref.Atom_group
_Chem_shift_ref.Concentration_val
_Chem_shift_ref.Concentration_units
_Chem_shift_ref.Solvent
_Chem_shift_ref.Rank
_Chem_shift_ref.Chem_shift_units
_Chem_shift_ref.Chem_shift_val
_Chem_shift_ref.Ref_method
_Chem_shift_ref.Ref_type
_Chem_shift_ref.Indirect_shift_ratio
_Chem_shift_ref.External_ref_loc
_Chem_shift_ref.External_ref_sample_geometry
_Chem_shift_ref.External_ref_axis
_Chem_shift_ref.Indirect_shift_ratio_cit_ID
_Chem_shift_ref.Indirect_shift_ratio_cit_label
_Chem_shift_ref.Ref_correction_type
_Chem_shift_ref.Correction_val
_Chem_shift_ref.Correction_val_cit_ID
_Chem_shift_ref.Correction_val_cit_label
_Chem_shift_ref.Entry_ID
_Chem_shift_ref.Chem_shift_reference_ID
H 1 DSS 'methyl protons' . . . . ppm 0.00 internal direct 1.000000000 . . . . . . . . . 16027 1
stop_
save_
###################################
# Assigned chemical shift lists #
###################################
###################################################################
# Chemical Shift Ambiguity Index Value Definitions #
# #
# The values other than 1 are used for those atoms with different #
# chemical shifts that cannot be assigned to stereospecific atoms #
# or to specific residues or chains. #
# #
# Index Value Definition #
# #
# 1 Unique (including isolated methyl protons, #
# geminal atoms, and geminal methyl #
# groups with identical chemical shifts) #
# (e.g. ILE HD11, HD12, HD13 protons) #
# 2 Ambiguity of geminal atoms or geminal methyl #
# proton groups (e.g. ASP HB2 and HB3 #
# protons, LEU CD1 and CD2 carbons, or #
# LEU HD11, HD12, HD13 and HD21, HD22, #
# HD23 methyl protons) #
# 3 Aromatic atoms on opposite sides of #
# symmetrical rings (e.g. TYR HE1 and HE2 #
# protons) #
# 4 Intraresidue ambiguities (e.g. LYS HG and #
# HD protons or TRP HZ2 and HZ3 protons) #
# 5 Interresidue ambiguities (LYS 12 vs. LYS 27) #
# 6 Intermolecular ambiguities (e.g. ASP 31 CA #
# in monomer 1 and ASP 31 CA in monomer 2 #
# of an asymmetrical homodimer, duplex #
# DNA assignments, or other assignments #
# that may apply to atoms in one or more #
# molecule in the molecular assembly) #
# 9 Ambiguous, specific ambiguity not defined #
# #
###################################################################
save_assigned_chem_shift_list_1
_Assigned_chem_shift_list.Sf_category assigned_chemical_shifts
_Assigned_chem_shift_list.Sf_framecode assigned_chem_shift_list_1
_Assigned_chem_shift_list.Entry_ID 16027
_Assigned_chem_shift_list.ID 1
_Assigned_chem_shift_list.Sample_condition_list_ID 1
_Assigned_chem_shift_list.Sample_condition_list_label $sample_conditions_1
_Assigned_chem_shift_list.Chem_shift_reference_ID 1
_Assigned_chem_shift_list.Chem_shift_reference_label $chemical_shift_reference_1
_Assigned_chem_shift_list.Chem_shift_1H_err 0.01
_Assigned_chem_shift_list.Chem_shift_13C_err .
_Assigned_chem_shift_list.Chem_shift_15N_err .
_Assigned_chem_shift_list.Chem_shift_31P_err .
_Assigned_chem_shift_list.Chem_shift_2H_err .
_Assigned_chem_shift_list.Chem_shift_19F_err .
_Assigned_chem_shift_list.Error_derivation_method .
_Assigned_chem_shift_list.Details .
_Assigned_chem_shift_list.Text_data_format .
_Assigned_chem_shift_list.Text_data .
loop_
_Chem_shift_experiment.Experiment_ID
_Chem_shift_experiment.Experiment_name
_Chem_shift_experiment.Sample_ID
