data_34783 ####################### # Entry information # ####################### save_entry_information _Entry.Sf_category entry_information _Entry.Sf_framecode entry_information _Entry.ID 34783 _Entry.Title ; Macrophage inhibitory factor (MIF) in complex with small molecule PAV174 ; _Entry.Type macromolecule _Entry.Version_type original _Entry.Submission_date 2023-01-24 _Entry.Accession_date 2023-01-24 _Entry.Last_release_date 2023-06-16 _Entry.Original_release_date 2023-06-16 _Entry.Origination author _Entry.Format_name . _Entry.NMR_STAR_version 3.2.14.0 _Entry.NMR_STAR_dict_location . _Entry.Original_NMR_STAR_version 3.1 _Entry.Experimental_method NMR _Entry.Experimental_method_subtype 'SOLUTION NMR' _Entry.Source_data_format . _Entry.Source_data_format_version . _Entry.Generated_software_name . _Entry.Generated_software_version . _Entry.Generated_software_ID . _Entry.Generated_software_label . _Entry.Generated_date . _Entry.DOI . _Entry.UUID . _Entry.Related_coordinate_file_name . _Entry.Details . _Entry.BMRB_internal_directory_name . loop_ _Entry_author.Ordinal _Entry_author.Given_name _Entry_author.Family_name _Entry_author.First_initial _Entry_author.Middle_initials _Entry_author.Family_title _Entry_author.ORCID _Entry_author.Entry_ID 1 A. Mueller A. . . . 34783 2 F. Torres F. . . . 34783 3 R. Roland R. . . . 34783 4 C. Korth C. . . . 34783 stop_ loop_ _Struct_keywords.Keywords _Struct_keywords.Text _Struct_keywords.Entry_ID "Alzheimer's disease" . 34783 MIF . 34783 'PROTEIN BINDING' . 34783 herpes . 34783 oxMIF . 34783 stop_ loop_ _Data_set.Type _Data_set.Count _Data_set.Entry_ID assigned_chemical_shifts 1 34783 stop_ loop_ _Datum.Type _Datum.Count _Datum.Entry_ID '1H chemical shifts' 85 34783 stop_ loop_ _Release.Release_number _Release.Format_type _Release.Format_version _Release.Date _Release.Submission_date _Release.Type _Release.Author _Release.Detail _Release.Entry_ID 1 . . 2024-01-31 . original BMRB . 34783 stop_ loop_ _Related_entries.Database_name _Related_entries.Database_accession_code _Related_entries.Relationship _Related_entries.Entry_ID PDB 8CA0 'BMRB Entry Tracking System' 34783 stop_ save_ ############### # Citations # ############### save_citation_1 _Citation.Sf_category citations _Citation.Sf_framecode citation_1 _Citation.Entry_ID 34783 _Citation.ID 1 _Citation.Name . _Citation.Class 'entry citation' _Citation.CAS_abstract_code . _Citation.MEDLINE_UI_code . _Citation.PubMed_ID . _Citation.DOI . _Citation.Full_citation . _Citation.Title ; Oxidized MIF is a drug target at the molecular intersection between immune activation and tau cellular pathology ; _Citation.Status 'in preparation' _Citation.Type journal _Citation.Journal_abbrev . _Citation.Journal_name_full . _Citation.Journal_volume . _Citation.Journal_issue . _Citation.Journal_ASTM . _Citation.Journal_ISSN . _Citation.Journal_CSD 0353 _Citation.Book_title . _Citation.Book_chapter_title . _Citation.Book_volume . _Citation.Book_series . _Citation.Book_publisher . _Citation.Book_publisher_city . _Citation.Book_ISBN . _Citation.Conference_title . _Citation.Conference_site . _Citation.Conference_state_province . _Citation.Conference_country . _Citation.Conference_start_date . _Citation.Conference_end_date . _Citation.Conference_abstract_number . _Citation.Thesis_institution . _Citation.Thesis_institution_city . _Citation.Thesis_institution_country . _Citation.WWW_URL . _Citation.Page_first . _Citation.Page_last . _Citation.Year . _Citation.Details . loop_ _Citation_author.Ordinal _Citation_author.Given_name _Citation_author.Family_name _Citation_author.First_initial _Citation_author.Middle_initials _Citation_author.Family_title _Citation_author.ORCID _Citation_author.Entry_ID _Citation_author.Citation_ID 1 A. Mueller-Schiffmann A. . . . 34783 1 2 F. Torres F. . . . 34783 1 3 A. Kitaygorodskyy A. . . . 