data_2498 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 2498 _Entry.Title ; 1H-NMR Assignment and Secondary structure of Human Insulin-Like Growth Factor-I (IGF-I) in Solution ; _Entry.Type macromolecule _Entry.Version_type update _Entry.Submission_date 1995-07-31 _Entry.Accession_date 1996-04-13 _Entry.Last_release_date . _Entry.Original_release_date . _Entry.Origination BMRB _Entry.NMR_STAR_version 3.1.1.61 _Entry.Original_NMR_STAR_version 2.1 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype . _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.Entry_ID 1 Akihiro Sato . . . 2498 2 Shigenori Nishimura . . . 2498 3 Tadayasu Ohkubo . . . 2498 4 Yoshimasa Kyogoku . . . 2498 5 Satoshi Koyama . . . 2498 6 Masakazu Kobayashi . . . 2498 7 Tsutomu Yasuda . . . 2498 8 Yuji Kobayashi . . . 2498 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID assigned_chemical_shifts 1 2498 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID '1H chemical shifts' 459 2498 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 5 . . 2010-06-17 . revision BMRB 'Complete natural source information' 2498 4 . . 1999-06-14 . revision BMRB 'Converted to BMRB NMR-STAR V 2.1 format' 2498 3 . . 1996-04-13 . revision BMRB 'Link to the Protein Data Bank added' 2498 2 . . 1996-03-25 . reformat BMRB 'Converted to the BMRB 1996-03-01 STAR flat-file format' 2498 1 . . 1995-07-31 . original BMRB 'Last release in original BMRB flat-file format' 2498 stop_ save_ ############### # Citations # ############### save_entry_citation _Citation.Sf_category citations _Citation.Sf_framecode entry_citation _Citation.Entry_ID 2498 _Citation.ID 1 _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.DOI . _Citation.PubMed_ID . _Citation.Full_citation ; Sato, Akihiro, Nishimura, Shigenori, Ohkubo, Tadayasu, Kyogoku, Yoshimasa, Koyama, Satoshi, Kobayashi, Masakazu, Yasuda, Tsutomu, Kobayashi, Yuji, "1H-NMR Assignment and Secondary structure of Human Insulin-Like Growth Factor-I (IGF-I) in Solution," J. Biochem. 111 (4), 529-536 (1992). ; _Citation.Title ; 1H-NMR Assignment and Secondary structure of Human Insulin-Like Growth Factor-I (IGF-I) in Solution ; _Citation.Status published _Citation.Type journal _Citation.Journal_abbrev 'J. Biochem.' _Citation.Journal_name_full . _Citation.Journal_volume 111 _Citation.Journal_issue 4 _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD . _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first 529 _Citation.Page_last 536 _Citation.Year 1992 _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.Entry_ID _Citation_author.Citation_ID 1 Akihiro Sato . . . 2498 1 2 Shigenori Nishimura . . . 2498 1 3 Tadayasu Ohkubo . . . 2498 1 4 Yoshimasa Kyogoku . . . 2498 1 5 Satoshi Koyama . . . 2498 1 6 Masakazu Kobayashi . . . 2498 1 7 Tsutomu Yasuda . . . 2498 1 8 Yuji Kobayashi . . . 2498 1 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_system_insulin-like_growth_factor-I _Assembly.Sf_category assembly _Assembly.Sf_framecode system_insulin-like_growth_factor-I _Assembly.Entry_ID 2498 _Assembly.ID 1 _Assembly.Name 'insulin-like growth factor-I' _Assembly.BMRB_code . _Assembly.Number_of_components . _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds . _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic . _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number . _Assembly.Details . _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 'insulin-like growth factor-I' 1 $insulin-like_growth_factor-I . . . . . . . . . 2498 1 stop_ loop_ _Assembly_common_name.Name _Assembly_common_name.Type _Assembly_common_name.Entry_ID _Assembly_common_name.Assembly_ID 'insulin-like growth factor-I' system 2498 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_insulin-like_growth_factor-I _Entity.Sf_category entity _Entity.Sf_framecode insulin-like_growth_factor-I _Entity.Entry_ID 2498 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name 'insulin-like growth factor-I' _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can ; GPETLCGAELVDALQFVCGD RGFYFNKPTGYGSSSRRAPQ TGIVDECCFRSCDLRRLEMY CAPLKPAKSA ; _Entity.Polymer_seq_one_letter_code ; GPETLCGAELVDALQFVCGD RGFYFNKPTGYGSSSRRAPQ TGIVDECCFRSCDLRRLEMY CAPLKPAKSA ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states . _Entity.Ambiguous_chem_comp_sites . _Entity.Nstd_monomer . _Entity.Nstd_chirality . _Entity.Nstd_linkage . _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 70 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic . _Entity.Thiol_state . _Entity.Src_method . _Entity.Parent_entity_ID 1 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight . _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date 2015-11-25 loop_ _Entity_db_link.Ordinal _Entity_db_link.Author_supplied _Entity_db_link.Database_code _Entity_db_link.Accession_code _Entity_db_link.Entry_mol_code _Entity_db_link.Entry_mol_name _Entity_db_link.Entry_experimental_method _Entity_db_link.Entry_structure_resolution _Entity_db_link.Entry_relation_type _Entity_db_link.Entry_details _Entity_db_link.Chimera_segment_ID _Entity_db_link.Seq_query_to_submitted_percent _Entity_db_link.Seq_subject_length _Entity_db_link.Seq_identity _Entity_db_link.Seq_positive _Entity_db_link.Seq_homology_expectation_val _Entity_db_link.Seq_align_begin _Entity_db_link.Seq_align_end _Entity_db_link.Seq_difference_details _Entity_db_link.Seq_alignment_details _Entity_db_link.Entry_ID _Entity_db_link.Entity_ID 1 no BMRB 15654 . Insulin-like_growth_factor-I_(IGF-I) . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 2 no BMRB 4069 . "Long-[Arg-3]-Insulin-Like Growth Factor-I" . . . . . 100.00 83 98.57 98.57 4.77e-42 . . . . 2498 1 3 no BMRB 4204 . "Insulin-like growth factor-I (Somatomedin C)" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 4 no BMRB 4278 . IGF-I . . . . . 100.00 83 98.57 98.57 7.52e-42 . . . . 2498 1 5 no BMRB 4494 . IGF-I . . . . . 100.00 83 98.57 98.57 4.77e-42 . . . . 