_Chem_shift_experiment.Sample_label
_Chem_shift_experiment.Sample_state
_Chem_shift_experiment.Entry_ID
_Chem_shift_experiment.Assigned_chem_shift_list_ID
1 '2D TOCSY' . . . 16027 1
2 NOESY . . . 16027 1
3 COSY . . . 16027 1
stop_
loop_
_Atom_chem_shift.ID
_Atom_chem_shift.Assembly_atom_ID
_Atom_chem_shift.Entity_assembly_ID
_Atom_chem_shift.Entity_ID
_Atom_chem_shift.Comp_index_ID
_Atom_chem_shift.Seq_ID
_Atom_chem_shift.Comp_ID
_Atom_chem_shift.Atom_ID
_Atom_chem_shift.Atom_type
_Atom_chem_shift.Atom_isotope_number
_Atom_chem_shift.Val
_Atom_chem_shift.Val_err
_Atom_chem_shift.Assign_fig_of_merit
_Atom_chem_shift.Ambiguity_code
_Atom_chem_shift.Occupancy
_Atom_chem_shift.Resonance_ID
_Atom_chem_shift.Auth_entity_assembly_ID
_Atom_chem_shift.Auth_asym_ID
_Atom_chem_shift.Auth_seq_ID
_Atom_chem_shift.Auth_comp_ID
_Atom_chem_shift.Auth_atom_ID
_Atom_chem_shift.Details
_Atom_chem_shift.Entry_ID
_Atom_chem_shift.Assigned_chem_shift_list_ID
1 . 1 1 2 2 ILE HA H 1 3.82 0.01 . 1 . . . . 2 ILE HA . 16027 1
2 . 1 1 2 2 ILE HB H 1 1.22 0.01 . 1 . . . . 2 ILE HB . 16027 1
3 . 1 1 2 2 ILE HD11 H 1 0.59 0.01 . 1 . . . . 2 ILE HD1 . 16027 1
4 . 1 1 2 2 ILE HD12 H 1 0.59 0.01 . 1 . . . . 2 ILE HD1 . 16027 1
5 . 1 1 2 2 ILE HD13 H 1 0.59 0.01 . 1 . . . . 2 ILE HD1 . 16027 1
6 . 1 1 2 2 ILE HG12 H 1 1.11 0.01 . 2 . . . . 2 ILE HG12 . 16027 1
7 . 1 1 2 2 ILE HG13 H 1 0.90 0.01 . 2 . . . . 2 ILE HG13 . 16027 1
8 . 1 1 2 2 ILE HG21 H 1 0.68 0.01 . 1 . . . . 2 ILE HG2 . 16027 1
9 . 1 1 2 2 ILE HG22 H 1 0.68 0.01 . 1 . . . . 2 ILE HG2 . 16027 1
10 . 1 1 2 2 ILE HG23 H 1 0.68 0.01 . 1 . . . . 2 ILE HG2 . 16027 1
11 . 1 1 3 3 VAL H H 1 8.12 0.01 . 1 . . . . 3 VAL H . 16027 1
12 . 1 1 3 3 VAL HA H 1 3.60 0.01 . 1 . . . . 3 VAL HA . 16027 1
13 . 1 1 3 3 VAL HB H 1 1.95 0.01 . 1 . . . . 3 VAL HB . 16027 1
14 . 1 1 3 3 VAL HG11 H 1 0.94 0.01 . 1 . . . . 3 VAL HG1 . 16027 1
15 . 1 1 3 3 VAL HG12 H 1 0.94 0.01 . 1 . . . . 3 VAL HG1 . 16027 1
16 . 1 1 3 3 VAL HG13 H 1 0.94 0.01 . 1 . . . . 3 VAL HG1 . 16027 1
17 . 1 1 3 3 VAL HG21 H 1 0.88 0.01 . 1 . . . . 3 VAL HG2 . 16027 1
18 . 1 1 3 3 VAL HG22 H 1 0.88 0.01 . 1 . . . . 3 VAL HG2 . 16027 1
19 . 1 1 3 3 VAL HG23 H 1 0.88 0.01 . 1 . . . . 3 VAL HG2 . 16027 1
20 . 1 1 4 4 GLU HA H 1 4.09 0.01 . 1 . . . . 4 GLU HA . 16027 1
21 . 1 1 4 4 GLU HB2 H 1 2.19 0.01 . 1 . . . . 4 GLU HB2 . 16027 1
22 . 1 1 4 4 GLU HB3 H 1 2.19 0.01 . 1 . . . . 4 GLU HB3 . 16027 1
23 . 1 1 4 4 GLU HG2 H 1 2.49 0.01 . 2 . . . . 4 GLU HG2 . 16027 1
24 . 1 1 4 4 GLU HG3 H 1 2.38 0.01 . 2 . . . . 4 GLU HG3 . 16027 1
25 . 1 1 5 5 GLN HA H 1 4.12 0.01 . 1 . . . . 5 GLN HA . 16027 1
26 . 1 1 5 5 GLN HB2 H 1 2.12 0.01 . 1 . . . . 5 GLN HB2 . 16027 1
27 . 1 1 5 5 GLN HB3 H 1 2.12 0.01 . 1 . . . . 5 GLN HB3 . 16027 1
28 . 1 1 5 5 GLN HE21 H 1 6.94 0.01 . 2 . . . . 5 GLN HE21 . 16027 1
29 . 1 1 5 5 GLN HE22 H 1 7.48 0.01 . 2 . . . . 5 GLN HE22 . 16027 1
30 . 1 1 5 5 GLN HG2 H 1 2.46 0.01 . 2 . . . . 5 GLN HG2 . 16027 1
31 . 1 1 5 5 GLN HG3 H 1 2.25 0.01 . 2 . . . . 5 GLN HG3 . 16027 1
32 . 1 1 6 6 CYS HA H 1 5.02 0.01 . 1 . . . . 6 CYS HA . 16027 1
33 . 1 1 6 6 CYS HB2 H 1 3.37 0.01 . 2 . . . . 6 CYS HB2 . 16027 1
34 . 1 1 6 6 CYS HB3 H 1 2.89 0.01 . 2 . . . . 6 CYS HB3 . 16027 1
35 . 1 1 7 7 CYS HA H 1 4.89 0.01 . 1 . . . . 7 CYS HA . 16027 1
36 . 1 1 7 7 CYS HB2 H 1 3.76 0.01 . 2 . . . . 7 CYS HB2 . 16027 1