2498 1 6 no PDB 1BQT . "Three-Dimensional Structure Of Human Insulin-Like Growth Factor-I (Igf-I) Determined By 1h-Nmr And Distance Geometry, 6 Structu" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 7 no PDB 1GZR . "Human Insulin-Like Growth Factor; Esrf Data" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 8 no PDB 1GZY . "Human Insulin-Like Growth Factor; In-House Data" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 9 no PDB 1GZZ . "Human Insulin-Like Growth Factor; Hamburg Data" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 10 no PDB 1H02 . "Human Insulin-Like Growth Factor; Srs Daresbury Data" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 11 no PDB 1H59 . "Complex Of Igfbp-5 With Igf-I" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 12 no PDB 1IMX . "1.8 Angstrom Crystal Structure Of Igf-1" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 13 no PDB 1PMX . "Insulin-Like Growth Factor-I Bound To A Phage-Derived Peptide" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 14 no PDB 1WQJ . "Structural Basis For The Regulation Of Insulin-Like Growth Factors (Igfs) By Igf Binding Proteins (Igfbps)" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 15 no PDB 2DSP . "Structural Basis For The Inhibition Of Insulin-Like Growth Factors By Igf Binding Proteins" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 16 no PDB 2DSQ . "Structural Basis For The Inhibition Of Insulin-Like Growth Factors By Igf Binding Proteins" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 17 no PDB 2DSR . "Structural Basis For The Inhibition Of Insulin-Like Growth Factors By Igf Binding Proteins" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 18 no PDB 2GF1 . "Solution Structure Of Human Insulin-Like Growth Factor 1: A Nuclear Magnetic Resonance And Restrained Molecular Dynamics Study" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 19 no PDB 3GF1 . "Solution Structure Of Human Insulin-Like Growth Factor 1: A Nuclear Magnetic Resonance And Restrained Molecular Dynamics Study" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 20 no PDB 3LRI . "Solution Structure And Backbone Dynamics Of Long-[arg(3) ]insulin-Like Growth Factor-I" . . . . . 100.00 83 97.14 97.14 2.21e-40 . . . . 2498 1 21 no PDB 4XSS . "Insulin-like Growth Factor I In Complex With Site 1 Of A Hybrid Insulin Receptor / Type 1 Insulin-like Growth Factor Receptor" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 22 no DBJ BAA01200 . "Met-somatomedin C polypeptide [synthetic construct]" . . . . . 100.00 71 100.00 100.00 9.21e-43 . . . . 2498 1 23 no DBJ BAA01976 . "prepro IGF-I [Capra hircus]" . . . . . 100.00 154 98.57 98.57 1.40e-42 . . . . 2498 1 24 no DBJ BAA07897 . "insulin-like growth factor I precursor [Suncus murinus]" . . . . . 100.00 81 98.57 100.00 1.32e-42 . . . . 2498 1 25 no DBJ BAB77524 . "insulin-like growth factor-I [Capra hircus]" . . . . . 100.00 159 98.57 98.57 1.16e-42 . . . . 2498 1 26 no DBJ BAD92421 . "insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1 (somatomedia C) variant [Homo sapiens]" . . . . . 100.00 184 100.00 100.00 6.19e-43 . . . . 2498 1 27 no EMBL CAA24998 . "insulin-like growth factor 1A precursor [Homo sapiens]" . . . . . 100.00 153 100.00 100.00 2.46e-43 . . . . 2498 1 28 no EMBL CAA27153 . "unnamed protein product [Homo sapiens]" . . . . . 62.86 60 100.00 100.00 2.04e-22 . . . . 2498 1 29 no EMBL CAA28759 . "unnamed protein product [synthetic construct]" . . . . . 100.00 137 100.00 100.00 3.80e-43 . . . . 2498 1 30 no EMBL CAA33746 . "prepro-insulin-like growth factor I [Bos taurus]" . . . . . 100.00 153 100.00 100.00 3.87e-43 . . . . 2498 1 31 no EMBL CAA35098 . "insuline-like growth factor-I (2) [Ovis aries]" . . . . . 100.00 138 98.57 98.57 9.22e-43 . . . . 2498 1 32 no GB AAA31043 . "insulin-like growth factor I precursor [Sus scrofa]" . . . . . 100.00 130 100.00 100.00 6.08e-44 . . . . 2498 1 33 no GB AAA31544 . "insulin-like growth factor I, partial [Ovis aries]" . . . . . 92.86 81 96.92 96.92 9.72e-38 . . . . 2498 1 34 no GB AAA31545 . "insulin-like growth factor I precursor [Ovis aries]" . . . . . 100.00 130 98.57 98.57 1.01e-42 . . . . 2498 1 35 no GB AAA31546 . "insulin-like growth factor I precursor A [Ovis aries]" . . . . . 100.00 154 98.57 98.57 3.71e-42 . . . . 2498 1 36 no GB AAA31547 . "insulin-like growth factor I precursor A' [Ovis aries]" . . . . . 100.00 130 98.57 98.57 1.01e-42 . . . . 2498 1 37 no PIR S22878 . "insulin-like growth factor I precursor, splice form 2 - sheep" . . . . . 100.00 138 98.57 98.57 9.22e-43 . . . . 2498 1 38 no PRF 0912651A . "somatomedin C" . . . . . 100.00 70 100.00 100.00 1.08e-42 . . . . 2498 1 39 no PRF 1001199A . "insulin-like growth factor I precursor" . . . . . 100.00 156 100.00 100.00 2.33e-43 . . . . 2498 1 40 no PRF 1203258A . "insulin-like growth factor I" . . . . . 100.00 130 100.00 100.00 6.22e-44 . . . . 2498 1 41 no PRF 1707201A . "insulin-like growth factor 1" . . . . . 100.00 70 97.14 97.14 4.97e-41 . . . . 2498 1 42 no PRF 2001274A . "insulin-like growth factor I" . . . . . 100.00 70 97.14 98.57 1.06e-41 . . . . 2498 1 43 no REF NP_000609 . "insulin-like growth factor I isoform 4 preproprotein [Homo sapiens]" . . . . . 100.00 153 100.00 100.00 2.46e-43 . . . . 2498 1 44 no REF NP_001009774 . "insulin-like growth factor I precursor [Ovis aries]" . . . . . 100.00 154 98.57 98.57 3.71e-42 . . . . 2498 1 45 no REF NP_001071296 . "insulin-like growth factor I preproprotein [Bos taurus]" . . . . . 100.00 154 100.00 100.00 3.94e-43 . . . . 2498 1 46 no REF NP_001075495 . "insulin-like growth factor I precursor [Oryctolagus cuniculus]" . . . . . 100.00 143 98.57 100.00 2.72e-43 . . . . 2498 1 47 no REF NP_001075967 . "insulin-like growth factor I precursor [Equus caballus]" . . . . . 100.00 153 100.00 100.00 2.51e-43 . . . . 2498 1 48 no SP P05019 . "RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Mechano growth factor; Short=MGF; AltName: Full=Somatome" . . . . . 100.00 195 100.00 100.00 9.16e-43 . . . . 2498 1 49 no SP P07455 . "RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Somatomedin; Flags: Precursor" . . . . . 100.00 154 100.00 100.00 3.94e-43 . . . . 2498 1 50 no SP P10763 . "RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Somatomedin; Flags: Precursor" . . . . . 100.00 154 98.57 98.57 3.71e-42 . . . . 2498 1 51 no SP P16545 . "RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Somatomedin; Flags: Precursor" . . . . . 100.00 153 100.00 100.00 2.54e-43 . . . . 2498 1 52 no SP P17647 . "RecName: Full=Insulin-like growth factor I; Short=IGF-I; AltName: Full=Somatomedin; Flags: Precursor" . . . . . 100.00 130 100.00 100.00 7.16e-44 . . . . 2498 1 53 no TPG DAA29731 . "TPA: insulin-like growth factor I precursor [Bos taurus]" . . . . . 100.00 154 100.00 100.00 3.94e-43 . . . . 2498 1 stop_ loop_ _Entity_common_name.Name _Entity_common_name.Type _Entity_common_name.Entry_ID _Entity_common_name.Entity_ID 'insulin-like growth factor-I' common 2498 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . GLY . 2498 1 2 . PRO . 2498 1 3 . GLU . 2498 1 4 . THR . 2498 1 5 . LEU . 2498 1 6 . CYS . 2498 1 7 . GLY . 2498 1 8 . ALA . 2498 1 9 . GLU . 2498 1 10 . LEU . 2498 1 11 . VAL . 2498 1 12 . ASP . 2498 1 13 . ALA . 2498 1 14 . LEU . 2498 1 15 . GLN . 2498 1 16 . PHE . 2498 1 17 . VAL . 2498 1 18 . CYS . 2498 1 19 . GLY . 2498 1 20 . ASP . 2498 1 21 . ARG . 2498 1 22 . GLY . 2498 1 23 . PHE . 2498 1 24 . TYR . 2498 1 25 . PHE . 2498 1 26 . ASN . 2498 1 27 . LYS . 2498 1 28 . PRO . 2498 1 29 . THR . 2498 1 30 . GLY . 2498 1 31 . TYR . 2498 1 32 . GLY . 2498 1 33 . SER . 2498 1 34 . SER . 2498 1 35 . SER . 2498 1 36 . ARG . 2498 1 37 . ARG . 2498 1 38 . ALA . 2498 1 39 . PRO . 2498 1 40 . GLN . 2498 1 41 . THR . 2498 1 42 . GLY . 2498 1 43 . ILE . 2498 1 44 . VAL . 2498 1 45 . ASP . 2498 1 46 . GLU . 2498 1 47 . CYS . 2498 1 48 . CYS . 2498 1 49 . PHE . 2498 1 50 . ARG . 2498 1 51 . SER . 2498 1 52 . CYS . 2498 1 53 . ASP . 2498 1 54 . LEU . 2498 1 55 . ARG . 2498 1 56 . ARG . 2498 1 57 . LEU . 2498 1 58 . GLU . 2498 1 59 . MET . 2498 1 60 . TYR . 2498 1 61 . CYS . 2498 1 62 . ALA . 2498 1 63 . PRO . 2498 1 64 . LEU . 2498 1 65 . LYS . 2498 1 66 . PRO . 2498 1 67 . ALA . 2498 1 68 . LYS . 2498 1 69 . SER . 2498 1 70 . ALA . 2498 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . GLY 1 1 2498 1 . PRO 2 2 2498 1 . GLU 3 3 2498 1 . THR 4 4 2498 1 . LEU 5 5 2498 1 . CYS 6 6 2498 1 . GLY 7 7 2498 1 . ALA 8 8 2498 1 . GLU 9 9 2498 1 . LEU 10 10 2498 1 . VAL 11 11 2498 1 . ASP 12 12 2498 1 . ALA 13 13 2498 1 . LEU 14 14 2498 1 . GLN 15 15 2498 1 . PHE 16 16 2498 1 . VAL 17 17 2498 1 . CYS 18 18 2498 1 . GLY 19 19 2498 1 . ASP 20 20 2498 1 . ARG 21 21 2498 1 . GLY 22 22 2498 1 . PHE 23 23 2498 1 . TYR 24 24 2498 1 . PHE 25 25 2498 1 . ASN 26 26 2498 1 . LYS 27 27 2498 1 . PRO 28 28 2498 1 . THR 29 29 2498 1 . GLY 30 30 2498 1 . TYR 31 31 2498 1 . GLY 32 32 2498 1 . SER 33 33 2498 1 . SER 34 34 2498 1 . SER 35 35 2498 1 . ARG 36 36 2498 1 . ARG 37 37 2498 1 . ALA 38 38 2498 1 . PRO 39 39 2498 1 . GLN 40 40 2498 1 . THR 41 41 2498 1 . GLY 42 42 2498 1 . ILE 43 43 2498 1 . VAL 44 44 2498 1 . ASP 45 45 2498 1 . GLU 46 46 2498 1 . CYS 47 47 2498 1 . CYS 48 48 2498 1 . PHE 49 49 2498 1 . ARG 50 50 2498 1 . SER 51 51 2498 1 . CYS 52 52 2498 1 . ASP 53 53 2498 1 . LEU 54 54 2498 1 . ARG 55 55 2498 1 . ARG 56 56 2498 1 . LEU 57 57 2498 1 . GLU 58 58 2498 1 . MET 59 59 2498 1 . TYR 60 60 2498 1 . CYS 61 61 2498 1 . ALA 62 62 2498 1 . PRO 63 63 2498 1 . LEU 64 64 2498 1 . LYS 65 65 2498 1 . PRO 66 66 2498 1 . ALA 67 67 2498 1 . LYS 68 68 2498 1 . SER 69 69 2498 1 . ALA 70 70 2498 1 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 2498 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Subvariant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Cellular_location _Entity_natural_src.Fragment _Entity_natural_src.Fraction _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Plasmid_details _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Dev_stage _Entity_natural_src.Details _Entity_natural_src.Citation_ID _Entity_natural_src.Citation_label _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $insulin-like_growth_factor-I . 9606 organism . 'Homo sapiens' human . . Eukaryota Metazoa Homo sapiens generic . . . . . . . . . . . . . . . . . . . . 2498 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 2498 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_subvariant _Entity_experimental_src.Host_org_organ _Entity_experimental_src.Host_org_tissue _Entity_experimental_src.Host_org_tissue_fraction _Entity_experimental_src.Host_org_cell_line _Entity_experimental_src.Host_org_cell_type _Entity_experimental_src.Host_org_cellular_location _Entity_experimental_src.Host_org_organelle _Entity_experimental_src.Host_org_gene _Entity_experimental_src.Host_org_culture_collection _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Host_org_dev_stage _Entity_experimental_src.Details _Entity_experimental_src.Citation_ID _Entity_experimental_src.Citation_label _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $insulin-like_growth_factor-I . 'not available' . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2498 1 stop_ save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_one _Sample.Sf_category sample _Sample.Sf_framecode sample_one _Sample.Entry_ID 2498 _Sample.ID 1 _Sample.Type solution _Sample.Sub_type . _Sample.Details . _Sample.Aggregate_sample_number . _Sample.Solvent_system . _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . save_ ####################### # Sample conditions # ####################### save_sample_condition_set_one _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_condition_set_one _Sample_condition_list.Entry_ID 2498 _Sample_condition_list.ID 1 _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID pH 3 . na 2498 1 temperature 313 . K 2498 1 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_spectrometer_list _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode spectrometer_list _NMR_spectrometer.Entry_ID 2498 _NMR_spectrometer.ID 1 _NMR_spectrometer.Details 'spectrometer information not available' _NMR_spectrometer.Manufacturer unknown _NMR_spectrometer.Model unknown _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 0 save_ save_NMR_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode NMR_spectrometer_list _NMR_spectrometer_list.Entry_ID 2498 _NMR_spectrometer_list.ID 1 loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 spectrometer_1 unknown unknown . 0 'spectrometer information not available' . . 2498 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 2498 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 . . . . . . . . . . . . 1 $sample_one . . . 1 $sample_condition_set_one . . . 1 $spectrometer_list . . . . . . . . . . . . . . . . 