37 . 1 1 7 7 CYS HB3 H 1 3.32 0.01 . 2 . . . . 7 CYS HB3 . 16027 1
38 . 1 1 8 8 THR H H 1 8.08 0.01 . 1 . . . . 8 THR H . 16027 1
39 . 1 1 8 8 THR HA H 1 4.10 0.01 . 1 . . . . 8 THR HA . 16027 1
40 . 1 1 8 8 THR HB H 1 4.41 0.01 . 1 . . . . 8 THR HB . 16027 1
41 . 1 1 8 8 THR HG21 H 1 1.25 0.01 . 1 . . . . 8 THR HG2 . 16027 1
42 . 1 1 8 8 THR HG22 H 1 1.25 0.01 . 1 . . . . 8 THR HG2 . 16027 1
43 . 1 1 8 8 THR HG23 H 1 1.25 0.01 . 1 . . . . 8 THR HG2 . 16027 1
44 . 1 1 9 9 SER HA H 1 4.70 0.01 . 1 . . . . 9 SER HA . 16027 1
45 . 1 1 9 9 SER HB2 H 1 3.99 0.01 . 2 . . . . 9 SER HB2 . 16027 1
46 . 1 1 9 9 SER HB3 H 1 3.84 0.01 . 2 . . . . 9 SER HB3 . 16027 1
47 . 1 1 10 10 ILE H H 1 7.81 0.01 . 1 . . . . 10 ILE H . 16027 1
48 . 1 1 10 10 ILE HA H 1 4.29 0.01 . 1 . . . . 10 ILE HA . 16027 1
49 . 1 1 10 10 ILE HB H 1 1.58 0.01 . 1 . . . . 10 ILE HB . 16027 1
50 . 1 1 10 10 ILE HD11 H 1 0.51 0.01 . 1 . . . . 10 ILE HD1 . 16027 1
51 . 1 1 10 10 ILE HD12 H 1 0.51 0.01 . 1 . . . . 10 ILE HD1 . 16027 1
52 . 1 1 10 10 ILE HD13 H 1 0.51 0.01 . 1 . . . . 10 ILE HD1 . 16027 1
53 . 1 1 10 10 ILE HG12 H 1 1.10 0.01 . 2 . . . . 10 ILE HG12 . 16027 1
54 . 1 1 10 10 ILE HG13 H 1 0.47 0.01 . 2 . . . . 10 ILE HG13 . 16027 1
55 . 1 1 10 10 ILE HG21 H 1 0.68 0.01 . 1 . . . . 10 ILE HG2 . 16027 1
56 . 1 1 10 10 ILE HG22 H 1 0.68 0.01 . 1 . . . . 10 ILE HG2 . 16027 1
57 . 1 1 10 10 ILE HG23 H 1 0.68 0.01 . 1 . . . . 10 ILE HG2 . 16027 1
58 . 1 1 11 11 CYS HA H 1 4.93 0.01 . 1 . . . . 11 CYS HA . 16027 1
59 . 1 1 11 11 CYS HB2 H 1 3.19 0.01 . 1 . . . . 11 CYS HB2 . 16027 1
60 . 1 1 11 11 CYS HB3 H 1 3.19 0.01 . 1 . . . . 11 CYS HB3 . 16027 1
61 . 1 1 12 12 SER H H 1 8.24 0.01 . 1 . . . . 12 SER H . 16027 1
62 . 1 1 12 12 SER HA H 1 4.62 0.01 . 1 . . . . 12 SER HA . 16027 1
63 . 1 1 12 12 SER HB2 H 1 4.13 0.01 . 2 . . . . 12 SER HB2 . 16027 1
64 . 1 1 12 12 SER HB3 H 1 3.99 0.01 . 2 . . . . 12 SER HB3 . 16027 1
65 . 1 1 13 13 LEU HA H 1 3.91 0.01 . 1 . . . . 13 LEU HA . 16027 1
66 . 1 1 13 13 LEU HB2 H 1 1.55 0.01 . 2 . . . . 13 LEU HB2 . 16027 1
67 . 1 1 13 13 LEU HB3 H 1 1.47 0.01 . 2 . . . . 13 LEU HB3 . 16027 1
68 . 1 1 13 13 LEU HD11 H 1 0.85 0.01 . 2 . . . . 13 LEU HD1 . 16027 1
69 . 1 1 13 13 LEU HD12 H 1 0.85 0.01 . 2 . . . . 13 LEU HD1 . 16027 1
70 . 1 1 13 13 LEU HD13 H 1 0.85 0.01 . 2 . . . . 13 LEU HD1 . 16027 1
71 . 1 1 13 13 LEU HD21 H 1 0.80 0.01 . 2 . . . . 13 LEU HD2 . 16027 1
72 . 1 1 13 13 LEU HD22 H 1 0.80 0.01 . 2 . . . . 13 LEU HD2 . 16027 1
73 . 1 1 13 13 LEU HD23 H 1 0.80 0.01 . 2 . . . . 13 LEU HD2 . 16027 1
74 . 1 1 13 13 LEU HG H 1 1.55 0.01 . 1 . . . . 13 LEU HG . 16027 1
75 . 1 1 14 14 TYR H H 1 7.63 0.01 . 1 . . . . 14 TYR H . 16027 1
76 . 1 1 14 14 TYR HA H 1 4.33 0.01 . 1 . . . . 14 TYR HA . 16027 1
77 . 1 1 14 14 TYR HB2 H 1 3.00 0.01 . 1 . . . . 14 TYR HB2 . 16027 1
78 . 1 1 14 14 TYR HB3 H 1 3.00 0.01 . 1 . . . . 14 TYR HB3 . 16027 1
79 . 1 1 14 14 TYR HD1 H 1 7.12 0.01 . 1 . . . . 14 TYR HD1 . 16027 1
80 . 1 1 14 14 TYR HD2 H 1 7.12 0.01 . 1 . . . . 14 TYR HD2 . 16027 1
81 . 1 1 14 14 TYR HE1 H 1 6.85 0.01 . 1 . . . . 14 TYR HE1 . 16027 1
82 . 1 1 14 14 TYR HE2 H 1 6.85 0.01 . 1 . . . . 14 TYR HE2 . 16027 1
83 . 1 1 15 15 GLN H H 1 7.51 0.01 . 1 . . . . 15 GLN H . 16027 1
84 . 1 1 15 15 GLN HA H 1 3.99 0.01 . 1 . . . . 15 GLN HA . 16027 1
85 . 1 1 15 15 GLN HB2 H 1 2.21 0.01 . 2 . . . . 15 GLN HB2 . 16027 1
86 . 1 1 15 15 GLN HB3 H 1 2.05 0.01 . 2 . . . . 15 GLN HB3 . 16027 1
87 . 1 1 15 15 GLN HG2 H 1 2.39 0.01 . 2 . . . . 15 GLN HG2 . 16027 1
88 . 1 1 15 15 GLN HG3 H 1 2.32 0.01 . 2 . . . . 15 GLN HG3 . 16027 1
89 . 1 1 16 16 LEU H H 1 7.89 0.01 . 1 . . . . 16 LEU H . 16027 1
90 . 1 1 16 16 LEU HA H 1 4.16 0.01 . 1 . . . . 16 LEU HA . 16027 1
91 . 1 1 16 16 LEU HB2 H 1 1.98 0.01 . 2 . . . . 16 LEU HB2 . 16027 1
92 . 1 1 16 16 LEU HB3 H 1 1.52 0.01 . 2 . . . . 16 LEU HB3 . 16027 1
93 . 1 1 16 16 LEU HD11 H 1 0.81 0.01 . 1 . . . . 16 LEU HD1 . 16027 1
94 . 1 1 16 16 LEU HD12 H 1 0.81 0.01 . 1 . . . . 16 LEU HD1 . 16027 1
95 . 1 1 16 16 LEU HD13 H 1 0.81 0.01 . 1 . . . . 16 LEU HD1 . 16027 1
96 . 1 1 16 16 LEU HD21 H 1 0.81 0.01 . 1 . . . . 16 LEU HD2 . 16027 1
97 . 1 1 16 16 LEU HD22 H 1 0.81 0.01 . 1 . . . . 16 LEU HD2 . 16027 1
98 . 1 1 16 16 LEU HD23 H 1 0.81 0.01 . 1 . . . . 16 LEU HD2 . 16027 1
99 . 1 1 16 16 LEU HG H 1 1.79 0.01 . 1 . . . . 16 LEU HG . 16027 1
100 . 1 1 17 17 GLU HA H 1 4.16 0.01 . 1 . . . . 17 GLU HA . 16027 1
101 . 1 1 17 17 GLU HB2 H 1 2.12 0.01 . 2 . . . . 17 GLU HB2 . 16027 1
102 . 1 1 17 17 GLU HB3 H 1 2.20 0.01 . 2 . . . . 17 GLU HB3 . 16027 1
103 . 1 1 17 17 GLU HG2 H 1 2.31 0.01 . 1 . . . . 17 GLU HG2 . 16027 1
104 . 1 1 17 17 GLU HG3 H 1 2.29 0.01 . 1 . . . . 17 GLU HG3 . 16027 1
105 . 1 1 18 18 ASN H H 1 7.38 0.01 . 1 . . . . 18 ASN H . 16027 1
106 . 1 1 18 18 ASN HA H 1 4.47 0.01 . 1 . . . . 18 ASN HA . 16027 1
107 . 1 1 18 18 ASN HB2 H 1 2.57 0.01 . 2 . . . . 18 ASN HB2 . 16027 1
108 . 1 1 18 18 ASN HB3 H 1 2.51 0.01 . 2 . . . . 18 ASN HB3 . 16027 1
109 . 1 1 18 18 ASN HD21 H 1 6.56 0.01 . 2 . . . . 18 ASN HD21 . 16027 1
110 . 1 1 18 18 ASN HD22 H 1 7.16 0.01 . 2 . . . . 18 ASN HD22 . 16027 1
111 . 1 1 19 19 TYR H H 1 7.95 0.01 . 1 . . . . 19 TYR H . 16027 1
112 . 1 1 19 19 TYR HA H 1 4.48 0.01 . 1 . . . . 19 TYR HA . 16027 1
113 . 1 1 19 19 TYR HB2 H 1 3.32 0.01 . 2 . . . . 19 TYR HB2 . 16027 1
114 . 1 1 19 19 TYR HB3 H 1 2.95 0.01 . 2 . . . . 19 TYR HB3 . 16027 1
115 . 1 1 19 19 TYR HD1 H 1 7.26 0.01 . 1 . . . . 19 TYR HD1 . 16027 1
116 . 1 1 19 19 TYR HD2 H 1 7.26 0.01 . 1 . . . . 19 TYR HD2 . 16027 1
117 . 1 1 19 19 TYR HE1 H 1 6.76 0.01 . 1 . . . . 19 TYR HE1 . 16027 1
118 . 1 1 19 19 TYR HE2 H 1 6.76 0.01 . 1 . . . . 19 TYR HE2 . 16027 1
119 . 1 1 20 20 CYS H H 1 7.44 0.01 . 1 . . . . 20 CYS H . 16027 1
120 . 1 1 20 20 CYS HA H 1 4.88 0.01 . 1 . . . . 20 CYS HA . 16027 1
121 . 1 1 20 20 CYS HB2 H 1 3.29 0.01 . 2 . . . . 20 CYS HB2 . 16027 1
122 . 1 1 20 20 CYS HB3 H 1 2.87 0.01 . 2 . . . . 20 CYS HB3 . 16027 1
123 . 1 1 21 21 ASN H H 1 8.04 0.01 . 1 . . . . 21 ASN H . 16027 1
124 . 1 1 21 21 ASN HA H 1 4.47 0.01 . 1 . . . . 21 ASN HA . 16027 1
125 . 1 1 21 21 ASN HB2 H 1 2.77 0.01 . 2 . . . . 21 ASN HB2 . 16027 1
126 . 1 1 21 21 ASN HB3 H 1 2.62 0.01 . 2 . . . . 21 ASN HB3 . 16027 1
127 . 1 1 21 21 ASN HD21 H 1 6.62 0.01 . 1 . . . . 21 ASN HD21 . 16027 1
128 . 1 1 21 21 ASN HD22 H 1 7.45 0.01 . 1 . . . . 21 ASN HD22 . 16027 1
129 . 2 2 1 1 PHE HA H 1 4.00 0.01 . 1 . . . . 1 PHE HA . 16027 1
130 . 2 2 1 1 PHE HB2 H 1 3.08 0.01 . 1 . . . . 1 PHE HB2 . 16027 1
131 . 2 2 1 1 PHE HB3 H 1 3.08 0.01 . 1 . . . . 1 PHE HB3 . 16027 1