2498 1 stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chem_shift_reference_par_set_one _Chem_shift_reference.Sf_category chem_shift_reference _Chem_shift_reference.Sf_framecode chem_shift_reference_par_set_one _Chem_shift_reference.Entry_ID 2498 _Chem_shift_reference.ID 1 _Chem_shift_reference.Details . loop_ _Chem_shift_ref.Atom_type _Chem_shift_ref.Atom_isotope_number _Chem_shift_ref.Mol_common_name _Chem_shift_ref.Atom_group _Chem_shift_ref.Concentration_val _Chem_shift_ref.Concentration_units _Chem_shift_ref.Solvent _Chem_shift_ref.Rank _Chem_shift_ref.Chem_shift_units _Chem_shift_ref.Chem_shift_val _Chem_shift_ref.Ref_method _Chem_shift_ref.Ref_type _Chem_shift_ref.Indirect_shift_ratio _Chem_shift_ref.External_ref_loc _Chem_shift_ref.External_ref_sample_geometry _Chem_shift_ref.External_ref_axis _Chem_shift_ref.Indirect_shift_ratio_cit_ID _Chem_shift_ref.Indirect_shift_ratio_cit_label _Chem_shift_ref.Ref_correction_type _Chem_shift_ref.Correction_val _Chem_shift_ref.Correction_val_cit_ID _Chem_shift_ref.Correction_val_cit_label _Chem_shift_ref.Entry_ID _Chem_shift_ref.Chem_shift_reference_ID H . TSP . . . . . ppm 0 . . . . . . 1 $entry_citation . . 1 $entry_citation 2498 1 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_chemical_shift_assignment_data_set_one _Assigned_chem_shift_list.Sf_category assigned_chemical_shifts _Assigned_chem_shift_list.Sf_framecode 'chemical_shift_assignment_data_set_one' _Assigned_chem_shift_list.Entry_ID 2498 _Assigned_chem_shift_list.ID 1 _Assigned_chem_shift_list.Sample_condition_list_ID 1 _Assigned_chem_shift_list.Sample_condition_list_label $sample_condition_set_one _Assigned_chem_shift_list.Chem_shift_reference_ID 1 _Assigned_chem_shift_list.Chem_shift_reference_label $chem_shift_reference_par_set_one _Assigned_chem_shift_list.Chem_shift_1H_err . _Assigned_chem_shift_list.Chem_shift_13C_err . _Assigned_chem_shift_list.Chem_shift_15N_err . _Assigned_chem_shift_list.Chem_shift_31P_err . _Assigned_chem_shift_list.Chem_shift_2H_err . _Assigned_chem_shift_list.Chem_shift_19F_err . _Assigned_chem_shift_list.Error_derivation_method . _Assigned_chem_shift_list.Details . _Assigned_chem_shift_list.Text_data_format . _Assigned_chem_shift_list.Text_data . loop_ _Chem_shift_experiment.Experiment_ID _Chem_shift_experiment.Experiment_name _Chem_shift_experiment.Sample_ID _Chem_shift_experiment.Sample_label _Chem_shift_experiment.Sample_state _Chem_shift_experiment.Entry_ID _Chem_shift_experiment.Assigned_chem_shift_list_ID . . 1 $sample_one . 2498 1 stop_ loop_ _Atom_chem_shift.ID _Atom_chem_shift.Assembly_atom_ID _Atom_chem_shift.Entity_assembly_ID _Atom_chem_shift.Entity_ID _Atom_chem_shift.Comp_index_ID _Atom_chem_shift.Seq_ID _Atom_chem_shift.Comp_ID _Atom_chem_shift.Atom_ID _Atom_chem_shift.Atom_type _Atom_chem_shift.Atom_isotope_number _Atom_chem_shift.Val _Atom_chem_shift.Val_err _Atom_chem_shift.Assign_fig_of_merit _Atom_chem_shift.Ambiguity_code _Atom_chem_shift.Occupancy _Atom_chem_shift.Resonance_ID _Atom_chem_shift.Auth_entity_assembly_ID _Atom_chem_shift.Auth_asym_ID _Atom_chem_shift.Auth_seq_ID _Atom_chem_shift.Auth_comp_ID _Atom_chem_shift.Auth_atom_ID _Atom_chem_shift.Details _Atom_chem_shift.Entry_ID _Atom_chem_shift.Assigned_chem_shift_list_ID 1 . 1 1 1 1 GLY HA2 H 1 3.57 . . 2 . . . . . . . . 2498 1 2 . 1 1 1 1 GLY HA3 H 1 3.91 . . 2 . . . . . . . . 2498 1 3 . 1 1 2 2 PRO HA H 1 4.44 . . 1 . . . . . . . . 2498 1 4 . 1 1 2 2 PRO HB2 H 1 2.22 . . 1 . . . . . . . . 2498 1 5 . 1 1 2 2 PRO HB3 H 1 2.22 . . 1 . . . . . . . . 2498 1 6 . 1 1 2 2 PRO HG2 H 1 1.9 . . 2 . . . . . . . . 2498 1 7 . 1 1 2 2 PRO HG3 H 1 1.96 . . 2 . . . . . . . . 2498 1 8 . 1 1 2 2 PRO HD2 H 1 3.52 . . 2 . . . . . . . . 2498 1 9 . 1 1 2 2 PRO HD3 H 1 3.58 . . 2 . . . . . . . . 2498 1 10 . 1 1 3 3 GLU H H 1 8.54 . . 1 . . . . . . . . 2498 1 11 . 1 1 3 3 GLU HA H 1 4.47 . . 1 . . . . . . . . 2498 1 12 . 1 1 3 3 GLU HB2 H 1 1.94 . . 2 . . . . . . . . 2498 1 13 . 1 1 3 3 GLU HB3 H 1 2.11 . . 2 . . . . . . . . 2498 1 14 . 1 1 3 3 GLU HG2 H 1 2.41 . . 1 . . . . . . . . 2498 1 15 . 1 1 3 3 GLU HG3 H 1 2.41 . . 1 . . . . . . . . 2498 1 16 . 1 1 4 4 THR H H 1 7.92 . . 1 . . . . . . . . 2498 1 17 . 1 1 4 4 THR HA H 1 4.41 . . 1 . . . . . . . . 2498 1 18 . 1 1 4 4 THR HB H 1 4.25 . . 1 . . . . . . . . 2498 1 19 . 1 1 4 4 THR HG21 H 1 1.07 . . 1 . . . . . . . . 2498 1 20 . 1 1 4 4 THR HG22 H 1 1.07 . . 1 . . . . . . . . 2498 1 21 . 1 1 4 4 THR HG23 H 1 1.07 . . 1 . . . . . . . . 2498 1 22 . 1 1 5 5 LEU H H 1 8.2 . . 1 . . . . . . . . 2498 1 23 . 1 1 5 5 LEU HA H 1 4.37 . . 1 . . . . . . . . 2498 1 24 . 1 1 5 5 LEU HB2 H 1 1.53 . . 1 . . . . . . . . 2498 1 25 . 1 1 5 5 LEU HB3 H 1 1.53 . . 1 . . . . . . . . 2498 1 26 . 1 1 5 5 LEU HG H 1 1.4 . . 1 . . . . . . . . 2498 1 27 . 1 1 5 5 LEU HD11 H 1 .7 . . 1 . . . . . . . . 2498 1 28 . 1 1 5 5 LEU HD12 H 1 .7 . . 1 . . . . . . . . 2498 1 29 . 1 1 5 5 LEU HD13 H 1 .7 . . 1 . . . . . . . . 2498 1 30 . 1 1 5 5 LEU HD21 H 1 .7 . . 1 . . . . . . . . 2498 1 31 . 1 1 5 5 LEU HD22 H 1 .7 . . 1 . . . . . . . . 2498 1 32 . 1 1 5 5 LEU HD23 H 1 .7 . . 1 . . . . . . . . 2498 1 33 . 1 1 6 6 CYS H H 1 8.09 . . 1 . . . . . . . . 2498 1 34 . 1 1 6 6 CYS HA H 1 4.56 . . 1 . . . . . . . . 2498 1 35 . 1 1 6 6 CYS HB2 H 1 3 . . 1 . . . . . . . . 2498 1 36 . 1 1 6 6 CYS HB3 H 1 3 . . 1 . . . . . . . . 2498 1 37 . 1 1 7 7 GLY H H 1 8.49 . . 1 . . . . . . . . 2498 1 38 . 1 1 7 7 GLY HA2 H 1 3.87 . . 2 . . . . . . . . 2498 1 39 . 1 1 7 7 GLY HA3 H 1 3.67 . . 2 . . . . . . . . 2498 1 40 . 1 1 8 8 ALA H H 1 8.4 . . 1 . . . . . . . . 2498 1 41 . 1 1 8 8 ALA HA H 1 3.99 . . 1 . . . . . . . . 2498 1 42 . 1 1 8 8 ALA HB1 H 1 1.38 . . 1 . . . . . . . . 2498 1 43 . 1 1 8 8 ALA HB2 H 1 1.38 . . 1 . . . . . . . . 2498 1 44 . 1 1 8 8 ALA HB3 H 1 1.38 . . 1 . . . . . . . . 2498 1 45 . 1 1 9 9 GLU H H 1 7.97 . . 1 . . . . . . . . 2498 1 46 . 1 1 9 9 GLU HA H 1 4.01 . . 1 . . . . . . . . 2498 1 47 . 1 1 9 9 GLU HB2 H 1 2.16 . . 1 . . . . . . . . 2498 1 48 . 1 1 9 9 GLU HB3 H 1 2.16 . . 1 . . . . . . . . 2498 1 49 . 1 1 9 9 GLU HG2 H 1 2.52 . . 2 . . . . . . . . 2498 1 50 . 1 1 9 9 GLU HG3 H 1 2.44 . . 2 . . . . . . . . 2498 1 51 . 1 1 10 10 LEU H H 1 7.4 . . 1 . . . . . . . . 2498 1 52 . 