132 . 2 2 1 1 PHE HD1 H 1 7.20 0.01 . 1 . . . . 1 PHE HD1 . 16027 1
133 . 2 2 1 1 PHE HD2 H 1 7.20 0.01 . 1 . . . . 1 PHE HD2 . 16027 1
134 . 2 2 1 1 PHE HE1 H 1 7.32 0.01 . 1 . . . . 1 PHE HE1 . 16027 1
135 . 2 2 1 1 PHE HE2 H 1 7.32 0.01 . 1 . . . . 1 PHE HE2 . 16027 1
136 . 2 2 2 2 VAL HA H 1 4.03 0.01 . 1 . . . . 2 VAL HA . 16027 1
137 . 2 2 2 2 VAL HB H 1 1.96 0.01 . 1 . . . . 2 VAL HB . 16027 1
138 . 2 2 2 2 VAL HG11 H 1 0.82 0.01 . 1 . . . . 2 VAL HG1 . 16027 1
139 . 2 2 2 2 VAL HG12 H 1 0.82 0.01 . 1 . . . . 2 VAL HG1 . 16027 1
140 . 2 2 2 2 VAL HG13 H 1 0.82 0.01 . 1 . . . . 2 VAL HG1 . 16027 1
141 . 2 2 2 2 VAL HG21 H 1 0.82 0.01 . 1 . . . . 2 VAL HG2 . 16027 1
142 . 2 2 2 2 VAL HG22 H 1 0.82 0.01 . 1 . . . . 2 VAL HG2 . 16027 1
143 . 2 2 2 2 VAL HG23 H 1 0.82 0.01 . 1 . . . . 2 VAL HG2 . 16027 1
144 . 2 2 3 3 ASN HA H 1 4.59 0.01 . 1 . . . . 3 ASN HA . 16027 1
145 . 2 2 3 3 ASN HB2 H 1 2.81 0.01 . 2 . . . . 3 ASN HB2 . 16027 1
146 . 2 2 3 3 ASN HB3 H 1 2.76 0.01 . 2 . . . . 3 ASN HB3 . 16027 1
147 . 2 2 4 4 GLN HA H 1 4.47 0.01 . 1 . . . . 4 GLN HA . 16027 1
148 . 2 2 4 4 GLN HB2 H 1 2.07 0.01 . 2 . . . . 4 GLN HB2 . 16027 1
149 . 2 2 4 4 GLN HB3 H 1 1.98 0.01 . 2 . . . . 4 GLN HB3 . 16027 1
150 . 2 2 4 4 GLN HE21 H 1 6.82 0.01 . 2 . . . . 4 GLN HE21 . 16027 1
151 . 2 2 4 4 GLN HE22 H 1 7.34 0.01 . 2 . . . . 4 GLN HE22 . 16027 1
152 . 2 2 4 4 GLN HG2 H 1 2.19 0.01 . 1 . . . . 4 GLN HG2 . 16027 1
153 . 2 2 4 4 GLN HG3 H 1 2.19 0.01 . 1 . . . . 4 GLN HG3 . 16027 1
154 . 2 2 5 5 HIS HA H 1 4.41 0.01 . 1 . . . . 5 HIS HA . 16027 1
155 . 2 2 5 5 HIS HB2 H 1 3.43 0.01 . 2 . . . . 5 HIS HB2 . 16027 1
156 . 2 2 5 5 HIS HB3 H 1 3.11 0.01 . 2 . . . . 5 HIS HB3 . 16027 1
157 . 2 2 5 5 HIS HD2 H 1 7.00 0.01 . 1 . . . . 5 HIS HD2 . 16027 1
158 . 2 2 6 6 LEU HA H 1 4.58 0.01 . 1 . . . . 6 LEU HA . 16027 1
159 . 2 2 6 6 LEU HB2 H 1 1.76 0.01 . 2 . . . . 6 LEU HB2 . 16027 1
160 . 2 2 6 6 LEU HB3 H 1 0.87 0.01 . 2 . . . . 6 LEU HB3 . 16027 1
161 . 2 2 6 6 LEU HD11 H 1 0.87 0.01 . 2 . . . . 6 LEU HD1 . 16027 1
162 . 2 2 6 6 LEU HD12 H 1 0.87 0.01 . 2 . . . . 6 LEU HD1 . 16027 1
163 . 2 2 6 6 LEU HD13 H 1 0.87 0.01 . 2 . . . . 6 LEU HD1 . 16027 1
164 . 2 2 6 6 LEU HD21 H 1 0.78 0.01 . 2 . . . . 6 LEU HD2 . 16027 1
165 . 2 2 6 6 LEU HD22 H 1 0.78 0.01 . 2 . . . . 6 LEU HD2 . 16027 1
166 . 2 2 6 6 LEU HD23 H 1 0.78 0.01 . 2 . . . . 6 LEU HD2 . 16027 1
167 . 2 2 6 6 LEU HG H 1 1.61 0.01 . 1 . . . . 6 LEU HG . 16027 1
168 . 2 2 7 7 CYS H H 1 8.74 0.01 . 1 . . . . 7 CYS H . 16027 1
169 . 2 2 7 7 CYS HA H 1 4.94 0.01 . 1 . . . . 7 CYS HA . 16027 1
170 . 2 2 7 7 CYS HB2 H 1 3.22 0.01 . 2 . . . . 7 CYS HB2 . 16027 1
171 . 2 2 7 7 CYS HB3 H 1 2.99 0.01 . 2 . . . . 7 CYS HB3 . 16027 1
172 . 2 2 8 8 GLY HA2 H 1 4.01 0.01 . 2 . . . . 8 GLY HA1 . 16027 1
173 . 2 2 8 8 GLY HA3 H 1 3.85 0.01 . 2 . . . . 8 GLY HA2 . 16027 1
174 . 2 2 9 9 SER HA H 1 4.14 0.01 . 1 . . . . 9 SER HA . 16027 1
175 . 2 2 9 9 SER HB2 H 1 4.02 0.01 . 2 . . . . 9 SER HB2 . 16027 1
176 . 2 2 9 9 SER HB3 H 1 3.92 0.01 . 2 . . . . 9 SER HB3 . 16027 1
177 . 2 2 10 10 ASP H H 1 8.04 0.01 . 1 . . . . 10 ASP H . 16027 1
178 . 2 2 10 10 ASP HA H 1 4.45 0.01 . 1 . . . . 10 ASP HA . 16027 1
179 . 2 2 10 10 ASP HB2 H 1 2.98 0.01 . 2 . . . . 10 ASP HB2 . 16027 1
180 . 2 2 10 10 ASP HB3 H 1 2.68 0.01 . 2 . . . . 10 ASP HB3 . 16027 1
181 . 2 2 11 11 LEU H H 1 7.05 0.01 . 1 . . . . 11 LEU H . 16027 1
182 . 2 2 11 11 LEU HA H 1 4.00 0.01 . 1 . . . . 11 LEU HA . 16027 1
183 . 2 2 11 11 LEU HB2 H 1 1.85 0.01 . 2 . . . . 11 LEU HB2 . 16027 1
184 . 2 2 11 11 LEU HB3 H 1 1.27 0.01 . 2 . . . . 11 LEU HB3 . 16027 1
185 . 2 2 11 11 LEU HD11 H 1 0.78 0.01 . 1 . . . . 11 LEU HD1 . 16027 1
186 . 2 2 11 11 LEU HD12 H 1 0.78 0.01 . 1 . . . . 11 LEU HD1 . 16027 1
187 . 2 2 11 11 LEU HD13 H 1 0.78 0.01 . 1 . . . . 11 LEU HD1 . 16027 1
188 . 2 2 11 11 LEU HD21 H 1 0.78 0.01 . 1 . . . . 11 LEU HD2 . 16027 1
189 . 2 2 11 11 LEU HD22 H 1 0.78 0.01 . 1 . . . . 11 LEU HD2 . 16027 1
190 . 2 2 11 11 LEU HD23 H 1 0.78 0.01 . 1 . . . . 11 LEU HD2 . 16027 1
191 . 2 2 11 11 LEU HG H 1 1.39 0.01 . 1 . . . . 11 LEU HG . 16027 1
192 . 2 2 12 12 VAL H H 1 7.05 0.01 . 1 . . . . 12 VAL H . 16027 1
193 . 2 2 12 12 VAL HA H 1 3.41 0.01 . 1 . . . . 12 VAL HA . 16027 1
194 . 2 2 12 12 VAL HB H 1 2.11 0.01 . 1 . . . . 12 VAL HB . 16027 1
195 . 2 2 12 12 VAL HG11 H 1 0.94 0.01 . 2 . . . . 12 VAL HG1 . 16027 1
196 . 2 2 12 12 VAL HG12 H 1 0.94 0.01 . 2 . . . . 12 VAL HG1 . 16027 1
197 . 2 2 12 12 VAL HG13 H 1 0.94 0.01 . 2 . . . . 12 VAL HG1 . 16027 1
198 . 2 2 12 12 VAL HG21 H 1 0.89 0.01 . 2 . . . . 12 VAL HG2 . 16027 1
199 . 2 2 12 12 VAL HG22 H 1 0.89 0.01 . 2 . . . . 12 VAL HG2 . 16027 1
200 . 2 2 12 12 VAL HG23 H 1 0.89 0.01 . 2 . . . . 12 VAL HG2 . 16027 1
201 . 2 2 13 13 GLU H H 1 7.98 0.01 . 1 . . . . 13 GLU H . 16027 1
202 . 2 2 13 13 GLU HA H 1 4.05 0.01 . 1 . . . . 13 GLU HA . 16027 1
203 . 2 2 13 13 GLU HB2 H 1 2.10 0.01 . 1 . . . . 13 GLU HB2 . 16027 1
204 . 2 2 13 13 GLU HB3 H 1 2.10 0.01 . 1 . . . . 13 GLU HB3 . 16027 1
205 . 2 2 13 13 GLU HG2 H 1 2.43 0.01 . 2 . . . . 13 GLU HG2 . 16027 1
206 . 2 2 13 13 GLU HG3 H 1 2.31 0.01 . 2 . . . . 13 GLU HG3 . 16027 1
207 . 2 2 14 14 ALA H H 1 7.75 0.01 . 1 . . . . 14 ALA H . 16027 1
208 . 2 2 14 14 ALA HA H 1 4.11 0.01 . 1 . . . . 14 ALA HA . 16027 1
209 . 2 2 14 14 ALA HB1 H 1 1.42 0.01 . 1 . . . . 14 ALA HB . 16027 1
210 . 2 2 14 14 ALA HB2 H 1 1.42 0.01 . 1 . . . . 14 ALA HB . 16027 1
211 . 2 2 14 14 ALA HB3 H 1 1.42 0.01 . 1 . . . . 14 ALA HB . 16027 1
212 . 2 2 15 15 LEU H H 1 8.22 0.01 . 1 . . . . 15 LEU H . 16027 1
213 . 2 2 15 15 LEU HA H 1 3.99 0.01 . 1 . . . . 15 LEU HA . 16027 1
214 . 2 2 15 15 LEU HB2 H 1 1.75 0.01 . 2 . . . . 15 LEU HB2 . 16027 1
215 . 2 2 15 15 LEU HB3 H 1 1.39 0.01 . 2 . . . . 15 LEU HB3 . 16027 1
216 . 2 2 15 15 LEU HD11 H 1 0.71 0.01 . 1 . . . . 15 LEU HD1 . 16027 1
217 . 2 2 15 15 LEU HD12 H 1 0.71 0.01 . 1 . . . . 15 LEU HD1 . 16027 1
218 . 2 2 15 15 LEU HD13 H 1 0.71 0.01 . 1 . . . . 15 LEU HD1 . 16027 1
219 . 2 2 15 15 LEU HD21 H 1 0.71 0.01 . 1 . . . . 15 LEU HD2 . 16027 1
220 . 2 2 15 15 LEU HD22 H 1 0.71 0.01 . 1 . . . . 15 LEU HD2 . 16027 1
221 . 2 2 15 15 LEU HD23 H 1 0.71 0.01 . 1 . . . . 15 LEU HD2 . 16027 1
222 . 2 2 15 15 LEU HG H 1 1.62 0.01 . 1 . . . . 15 LEU HG . 16027 1
223 . 2 2 16 16 TYR H H 1 8.04 0.01 . 1 . . . . 16 TYR H . 16027 1
224 . 2 2 16 16 TYR HA H 1 4.29 0.01 . 1 . . . . 16 TYR HA . 16027 1
225 . 2 2 16 16 TYR HB2 H 1 3.16 0.01 . 1 . . . . 16 TYR HB2 . 16027 1
226 . 2 2 16 16 TYR HB3 H 1 3.16 0.01 . 1 . . . . 16 TYR HB3 . 16027 1
227 . 2 2 16 16 TYR HD1 H 1 7.14 0.01 . 1 . . . . 16 TYR HD1 . 16027 1