1 1 10 10 LEU HA H 1 3.86 . . 1 . . . . . . . . 2498 1 53 . 1 1 10 10 LEU HB2 H 1 1.66 . . 1 . . . . . . . . 2498 1 54 . 1 1 10 10 LEU HB3 H 1 1.66 . . 1 . . . . . . . . 2498 1 55 . 1 1 10 10 LEU HG H 1 1.31 . . 1 . . . . . . . . 2498 1 56 . 1 1 10 10 LEU HD11 H 1 .64 . . 2 . . . . . . . . 2498 1 57 . 1 1 10 10 LEU HD12 H 1 .64 . . 2 . . . . . . . . 2498 1 58 . 1 1 10 10 LEU HD13 H 1 .64 . . 2 . . . . . . . . 2498 1 59 . 1 1 10 10 LEU HD21 H 1 .66 . . 2 . . . . . . . . 2498 1 60 . 1 1 10 10 LEU HD22 H 1 .66 . . 2 . . . . . . . . 2498 1 61 . 1 1 10 10 LEU HD23 H 1 .66 . . 2 . . . . . . . . 2498 1 62 . 1 1 11 11 VAL H H 1 7.42 . . 1 . . . . . . . . 2498 1 63 . 1 1 11 11 VAL HA H 1 3.3 . . 1 . . . . . . . . 2498 1 64 . 1 1 11 11 VAL HB H 1 2.01 . . 1 . . . . . . . . 2498 1 65 . 1 1 11 11 VAL HG11 H 1 .9 . . 1 . . . . . . . . 2498 1 66 . 1 1 11 11 VAL HG12 H 1 .9 . . 1 . . . . . . . . 2498 1 67 . 1 1 11 11 VAL HG13 H 1 .9 . . 1 . . . . . . . . 2498 1 68 . 1 1 11 11 VAL HG21 H 1 .9 . . 1 . . . . . . . . 2498 1 69 . 1 1 11 11 VAL HG22 H 1 .9 . . 1 . . . . . . . . 2498 1 70 . 1 1 11 11 VAL HG23 H 1 .9 . . 1 . . . . . . . . 2498 1 71 . 1 1 12 12 ASP H H 1 7.99 . . 1 . . . . . . . . 2498 1 72 . 1 1 12 12 ASP HA H 1 4.34 . . 1 . . . . . . . . 2498 1 73 . 1 1 12 12 ASP HB2 H 1 2.75 . . 2 . . . . . . . . 2498 1 74 . 1 1 12 12 ASP HB3 H 1 2.9 . . 2 . . . . . . . . 2498 1 75 . 1 1 13 13 ALA H H 1 7.86 . . 1 . . . . . . . . 2498 1 76 . 1 1 13 13 ALA HA H 1 4.03 . . 1 . . . . . . . . 2498 1 77 . 1 1 13 13 ALA HB1 H 1 1.32 . . 1 . . . . . . . . 2498 1 78 . 1 1 13 13 ALA HB2 H 1 1.32 . . 1 . . . . . . . . 2498 1 79 . 1 1 13 13 ALA HB3 H 1 1.32 . . 1 . . . . . . . . 2498 1 80 . 1 1 14 14 LEU H H 1 8.12 . . 1 . . . . . . . . 2498 1 81 . 1 1 14 14 LEU HA H 1 3.78 . . 1 . . . . . . . . 2498 1 82 . 1 1 14 14 LEU HB2 H 1 1.2 . . 1 . . . . . . . . 2498 1 83 . 1 1 14 14 LEU HB3 H 1 1.2 . . 1 . . . . . . . . 2498 1 84 . 1 1 14 14 LEU HG H 1 1.38 . . 1 . . . . . . . . 2498 1 85 . 1 1 14 14 LEU HD11 H 1 .36 . . 2 . . . . . . . . 2498 1 86 . 1 1 14 14 LEU HD12 H 1 .36 . . 2 . . . . . . . . 2498 1 87 . 1 1 14 14 LEU HD13 H 1 .36 . . 2 . . . . . . . . 2498 1 88 . 1 1 14 14 LEU HD21 H 1 .58 . . 2 . . . . . . . . 2498 1 89 . 1 1 14 14 LEU HD22 H 1 .58 . . 2 . . . . . . . . 2498 1 90 . 1 1 14 14 LEU HD23 H 1 .58 . . 2 . . . . . . . . 2498 1 91 . 1 1 15 15 GLN H H 1 8.07 . . 1 . . . . . . . . 2498 1 92 . 1 1 15 15 GLN HA H 1 4.04 . . 1 . . . . . . . . 2498 1 93 . 1 1 15 15 GLN HB2 H 1 2.02 . . 2 . . . . . . . . 2498 1 94 . 1 1 15 15 GLN HB3 H 1 2.16 . . 2 . . . . . . . . 2498 1 95 . 1 1 15 15 GLN HG2 H 1 2.45 . . 2 . . . . . . . . 2498 1 96 . 1 1 15 15 GLN HG3 H 1 2.35 . . 2 . . . . . . . . 2498 1 97 . 1 1 15 15 GLN HE21 H 1 6.66 . . 2 . . . . . . . . 2498 1 98 . 1 1 15 15 GLN HE22 H 1 7.12 . . 2 . . . . . . . . 2498 1 99 . 1 1 16 16 PHE H H 1 7.64 . . 1 . . . . . . . . 2498 1 100 . 1 1 16 16 PHE HA H 1 4.36 . . 1 . . . . . . . . 2498 1 101 . 1 1 16 16 PHE HB2 H 1 3.17 . . 1 . . . . . . . . 2498 1 102 . 1 1 16 16 PHE HB3 H 1 3.17 . . 1 . . . . . . . . 2498 1 103 . 1 1 16 16 PHE HD1 H 1 7.14 . . 1 . . . . . . . . 2498 1 104 . 1 1 16 16 PHE HD2 H 1 7.14 . . 1 . . . . . . . . 2498 1 105 . 1 1 16 16 PHE HE1 H 1 7.18 . . 1 . . . . . . . . 2498 1 106 . 1 1 16 16 PHE HE2 H 1 7.18 . . 1 . . . . . . . . 2498 1 107 . 1 1 17 17 VAL H H 1 8.45 . . 1 . . . . . . . . 2498 1 108 . 1 1 17 17 VAL HA H 1 3.63 . . 1 . . . . . . . . 2498 1 109 . 1 1 17 17 VAL HB H 1 2.02 . . 1 . . . . . . . . 2498 1 110 . 1 1 17 17 VAL HG11 H 1 .87 . . 2 . . . . . . . . 2498 1 111 . 1 1 17 17 VAL HG12 H 1 .87 . . 2 . . . . . . . . 2498 1 112 . 1 1 17 17 VAL HG13 H 1 .87 . . 2 . . . . . . . . 2498 1 113 . 1 1 17 17 VAL HG21 H 1 1.04 . . 2 . . . . . . . . 2498 1 114 . 1 1 17 17 VAL HG22 H 1 1.04 . . 2 . . . . . . . . 2498 1 115 . 1 1 17 17 VAL HG23 H 1 1.04 . . 2 . . . . . . . . 2498 1 116 . 1 1 18 18 CYS H H 1 8.49 . . 1 . . . . . . . . 2498 1 117 . 1 1 18 18 CYS HA H 1 4.78 . . 1 . . . . . . . . 2498 1 118 . 1 1 18 18 CYS HB2 H 1 3.28 . . 2 . . . . . . . . 2498 1 119 . 1 1 18 18 CYS HB3 H 1 2.87 . . 2 . . . . . . . . 2498 1 120 . 1 1 19 19 GLY H H 1 7.65 . . 1 . . . . . . . . 2498 1 121 . 1 1 19 19 GLY HA2 H 1 3.93 . . 1 . . . . . . . . 2498 1 122 . 1 1 19 19 GLY HA3 H 1 3.93 . . 1 . . . . . . . . 2498 1 123 . 1 1 20 20 ASP H H 1 8.63 . . 1 . . . . . . . . 2498 1 124 . 1 1 20 20 ASP HA H 1 4.53 . . 1 . . . . . . . . 2498 1 125 . 1 1 20 20 ASP HB2 H 1 2.86 . . 1 . . . . . . . . 2498 1 126 . 1 1 20 20 ASP HB3 H 1 2.86 . . 1 . . . . . . . . 2498 1 127 . 1 1 21 21 ARG H H 1 7.98 . . 1 . . . . . . . . 2498 1 128 . 1 1 21 21 ARG HA H 1 4.16 . . 1 . . . . . . . . 2498 1 129 . 1 1 21 21 ARG HB2 H 1 1.89 . . 1 . . . . . . . . 2498 1 130 . 1 1 21 21 ARG HB3 H 1 1.89 . . 1 . . . . . . . . 2498 1 131 . 1 1 21 21 ARG HG2 H 1 1.74 . . 1 . . . . . . . . 2498 1 132 . 1 1 21 21 ARG HG3 H 1 1.74 . . 1 . . . . . . . . 2498 1 133 . 1 1 21 21 ARG HD2 H 1 3.23 . . 1 . . . . . . . . 2498 1 134 . 1 1 21 21 ARG HD3 H 1 3.23 . . 1 . . . . . . . . 2498 1 135 . 1 1 21 21 ARG HE H 1 7.07 . . 1 . . . . . . . . 2498 1 136 . 1 1 22 22 GLY H H 1 7.45 . . 1 . . . . . . . . 2498 1 137 . 1 1 22 22 GLY HA2 H 1 3.95 . . 2 . . . . . . . . 2498 1 138 . 1 1 22 22 GLY HA3 H 1 3.72 . . 2 . . . . . . . . 2498 1 139 . 1 1 23 23 PHE H H 1 7.48 . . 1 . . . . . . . . 2498 1 140 . 1 1 23 23 PHE HA H 1 4.99 . . 1 . . . . . . . . 2498 1 141 . 1 1 23 23 PHE HB2 H 1 3.09 . . 2 . . . . . . . . 2498 1 142 . 1 1 23 23 PHE HB3 H 1 2.82 . . 2 . . . . . . . . 2498 1 143 . 1 1 23 23 PHE HD1 H 1 6.79 . . 1 . . . . . . . . 2498 1 144 . 1 1 23 23 PHE HD2 H 1 6.79 . . 1 . . . . . . . . 2498 1 145 . 1 1 23 23 PHE HE1 H 1 7.12 . . 1 . . . . . . . . 2498 1 146 . 1 1 23 23 PHE HE2 H 1 7.12 . . 1 . . . . . . . . 2498 1 147 . 1 1 23 23 PHE HZ H 1 7.07 . . 1 . . . . . . . . 2498 1 148 . 1 1 24 24 TYR H H 1 8.38 . . 1 . . . . . . . . 2498 1 149 . 1 1 24 24 TYR HA H 1 4.63 . . 1 . . . . . . . . 2498 1 150 . 1 1 24 24 TYR HB2 H 1 2.85 . . 2 . . . . . . . . 2498 1 151 . 1 1 24 24 TYR HB3 H 1 3.02 . . 2 . . . . . . . . 2498 1 152 . 1 1 24 24 TYR HD1 H 1 6.99 . . 1 . . . . . . . . 2498 1 153 . 1 1 24 24 TYR HD2 H 1 6.99 . . 1 . . . . . . . . 2498 1 154 . 1 1 24 24 TYR HE1 H 1 6.72 . . 1 . . . . . . . . 