228 . 2 2 16 16 TYR HD2 H 1 7.14 0.01 . 1 . . . . 16 TYR HD2 . 16027 1
229 . 2 2 16 16 TYR HE1 H 1 6.78 0.01 . 1 . . . . 16 TYR HE1 . 16027 1
230 . 2 2 16 16 TYR HE2 H 1 6.78 0.01 . 1 . . . . 16 TYR HE2 . 16027 1
231 . 2 2 17 17 LEU H H 1 7.69 0.01 . 1 . . . . 17 LEU H . 16027 1
232 . 2 2 17 17 LEU HA H 1 4.09 0.01 . 1 . . . . 17 LEU HA . 16027 1
233 . 2 2 17 17 LEU HB2 H 1 1.93 0.01 . 2 . . . . 17 LEU HB2 . 16027 1
234 . 2 2 17 17 LEU HB3 H 1 1.73 0.01 . 2 . . . . 17 LEU HB3 . 16027 1
235 . 2 2 17 17 LEU HD11 H 1 0.93 0.01 . 1 . . . . 17 LEU HD1 . 16027 1
236 . 2 2 17 17 LEU HD12 H 1 0.93 0.01 . 1 . . . . 17 LEU HD1 . 16027 1
237 . 2 2 17 17 LEU HD13 H 1 0.93 0.01 . 1 . . . . 17 LEU HD1 . 16027 1
238 . 2 2 17 17 LEU HD21 H 1 0.93 0.01 . 1 . . . . 17 LEU HD2 . 16027 1
239 . 2 2 17 17 LEU HD22 H 1 0.93 0.01 . 1 . . . . 17 LEU HD2 . 16027 1
240 . 2 2 17 17 LEU HD23 H 1 0.93 0.01 . 1 . . . . 17 LEU HD2 . 16027 1
241 . 2 2 17 17 LEU HG H 1 1.79 0.01 . 1 . . . . 17 LEU HG . 16027 1
242 . 2 2 18 18 VAL H H 1 8.25 0.01 . 1 . . . . 18 VAL H . 16027 1
243 . 2 2 18 18 VAL HA H 1 3.82 0.01 . 1 . . . . 18 VAL HA . 16027 1
244 . 2 2 18 18 VAL HB H 1 2.07 0.01 . 1 . . . . 18 VAL HB . 16027 1
245 . 2 2 18 18 VAL HG11 H 1 1.03 0.01 . 2 . . . . 18 VAL HG1 . 16027 1
246 . 2 2 18 18 VAL HG12 H 1 1.03 0.01 . 2 . . . . 18 VAL HG1 . 16027 1
247 . 2 2 18 18 VAL HG13 H 1 1.03 0.01 . 2 . . . . 18 VAL HG1 . 16027 1
248 . 2 2 18 18 VAL HG21 H 1 0.90 0.01 . 2 . . . . 18 VAL HG2 . 16027 1
249 . 2 2 18 18 VAL HG22 H 1 0.90 0.01 . 2 . . . . 18 VAL HG2 . 16027 1
250 . 2 2 18 18 VAL HG23 H 1 0.90 0.01 . 2 . . . . 18 VAL HG2 . 16027 1
251 . 2 2 19 19 CYS H H 1 8.68 0.01 . 1 . . . . 19 CYS H . 16027 1
252 . 2 2 19 19 CYS HA H 1 4.73 0.01 . 1 . . . . 19 CYS HA . 16027 1
253 . 2 2 19 19 CYS HB2 H 1 3.16 0.01 . 2 . . . . 19 CYS HB2 . 16027 1
254 . 2 2 19 19 CYS HB3 H 1 2.83 0.01 . 2 . . . . 19 CYS HB3 . 16027 1
255 . 2 2 20 20 GLY H H 1 7.75 0.01 . 1 . . . . 20 GLY H . 16027 1
256 . 2 2 20 20 GLY HA2 H 1 3.94 0.01 . 2 . . . . 20 GLY HA1 . 16027 1
257 . 2 2 20 20 GLY HA3 H 1 3.79 0.01 . 2 . . . . 20 GLY HA2 . 16027 1
258 . 2 2 21 21 GLU HA H 1 4.16 0.01 . 1 . . . . 21 GLU HA . 16027 1
259 . 2 2 21 21 GLU HB2 H 1 2.12 0.01 . 2 . . . . 21 GLU HB2 . 16027 1
260 . 2 2 21 21 GLU HB3 H 1 2.02 0.01 . 2 . . . . 21 GLU HB3 . 16027 1
261 . 2 2 21 21 GLU HG2 H 1 2.31 0.01 . 2 . . . . 21 GLU HG2 . 16027 1
262 . 2 2 21 21 GLU HG3 H 1 2.31 0.01 . 2 . . . . 21 GLU HG3 . 16027 1
263 . 2 2 22 22 ARG H H 1 8.04 0.01 . 1 . . . . 22 ARG H . 16027 1
264 . 2 2 22 22 ARG HA H 1 4.26 0.01 . 1 . . . . 22 ARG HA . 16027 1
265 . 2 2 22 22 ARG HB2 H 1 2.03 0.01 . 2 . . . . 22 ARG HB2 . 16027 1
266 . 2 2 22 22 ARG HB3 H 1 1.92 0.01 . 2 . . . . 22 ARG HB3 . 16027 1
267 . 2 2 22 22 ARG HD2 H 1 3.23 0.01 . 1 . . . . 22 ARG HD2 . 16027 1
268 . 2 2 22 22 ARG HD3 H 1 3.23 0.01 . 1 . . . . 22 ARG HD3 . 16027 1
269 . 2 2 22 22 ARG HG2 H 1 1.75 0.01 . 1 . . . . 22 ARG HG2 . 16027 1
270 . 2 2 22 22 ARG HG3 H 1 1.75 0.01 . 1 . . . . 22 ARG HG3 . 16027 1
271 . 2 2 23 23 GLY H H 1 7.76 0.01 . 1 . . . . 23 GLY H . 16027 1
272 . 2 2 23 23 GLY HA2 H 1 3.93 0.01 . 2 . . . . 23 GLY HA1 . 16027 1
273 . 2 2 23 23 GLY HA3 H 1 3.80 0.01 . 2 . . . . 23 GLY HA2 . 16027 1
274 . 2 2 24 24 ALA H H 1 8.01 0.01 . 1 . . . . 24 ALA H . 16027 1
275 . 2 2 24 24 ALA HA H 1 4.57 0.01 . 1 . . . . 24 ALA HA . 16027 1
276 . 2 2 24 24 ALA HB1 H 1 1.29 0.01 . 1 . . . . 24 ALA HB . 16027 1
277 . 2 2 24 24 ALA HB2 H 1 1.29 0.01 . 1 . . . . 24 ALA HB . 16027 1
278 . 2 2 24 24 ALA HB3 H 1 1.29 0.01 . 1 . . . . 24 ALA HB . 16027 1
279 . 2 2 25 25 PHE H H 1 8.24 0.01 . 1 . . . . 25 PHE H . 16027 1
280 . 2 2 25 25 PHE HA H 1 4.62 0.01 . 1 . . . . 25 PHE HA . 16027 1
281 . 2 2 25 25 PHE HB2 H 1 3.08 0.01 . 1 . . . . 25 PHE HB2 . 16027 1
282 . 2 2 25 25 PHE HB3 H 1 3.08 0.01 . 1 . . . . 25 PHE HB3 . 16027 1
283 . 2 2 25 25 PHE HD1 H 1 7.16 0.01 . 1 . . . . 25 PHE HD1 . 16027 1
284 . 2 2 25 25 PHE HD2 H 1 7.16 0.01 . 1 . . . . 25 PHE HD2 . 16027 1
285 . 2 2 25 25 PHE HE1 H 1 7.31 0.01 . 1 . . . . 25 PHE HE1 . 16027 1
286 . 2 2 25 25 PHE HE2 H 1 7.31 0.01 . 1 . . . . 25 PHE HE2 . 16027 1
287 . 2 2 26 26 TYR HA H 1 4.51 0.01 . 1 . . . . 26 TYR HA . 16027 1
288 . 2 2 26 26 TYR HB2 H 1 2.91 0.01 . 1 . . . . 26 TYR HB2 . 16027 1
289 . 2 2 26 26 TYR HB3 H 1 2.91 0.01 . 1 . . . . 26 TYR HB3 . 16027 1
290 . 2 2 26 26 TYR HD1 H 1 6.97 0.01 . 1 . . . . 26 TYR HD1 . 16027 1
291 . 2 2 26 26 TYR HD2 H 1 6.97 0.01 . 1 . . . . 26 TYR HD2 . 16027 1
292 . 2 2 26 26 TYR HE1 H 1 6.72 0.01 . 1 . . . . 26 TYR HE1 . 16027 1
293 . 2 2 26 26 TYR HE2 H 1 6.72 0.01 . 1 . . . . 26 TYR HE2 . 16027 1
294 . 2 2 27 27 THR HA H 1 4.28 0.01 . 1 . . . . 27 THR HA . 16027 1
295 . 2 2 27 27 THR HB H 1 4.11 0.01 . 1 . . . . 27 THR HB . 16027 1
296 . 2 2 27 27 THR HG21 H 1 1.14 0.01 . 1 . . . . 27 THR HG2 . 16027 1
297 . 2 2 27 27 THR HG22 H 1 1.14 0.01 . 1 . . . . 27 THR HG2 . 16027 1
298 . 2 2 27 27 THR HG23 H 1 1.14 0.01 . 1 . . . . 27 THR HG2 . 16027 1
299 . 2 2 28 28 LYS HA H 1 4.42 0.01 . 1 . . . . 28 LYS HA . 16027 1
300 . 2 2 28 28 LYS HB2 H 1 1.80 0.01 . 2 . . . . 28 LYS HB2 . 16027 1
301 . 2 2 28 28 LYS HB3 H 1 1.70 0.01 . 2 . . . . 28 LYS HB3 . 16027 1
302 . 2 2 28 28 LYS HD2 H 1 1.70 0.01 . 1 . . . . 28 LYS HD2 . 16027 1
303 . 2 2 28 28 LYS HD3 H 1 1.70 0.01 . 1 . . . . 28 LYS HD3 . 16027 1
304 . 2 2 28 28 LYS HE2 H 1 2.97 0.01 . 1 . . . . 28 LYS HE2 . 16027 1
305 . 2 2 28 28 LYS HE3 H 1 2.97 0.01 . 1 . . . . 28 LYS HE3 . 16027 1
306 . 2 2 28 28 LYS HG2 H 1 1.44 0.01 . 1 . . . . 28 LYS HG2 . 16027 1
307 . 2 2 28 28 LYS HG3 H 1 1.44 0.01 . 1 . . . . 28 LYS HG3 . 16027 1
308 . 2 2 29 29 PRO HA H 1 4.49 0.01 . 1 . . . . 29 PRO HA . 16027 1
309 . 2 2 29 29 PRO HB2 H 1 2.28 0.01 . 2 . . . . 29 PRO HB2 . 16027 1
310 . 2 2 29 29 PRO HB3 H 1 2.07 0.01 . 2 . . . . 29 PRO HB3 . 16027 1
311 . 2 2 29 29 PRO HD2 H 1 3.83 0.01 . 2 . . . . 29 PRO HD2 . 16027 1
312 . 2 2 29 29 PRO HD3 H 1 3.67 0.01 . 2 . . . . 29 PRO HD3 . 16027 1
313 . 2 2 29 29 PRO HG2 H 1 1.99 0.01 . 1 . . . . 29 PRO HG2 . 16027 1
314 . 2 2 29 29 PRO HG3 H 1 1.99 0.01 . 1 . . . . 29 PRO HG3 . 16027 1
315 . 2 2 30 30 THR H H 1 7.74 0.01 . 1 . . . . 30 THR H . 16027 1
316 . 2 2 30 30 THR HA H 1 4.12 0.01 . 1 . . . . 30 THR HA . 16027 1
317 . 2 2 30 30 THR HB H 1 4.21 0.01 . 1 . . . . 30 THR HB . 16027 1
318 . 2 2 30 30 THR HG21 H 1 1.19 0.01 . 1 . . . . 30 THR HG2 . 16027 1
319 . 2 2 30 30 THR HG22 H 1 1.19 0.01 . 1 . . . . 30 THR HG2 . 16027 1
320 . 2 2 30 30 THR HG23 H 1 1.19 0.01 . 1 . . . . 30 THR HG2 . 16027 1
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