2498 1 155 . 1 1 24 24 TYR HE2 H 1 6.72 . . 1 . . . . . . . . 2498 1 156 . 1 1 25 25 PHE H H 1 8.11 . . 1 . . . . . . . . 2498 1 157 . 1 1 25 25 PHE HA H 1 4.64 . . 1 . . . . . . . . 2498 1 158 . 1 1 25 25 PHE HB2 H 1 3.08 . . 2 . . . . . . . . 2498 1 159 . 1 1 25 25 PHE HB3 H 1 2.91 . . 2 . . . . . . . . 2498 1 160 . 1 1 25 25 PHE HD1 H 1 7.09 . . 1 . . . . . . . . 2498 1 161 . 1 1 25 25 PHE HD2 H 1 7.09 . . 1 . . . . . . . . 2498 1 162 . 1 1 26 26 ASN H H 1 8.04 . . 1 . . . . . . . . 2498 1 163 . 1 1 26 26 ASN HA H 1 4.75 . . 1 . . . . . . . . 2498 1 164 . 1 1 26 26 ASN HB2 H 1 2.61 . . 2 . . . . . . . . 2498 1 165 . 1 1 26 26 ASN HB3 H 1 2.71 . . 2 . . . . . . . . 2498 1 166 . 1 1 26 26 ASN HD21 H 1 6.78 . . 2 . . . . . . . . 2498 1 167 . 1 1 26 26 ASN HD22 H 1 7.41 . . 2 . . . . . . . . 2498 1 168 . 1 1 27 27 LYS H H 1 8.05 . . 1 . . . . . . . . 2498 1 169 . 1 1 27 27 LYS HA H 1 4.45 . . 1 . . . . . . . . 2498 1 170 . 1 1 27 27 LYS HB2 H 1 1.61 . . 2 . . . . . . . . 2498 1 171 . 1 1 27 27 LYS HB3 H 1 1.71 . . 2 . . . . . . . . 2498 1 172 . 1 1 27 27 LYS HG2 H 1 1.34 . . 1 . . . . . . . . 2498 1 173 . 1 1 27 27 LYS HG3 H 1 1.34 . . 1 . . . . . . . . 2498 1 174 . 1 1 27 27 LYS HD2 H 1 1.56 . . 1 . . . . . . . . 2498 1 175 . 1 1 27 27 LYS HD3 H 1 1.56 . . 1 . . . . . . . . 2498 1 176 . 1 1 27 27 LYS HE2 H 1 2.89 . . 1 . . . . . . . . 2498 1 177 . 1 1 27 27 LYS HE3 H 1 2.89 . . 1 . . . . . . . . 2498 1 178 . 1 1 28 28 PRO HA H 1 4.42 . . 1 . . . . . . . . 2498 1 179 . 1 1 28 28 PRO HB2 H 1 2.15 . . 1 . . . . . . . . 2498 1 180 . 1 1 28 28 PRO HB3 H 1 2.15 . . 1 . . . . . . . . 2498 1 181 . 1 1 28 28 PRO HG2 H 1 1.87 . . 2 . . . . . . . . 2498 1 182 . 1 1 28 28 PRO HG3 H 1 1.94 . . 2 . . . . . . . . 2498 1 183 . 1 1 28 28 PRO HD2 H 1 3.54 . . 2 . . . . . . . . 2498 1 184 . 1 1 28 28 PRO HD3 H 1 3.69 . . 2 . . . . . . . . 2498 1 185 . 1 1 29 29 THR H H 1 8.01 . . 1 . . . . . . . . 2498 1 186 . 1 1 29 29 THR HA H 1 4.28 . . 1 . . . . . . . . 2498 1 187 . 1 1 29 29 THR HB H 1 4.15 . . 1 . . . . . . . . 2498 1 188 . 1 1 29 29 THR HG21 H 1 1.14 . . 1 . . . . . . . . 2498 1 189 . 1 1 29 29 THR HG22 H 1 1.14 . . 1 . . . . . . . . 2498 1 190 . 1 1 29 29 THR HG23 H 1 1.14 . . 1 . . . . . . . . 2498 1 191 . 1 1 30 30 GLY H H 1 8.15 . . 1 . . . . . . . . 2498 1 192 . 1 1 30 30 GLY HA2 H 1 3.86 . . 2 . . . . . . . . 2498 1 193 . 1 1 30 30 GLY HA3 H 1 3.91 . . 2 . . . . . . . . 2498 1 194 . 1 1 31 31 TYR H H 1 7.99 . . 1 . . . . . . . . 2498 1 195 . 1 1 31 31 TYR HA H 1 4.51 . . 1 . . . . . . . . 2498 1 196 . 1 1 31 31 TYR HB2 H 1 2.91 . . 2 . . . . . . . . 2498 1 197 . 1 1 31 31 TYR HB3 H 1 3.01 . . 2 . . . . . . . . 2498 1 198 . 1 1 31 31 TYR HD1 H 1 7.04 . . 1 . . . . . . . . 2498 1 199 . 1 1 31 31 TYR HD2 H 1 7.04 . . 1 . . . . . . . . 2498 1 200 . 1 1 31 31 TYR HE1 H 1 6.77 . . 1 . . . . . . . . 2498 1 201 . 1 1 31 31 TYR HE2 H 1 6.77 . . 1 . . . . . . . . 2498 1 202 . 1 1 32 32 GLY H H 1 8.26 . . 1 . . . . . . . . 2498 1 203 . 1 1 32 32 GLY HA2 H 1 3.86 . . 2 . . . . . . . . 2498 1 204 . 1 1 32 32 GLY HA3 H 1 3.94 . . 2 . . . . . . . . 2498 1 205 . 1 1 33 33 SER H H 1 8.11 . . 1 . . . . . . . . 2498 1 206 . 1 1 33 33 SER HA H 1 4.42 . . 1 . . . . . . . . 2498 1 207 . 1 1 33 33 SER HB2 H 1 3.89 . . 2 . . . . . . . . 2498 1 208 . 1 1 33 33 SER HB3 H 1 3.82 . . 2 . . . . . . . . 2498 1 209 . 1 1 34 34 SER H H 1 8.27 . . 1 . . . . . . . . 2498 1 210 . 1 1 34 34 SER HA H 1 4.46 . . 1 . . . . . . . . 2498 1 211 . 1 1 34 34 SER HB2 H 1 3.93 . . 2 . . . . . . . . 2498 1 212 . 1 1 34 34 SER HB3 H 1 3.85 . . 2 . . . . . . . . 2498 1 213 . 1 1 35 35 SER H H 1 8.09 . . 1 . . . . . . . . 2498 1 214 . 1 1 35 35 SER HA H 1 4.39 . . 1 . . . . . . . . 2498 1 215 . 1 1 35 35 SER HB2 H 1 3.87 . . 2 . . . . . . . . 2498 1 216 . 1 1 35 35 SER HB3 H 1 3.81 . . 2 . . . . . . . . 2498 1 217 . 1 1 36 36 ARG H H 1 8.07 . . 1 . . . . . . . . 2498 1 218 . 1 1 36 36 ARG HA H 1 4.28 . . 1 . . . . . . . . 2498 1 219 . 1 1 36 36 ARG HB2 H 1 1.7 . . 2 . . . . . . . . 2498 1 220 . 1 1 36 36 ARG HB3 H 1 1.82 . . 2 . . . . . . . . 2498 1 221 . 1 1 36 36 ARG HG2 H 1 1.57 . . 1 . . . . . . . . 2498 1 222 . 1 1 36 36 ARG HG3 H 1 1.57 . . 1 . . . . . . . . 2498 1 223 . 1 1 36 36 ARG HD2 H 1 3.17 . . 1 . . . . . . . . 2498 1 224 . 1 1 36 36 ARG HD3 H 1 3.17 . . 1 . . . . . . . . 2498 1 225 . 1 1 36 36 ARG HE H 1 7.14 . . 1 . . . . . . . . 2498 1 226 . 1 1 37 37 ARG H H 1 8.03 . . 1 . . . . . . . . 2498 1 227 . 1 1 37 37 ARG HA H 1 4.29 . . 1 . . . . . . . . 2498 1 228 . 1 1 37 37 ARG HB2 H 1 1.55 . . 2 . . . . . . . . 2498 1 229 . 1 1 37 37 ARG HB3 H 1 1.66 . . 2 . . . . . . . . 2498 1 230 . 1 1 37 37 ARG HG2 H 1 1.76 . . 1 . . . . . . . . 2498 1 231 . 1 1 37 37 ARG HG3 H 1 1.76 . . 1 . . . . . . . . 2498 1 232 . 1 1 37 37 ARG HD2 H 1 3.12 . . 1 . . . . . . . . 2498 1 233 . 1 1 37 37 ARG HD3 H 1 3.12 . . 1 . . . . . . . . 2498 1 234 . 1 1 37 37 ARG HE H 1 7.08 . . 1 . . . . . . . . 2498 1 235 . 1 1 38 38 ALA H H 1 8.03 . . 1 . . . . . . . . 2498 1 236 . 1 1 38 38 ALA HA H 1 4.54 . . 1 . . . . . . . . 2498 1 237 . 1 1 38 38 ALA HB1 H 1 1.29 . . 1 . . . . . . . . 2498 1 238 . 1 1 38 38 ALA HB2 H 1 1.29 . . 1 . . . . . . . . 2498 1 239 . 1 1 38 38 ALA HB3 H 1 1.29 . . 1 . . . . . . . . 2498 1 240 . 1 1 39 39 PRO HA H 1 4.38 . . 1 . . . . . . . . 2498 1 241 . 1 1 39 39 PRO HB2 H 1 2.2 . . 1 . . . . . . . . 2498 1 242 . 1 1 39 39 PRO HB3 H 1 2.2 . . 1 . . . . . . . . 2498 1 243 . 1 1 39 39 PRO HG2 H 1 1.83 . . 2 . . . . . . . . 2498 1 244 . 1 1 39 39 PRO HG3 H 1 1.94 . . 2 . . . . . . . . 2498 1 245 . 1 1 39 39 PRO HD2 H 1 3.58 . . 2 . . . . . . . . 2498 1 246 . 1 1 39 39 PRO HD3 H 1 3.71 . . 2 . . . . . . . . 2498 1 247 . 1 1 40 40 GLN H H 1 8.37 . . 1 . . . . . . . . 2498 1 248 . 1 1 40 40 GLN HA H 1 4.33 . . 1 . . . . . . . . 2498 1 249 . 1 1 40 40 GLN HB2 H 1 1.93 . . 2 . . . . . . . . 2498 1 250 . 1 1 40 40 GLN HB3 H 1 2.08 . . 2 . . . . . . . . 2498 1 251 . 1 1 40 40 GLN HG2 H 1 2.32 . . 1 . . . . . . . . 2498 1 252 . 1 1 40 40 GLN HG3 H 1 2.32 . . 1 . . . . . . . . 2498 1 253 . 1 1 40 40 GLN HE21 H 1 6.71 . . 2 . . . . . . . . 2498 1 254 . 1 1 40 40 GLN HE22 H 1 7.35 . . 2 . . . . . . . . 2498 1 255 . 1 1 41 41 THR H H 1 7.93 . . 1 . . . . . . . . 2498 1 256 . 1 1 41 41 THR HA H 1 4.29 . . 1 . . . . . . . . 2498 1 257 . 1 1 41 41 THR HB H 1 4.2 . . 1 . . . . . . . . 2498 1 258 . 1 1 41 41 THR HG21 H 1 1.16 . . 1 . . . . . . . . 2498 1 259 . 1 1 41 41 THR HG22 H 1 1.16 . . 1 . . . . . . . . 2498 1 260 . 1 1 41 41 THR HG23 H 1 1.16 . . 1 . . . . . . . . 2498 1 261 . 1 1 42 42 GLY H H 1 8.34 . . 1 . . . . . . . . 2498 1 262 . 1 1 42 42 GLY HA2 H 1 4.02 . . 2 . . . . . . . . 2498 1 263 . 1 1 42 42 GLY HA3 H 1 4.09 . . 2 . . . . . . . . 2498 1 264 . 1 1 43 43 ILE H H 1 7.78 . . 1 . . . . . . . . 2498 1 265 . 1 1 43 43 ILE HA H 1 3.88 . . 1 . . . . . . . . 2498 1 266 . 1 1 43 43 ILE HB H 1 1.36 . . 1 . . . . . . . . 2498 1 267 . 1 1 43 43 ILE HG12 H 1 .94 . . 2 . . . . . . . . 2498 1 268 . 1 1 43 43 ILE HG13 H 1 1.17 . . 2 . . . . . . . . 2498 1 269 . 1 1 43 43 ILE HG21 H 1 .69 . . 1 . . . . . . . . 2498 1 270 . 1 1 43 43 ILE HG22 H 1 .69 . . 1 . . . . . . . . 2498 1 271 . 1 1 43 43 ILE HG23 H 1 .69 . . 1 . . . . . . . . 2498 1 272 . 1 1 43 43 ILE HD11 H 1 .61 . . 1 . . . . . . . . 2498 1 273 . 1 1 43 43 ILE HD12 H 1 .61 . . 1 . . . . . . . . 2498 1 274 . 1 1 43 43 ILE HD13 H 1 .61 . . 1 . . . . . . . . 2498 1 275 . 1 1 44 44 VAL H H 1 7.77 . . 1 . . . . . . . . 2498 1 276 . 1 1 44 44 VAL HA H 1 3.58 . . 1 . . . . . . . . 2498 1 277 . 1 1 44 44 VAL HB H 1 1.91 . . 1 . . . . . . . . 2498 1 278 . 1 1 44 44 VAL HG11 H 1 .71 . . 2 . . . . . . . . 2498 1 279 . 1 1 44 44 VAL HG12 H 1 .71 . . 2 . . . . . . . . 2498 1 280 . 1 1 44 44 VAL HG13 H 1 .71 . . 2 . . . . . . . . 2498 1 281 . 1 1 44 44 VAL HG21 H 1 .81 . . 2 . . . . . . . . 2498 1 282 . 1 1 44 44 VAL HG22 H 1 .81 . . 2 . . . . . . . . 2498 1 283 . 1 1 44 44 VAL HG23 H 1 .81 . . 2 . . . . . . . . 2498 1 284 . 1 1 45 45 ASP H H 1 7.89 . . 1 . . . . . . . . 2498 1 285 . 1 1 45 45 ASP HA H 1 4.44 . . 1 . . . . . . . . 2498 1 286 . 1 1 45 45 ASP HB2 H 1 2.81 . . 2 . . . . . . . . 2498 1 287 . 1 1 45 45 ASP HB3 H 1 3.01 . . 2 . . . . . . . . 2498 1 288 . 1 1 46 46 GLU H H 1 7.88 . . 1 . . . . . . . . 2498 1 289 . 1 1 46 46 GLU HA H 1 4.11 . . 1 . . . . . . . . 2498 1 290 . 1 1 46 46 GLU HB2 H 1 2.05 . . 1 . . . . . . . . 2498 1 291 . 1 1 46 46 GLU HB3 H 1 2.05 . . 1 . . . . . . . . 2498 1 292 . 1 1 46 46 GLU HG2 H 1 2.45 . . 1 . . . . . . . . 2498 1 293 . 1 1 46 46 GLU HG3 H 1 2.45 . . 1 . . . . . . . . 2498 1 294 . 1 1 47 47 CYS H H 1 8.13 . . 1 . . . . . . . . 2498 1 295 . 1 1 47 47 CYS HA H 1 4.8 . . 1 . . . . . . . . 2498 1 296 . 1 1 47 47 CYS HB2 H 1 3 . . 2 . . . . . . . . 2498 1 297 . 1 1 47 47 CYS HB3 H 1 3.2 . . 2 . . . . . . . . 2498 1 298 . 1 1 48 48 CYS H H 1 7.91 . . 1 . . . . . . . . 2498 1 299 . 1 1 48 48 CYS HA H 1 4.5 . . 1 . . . . . . . . 2498 1 300 . 1 1 48 48 CYS HB2 H 1 2.7 . . 2 . . . . . . . . 2498 1 301 . 1 1 48 48 CYS HB3 H 1 3.19 . . 2 . . . . . . . . 2498 1 302 . 1 1 49 49 PHE H H 1 7.73 . . 1 . . . . . . . . 2498 1 303 . 1 1 49 49 PHE HA H 1 4.63 . . 1 . . . . . . . . 2498 1 304 . 1 1 49 49 PHE HB2 H 1 3.32 . . 2 . . . . . . . . 2498 1 305 . 1 1 49 49 PHE HB3 H 1 3.02 . . 2 . . . . . . . . 2498 1 306 . 1 1 49 49 PHE HD1 H 1 7.21 . . 1 . . . . . . . . 2498 1 307 . 1 1 49 49 PHE HD2 H 1 7.21 . . 1 . . . . . . . . 2498 1 308 . 1 1 50 50 ARG H H 1 7.65 . . 1 . . . . . . . . 2498 1 309 . 1 1 50 50 ARG HA H 1 4.46 . . 1 . . . . . . . . 2498 1 310 . 1 1 50 50 ARG HB2 H 1 1.81 . . 2 . . . . . . . . 2498 1 311 . 1 1 50 50 ARG HB3 H 1 1.9 . . 2 . . . . . . . . 2498 1 312 . 1 1 50 50 ARG HG2 H 1 1.6 . . 1 . . . . . . . . 2498 1 313 . 1 1 50 50 ARG HG3 H 1 1.6 . . 1 . . . . . . . . 2498 1 314 . 1 1 50 50 ARG HD2 H 1 3.17 . . 1 . . . . . . . . 2498 1 315 . 1 1 50 50 ARG HD3 H 1 3.17 . . 1 . . . . . . . . 2498 1 316 . 1 1 50 50 ARG HE H 1 7.14 . . 1 . . . . . . . . 2498 1 317 . 1 1 51 51 SER H H 1 7.83 . . 1 . . . . . . . . 2498 1 318 . 1 1 51 51 SER HA H 1 4.45 . . 1 . . . . . . . . 2498 1 319 . 1 1 51 51 SER HB2 H 1 3.76 . . 1 . . . . . . . . 2498 1 320 . 1 1 51 51 SER HB3 H 1 3.76 . . 1 . . . . . . . . 2498 1 321 . 1 1 52 52 CYS H H 1 8.87 . . 1 . . . . . . . . 2498 1 322 . 1 1 52 52 CYS HA H 1 4.88 . . 1 . . . . . . . . 2498 1 323 . 1 1 52 52 CYS HB2 H 1 3.14 . . 2 . . . . . . . . 2498 1 324 . 1 1 52 52 CYS HB3 H 1 3.28 . . 2 . . . . . . . . 2498 1 325 . 1 1 53 53 ASP H H 1 8 . . 1 . . . . . . . . 2498 1 326 . 1 1 53 53 ASP HA H 1 4.66 . . 1 . . . . . . . . 2498 1 327 . 1 1 53 53 ASP HB2 H 1 2.8 . . 2 . . . . . . . . 2498 1 328 . 1 1 53 53 ASP HB3 H 1 2.93 . . 2 . . . . . . . . 2498 1 329 . 1 1 54 54 LEU H H 1 8.35 . . 1 . . . . . . . . 2498 1 330 . 1 1 54 54 LEU HA H 1 3.94 . . 1 . . . . . . . . 2498 1 331 . 1 1 54 54 LEU HB2 H 1 1.58 . . 1 . . . . . . . . 2498 1 332 . 1 1 54 54 LEU HB3 H 1 1.58 . . 1 . . . . . . . . 2498 1 333 . 1 1 54 54 LEU HG H 1 1.65 . . 1 . . . . . . . . 2498 1 334 . 1 1 54 54 LEU HD11 H 1 .84 . . 2 . . . . . . . . 2498 1 335 . 1 1 54 54 LEU HD12 H 1 .84 . . 2 . . . . . . . . 2498 1 336 . 1 1 54 54 LEU HD13 H 1 .84 . . 2 . . . . . . . . 2498 1 337 . 1 1 54 54 LEU HD21 H 1 .92 . . 2 . . . . . . . . 2498 1 338 . 1 1 54 54 LEU HD22 H 1 .92 . . 2 . . . . . . . . 2498 1 339 . 1 1 54 54 LEU HD23 H 1 .92 . . 2 . . . . . . . . 2498 1 340 . 1 1 55 55 ARG H H 1 7.98 . . 1 . . . . . . . . 2498 1 341 . 1 1 55 55 ARG HA H 1 3.95 . . 1 . . . . . . . . 2498 1 342 . 1 1 55 55 ARG HB2 H 1 1.6 . . 2 . . . . . . . . 2498 1 343 . 1 1 55 55 ARG HB3 H 1 1.68 . . 2 . . . . . . . . 2498 1 344 . 1 1 55 55 ARG HG2 H 1 1.81 . . 1 . . . . . . . . 2498 1 345 . 1 1 55 55 ARG HG3 H 1 1.81 . . 1 . . . . . . . . 2498 1 346 . 1 1 55 55 ARG HD2 H 1 3.18 . . 1 . . . . . . . . 2498 1 347 . 1 1 55 55 ARG HD3 H 1 3.18 . . 1 . . . . . . . . 2498 1 348 . 1 1 55 55 ARG HE H 1 7.31 . . 1 . . . . . . . . 2498 1 349 . 1 1 56 56 ARG H H 1 7.7 . . 1 . . . . . . . . 2498 1 350 . 1 1 56 56 ARG HA H 1 4.14 . . 1 . . . . . . . . 2498 1 351 . 1 1 56 56 ARG HB2 H 1 1.92 . . 2 . . . . . . . . 2498 1 352 . 1 1 56 56 ARG HB3 H 1 1.98 . . 2 . . . . . . . . 2498 1 353 . 1 1 56 56 ARG HG2 H 1 1.74 . . 1 . . . . . . . . 2498 1 354 . 1 1 56 56 ARG HG3 H 1 1.74 . . 1 . . . . . . . . 2498 1 355 . 1 1 56 56 ARG HD2 H 1 3.28 . . 1 . . . . . . . . 2498 1 356 . 1 1 56 56 ARG HD3 H 1 3.28 . . 1 . . . . . . . . 2498 1 357 . 1 1 56 56 ARG HE H 1 7.35 . . 1 . . . . . . . . 2498 1 358 . 1 1 57 57 LEU H H 1 7.8 . . 1 . . . . . . . . 2498 1 359 . 1 1 57 57 LEU HA H 1 4.1 . . 1 . . . . . . . . 2498 1 360 . 1 1 57 57 LEU HB2 H 1 1.5 . . 1 . . . . . . . . 2498 1 361 . 1 1 57 57 LEU HB3 H 1 1.5 . . 1 . . . . . . . . 2498 1 362 . 1 1 57 57 LEU HG H 1 1.72 . . 1 . . . . . . . . 2498 1 363 . 1 1 57 57 LEU HD11 H 1 .71 . . 2 . . . . . . . . 2498 1 364 . 1 1 57 57 LEU HD12 H 1 .71 . . 2 . . . . . . . . 2498 1 365 . 1 1 57 57 LEU HD13 H 1 .71 . . 2 . . . . . . . . 2498 1 366 . 1 1 57 57 LEU HD21 H 1 .74 . . 2 . . . . . . . . 2498 1 367 . 1 1 57 57 LEU HD22 H 1 .74 . . 2 . . . . . . . . 2498 1 368 . 1 1 57 57 LEU HD23 H 1 .74 . . 2 . . . . . . . . 2498 1 369 . 1 1 58 58 GLU H H 1 7.89 . . 1 . . . . . . . . 2498 1 370 . 1 1 58 58 GLU HA H 1 4.15 . . 1 . . . . . . . . 2498 1 371 . 1 1 58 58 GLU HB2 H 1 2.06 . . 1 . . . . . . . . 2498 1 372 . 1 1 58 58 GLU HB3 H 1 2.06 . . 1 . . . . . . . . 2498 1 373 . 1 1 58 58 GLU HG2 H 1 2.36 . . 2 . . . . . . . . 2498 1 374 . 1 1 58 58 GLU HG3 H 1 2.52 . . 2 . . . . . . . . 2498 1 375 . 1 1 59 59 MET H H 1 7.54 . . 1 . . . . . . . . 2498 1 376 . 1 1 59 59 MET HA H 1 4.16 . . 1 . . . . . . . . 2498 1 377 . 1 1 59 59 MET HB2 H 1 1.87 . . 2 . . . . . . . . 2498 1 378 . 1 1 59 59 MET HB3 H 1 1.99 . . 2 . . . . . . . . 2498 1 379 . 1 1 59 59 MET HG2 H 1 2.46 . . 1 . . . . . . . . 2498 1 380 . 1 1 59 59 MET HG3 H 1 2.46 . . 1 . . . . . . . . 2498 1 381 . 1 1 59 59 MET HE1 H 1 1.87 . . 1 . . . . . . . . 2498 1 382 . 1 1 59 59 MET HE2 H 1 1.87 . . 1 . . . . . . . . 2498 1 383 . 1 1 59 59 MET HE3 H 1 1.87 . . 1 . . . . . . . . 2498 1 384 . 1 1 60 60 TYR H H 1 7.82 . . 1 . . . . . . . . 2498 1 385 . 1 1 60 60 TYR HA H 1 4.44 . . 1 . . . . . . . . 2498 1 386 . 1 1 60 60 TYR HB2 H 1 2.88 . . 2 . . . . . . . . 2498 1 387 . 1 1 60 60 TYR HB3 H 1 3.43 . . 2 . . . . . . . . 2498 1 388 . 1 1 60 60 TYR HD1 H 1 7.26 . . 1 . . . . . . . . 2498 1 389 . 1 1 60 60 TYR HD2 H 1 7.26 . . 1 . . . . . . . . 2498 1 390 . 1 1 60 60 TYR HE1 H 1 6.69 . . 1 . . . . . . . . 2498 1 391 . 1 1 60 60 TYR HE2 H 1 6.69 . . 1 . . . . . . . . 2498 1 392 . 1 1 61 61 CYS H H 1 7.37 . . 1 . . . . . . . . 2498 1 393 . 1 1 61 61 CYS HA H 1 4.98 . . 1 . . . . . . . . 2498 1 394 . 1 1 61 61 CYS HB2 H 1 2.8 . . 2 . . . . . . . . 2498 1 395 . 1 1 61 61 CYS HB3 H 1 3.16 . . 2 . . . . . . . . 2498 1 396 . 1 1 62 62 ALA H H 1 8.18 . . 1 . . . . . . . . 2498 1 397 . 1 1 62 62 ALA HA H 1 4.38 . . 1 . . . . . . . . 2498 1 398 . 1 1 62 62 ALA HB1 H 1 1.19 . . 1 . . . . . . . . 2498 1 399 . 1 1 62 62 ALA HB2 H 1 1.19 . . 1 . . . . . . . . 2498 1 400 . 1 1 62 62 ALA HB3 H 1 1.19 . . 1 . . . . . . . . 2498 1 401 . 1 1 63 63 PRO HA H 1 4.33 . . 1 . . . . . . . . 2498 1 402 . 1 1 63 63 PRO HB2 H 1 2.22 . . 1 . . . . . . . . 2498 1 403 . 1 1 63 63 PRO HB3 H 1 2.22 . . 1 . . . . . . . . 2498 1 404 . 1 1 63 63 PRO HG2 H 1 1.86 . . 2 . . . . . . . . 2498 1 405 . 1 1 63 63 PRO HG3 H 1 1.95 . . 2 . . . . . . . . 2498 1 406 . 1 1 63 63 PRO HD2 H 1 3.58 . . 2 . . . . . . . . 2498 1 407 . 1 1 63 63 PRO HD3 H 1 3.75 . . 2 . . . . . . . . 2498 1 408 . 1 1 64 64 LEU H H 1 8.12 . . 1 . . . . . . . . 2498 1 409 . 1 1 64 64 LEU HA H 1 4.21 . . 1 . . . . . . . . 2498 1 410 . 1 1 64 64 LEU HB2 H 1 1.53 . . 1 . . . . . . . . 2498 1 411 . 1 1 64 64 LEU HB3 H 1 1.53 . . 1 . . . . . . . . 2498 1 412 . 1 1 64 64 LEU HG H 1 1.5 . . 1 . . . . . . . . 2498 1 413 . 1 1 64 64 LEU HD11 H 1 .82 . . 2 . . . . . . . . 2498 1 414 . 1 1 64 64 LEU HD12 H 1 .82 . . 2 . . . . . . . . 2498 1 415 . 1 1 64 64 LEU HD13 H 1 .82 . . 2 . . . . . . . . 2498 1 416 . 1 1 64 64 LEU HD21 H 1 .86 . . 2 . . . . . . . . 2498 1 417 . 1 1 64 64 LEU HD22 H 1 .86 . . 2 . . . . . . . . 2498 1 418 . 1 1 64 64 LEU HD23 H 1 .86 . . 2 . . . . . . . . 2498 1 419 . 1 1 65 65 LYS H H 1 8.13 . . 1 . . . . . . . . 2498 1 420 . 1 1 65 65 LYS HA H 1 4.56 . . 1 . . . . . . . . 2498 1 421 . 1 1 65 65 LYS HB2 H 1 1.64 . . 2 . . . . . . . . 2498 1 422 . 1 1 65 65 LYS HB3 H 1 1.76 . . 2 . . . . . . . . 2498 1 423 . 1 1 65 65 LYS HG2 H 1 1.4 . . 1 . . . . . . . . 2498 1 424 . 1 1 65 65 LYS HG3 H 1 1.4 . . 1 . . . . . . . . 2498 1 425 . 1 1 65 65 LYS HD2 H 1 1.65 . . 1 . . . . . . . . 2498 1 426 . 1 1 65 65 LYS HD3 H 1 1.65 . . 1 . . . . . . . . 2498 1 427 . 1 1 65 65 LYS HE2 H 1 2.97 . . 1 . . . . . . . . 2498 1 428 . 1 1 65 65 LYS HE3 H 1 2.97 . . 1 . . . . . . . . 2498 1 429 . 1 1 66 66 PRO HA H 1 4.35 . . 1 . . . . . . . . 2498 1 430 . 1 1 66 66 PRO HB2 H 1 2.21 . . 1 . . . . . . . . 2498 1 431 . 1 1 66 66 PRO HB3 H 1 2.21 . . 1 . . . . . . . . 2498 1 432 . 1 1 66 66 PRO HG2 H 1 1.85 . . 2 . . . . . . . . 2498 1 433 . 1 1 66 66 PRO HG3 H 1 1.93 . . 2 . . . . . . . . 2498 1 434 . 1 1 66 66 PRO HD2 H 1 3.58 . . 2 . . . . . . . . 2498 1 435 . 1 1 66 66 PRO HD3 H 1 3.75 . . 2 . . . . . . . . 2498 1 436 . 1 1 67 67 ALA H H 1 8.22 . . 1 . . . . . . . . 2498 1 437 . 1 1 67 67 ALA HA H 1 4.26 . . 1 . . . . . . . . 2498 1 438 . 1 1 67 67 ALA HB1 H 1 1.34 . . 1 . . . . . . . . 2498 1 439 . 1 1 67 67 ALA HB2 H 1 1.34 . . 1 . . . . . . . . 2498 1 440 . 1 1 67 67 ALA HB3 H 1 1.34 . . 1 . . . . . . . . 2498 1 441 . 1 1 68 68 LYS H H 1 8.1 . . 1 . . . . . . . . 2498 1 442 . 1 1 68 68 LYS HA H 1 4.3 . . 1 . . . . . . . . 2498 1 443 . 1 1 68 68 LYS HB2 H 1 1.72 . . 2 . . . . . . . . 2498 1 444 . 1 1 68 68 LYS HB3 H 1 1.8 . . 2 . . . . . . . . 2498 1 445 . 1 1 68 68 LYS HG2 H 1 1.39 . . 1 . . . . . . . . 2498 1 446 . 1 1 68 68 LYS HG3 H 1 1.39 . . 1 . . . . . . . . 2498 1 447 . 1 1 68 68 LYS HD2 H 1 1.64 . . 1 . . . . . . . . 2498 1 448 . 1 1 68 68 LYS HD3 H 1 1.64 . . 1 . . . . . . . . 2498 1 449 . 1 1 68 68 LYS HE2 H 1 2.97 . . 1 . . . . . . . . 2498 1 450 . 1 1 68 68 LYS HE3 H 1 2.97 . . 1 . . . . . . . . 2498 1 451 . 1 1 69 69 SER H H 1 8.14 . . 1 . . . . . . . . 2498 1 452 . 1 1 69 69 SER HA H 1 4.4 . . 1 . . . . . . . . 2498 1 453 . 1 1 69 69 SER HB2 H 1 3.83 . . 2 . . . . . . . . 2498 1 454 . 1 1 69 69 SER HB3 H 1 3.9 . . 2 . . . . . . . . 2498 1 455 . 1 1 70 70 ALA H H 1 8.12 . . 1 . . . . . . . . 2498 1 456 . 1 1 70 70 ALA HA H 1 4.33 . . 1 . . . . . . . . 2498 1 457 . 1 1 70 70 ALA HB1 H 1 1.27 . . 1 . . . . . . . . 2498 1 458 . 1 1 70 70 ALA HB2 H 1 1.27 . . 1 . . . . . . . . 2498 1 459 . 1 1 70 70 ALA HB3 H 1 1.27 . . 1 . . . . . . . . 2498 1 stop_ save_