34783 1 4 A. Ramani A. . . . 34783 1 5 A. Alatza A. . . . 34783 1 6 S. Tschirner S. . . . 34783 1 7 I. Prikulis I. . . . 34783 1 8 S. Yu S. . . . 34783 1 9 D. Dey D. . . . 34783 1 10 S. Mallesh S. . . . 34783 1 11 D. Prasad D. . . . 34783 1 12 D. Solas D. . . . 34783 1 13 V. Bader V. . . . 34783 1 14 A. Rozemuller A. . . . 34783 1 15 S. Wray S. . . . 34783 1 16 J. Gopalakrishnan J. . . . 34783 1 17 R. Riek R. . . . 34783 1 18 V. Lingappa V. R. . . 34783 1 19 C. Korth C. . . . 34783 1 stop_ save_ ############################################# # Molecular system (assembly) description # ############################################# save_assembly _Assembly.Sf_category assembly _Assembly.Sf_framecode assembly _Assembly.Entry_ID 34783 _Assembly.ID 1 _Assembly.Name 'Macrophage migration inhibitory factor (E.C.5.3.2.1,5.3.3.12)' _Assembly.BMRB_code . _Assembly.Number_of_components . _Assembly.Organic_ligands . _Assembly.Metal_ions . _Assembly.Non_standard_bonds . _Assembly.Ambiguous_conformational_states . _Assembly.Ambiguous_chem_comp_sites . _Assembly.Molecules_in_chemical_exchange . _Assembly.Paramagnetic no _Assembly.Thiol_state . _Assembly.Molecular_mass . _Assembly.Enzyme_commission_number . _Assembly.Details . _Assembly.DB_query_date . _Assembly.DB_query_revised_last_date . loop_ _Entity_assembly.ID _Entity_assembly.Entity_assembly_name _Entity_assembly.Entity_ID _Entity_assembly.Entity_label _Entity_assembly.Asym_ID _Entity_assembly.PDB_chain_ID _Entity_assembly.Experimental_data_reported _Entity_assembly.Physical_state _Entity_assembly.Conformational_isomer _Entity_assembly.Chemical_exchange_state _Entity_assembly.Magnetic_equivalence_group_code _Entity_assembly.Role _Entity_assembly.Details _Entity_assembly.Entry_ID _Entity_assembly.Assembly_ID 1 unit_1 1 $entity_1 A A yes . . . . . . 34783 1 2 unit_2 1 $entity_1 B B yes . . . . . . 34783 1 3 unit_3 1 $entity_1 C C yes . . . . . . 34783 1 4 unit_4 2 $entity_2 D A no . . . . . . 34783 1 stop_ save_ #################################### # Biological polymers and ligands # #################################### save_entity_1 _Entity.Sf_category entity _Entity.Sf_framecode entity_1 _Entity.Entry_ID 34783 _Entity.ID 1 _Entity.BMRB_code . _Entity.Name entity_1 _Entity.Type polymer _Entity.Polymer_common_type . _Entity.Polymer_type polypeptide(L) _Entity.Polymer_type_details . _Entity.Polymer_strand_ID A,B,C _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code ; PMFIVNTNVPRASVPDGFLS ELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCS LHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYD MNAANVGWNNSTFA ; _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states . _Entity.Ambiguous_chem_comp_sites . _Entity.Nstd_monomer no _Entity.Nstd_chirality . _Entity.Nstd_linkage no _Entity.Nonpolymer_comp_ID . _Entity.Nonpolymer_comp_label . _Entity.Number_of_monomers 114 _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic no _Entity.Thiol_state . _Entity.Src_method man _Entity.Parent_entity_ID 1 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number 5.3.2.1,5.3.3.12 _Entity.Calc_isoelectric_point . _Entity.Formula_weight 12355.056 _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date . loop_ _Entity_common_name.Name _Entity_common_name.Type _Entity_common_name.Entry_ID _Entity_common_name.Entity_ID GIF common 34783 1 'Glycosylation-inhibiting factor' common 34783 1 'L-dopachrome isomerase' common 34783 1 'L-dopachrome tautomerase' common 34783 1 MIF common 34783 1 'Phenylpyruvate tautomerase' common 34783 1 stop_ loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 . PRO . 34783 1 2 . MET . 34783 1 3 . PHE . 34783 1 4 . ILE . 34783 1 5 . VAL . 34783 1 6 . ASN . 34783 1 7 . THR . 34783 1 8 . ASN . 34783 1 9 . VAL . 34783 1 10 . PRO . 34783 1 11 . ARG . 34783 1 12 . ALA . 34783 1 13 . SER . 34783 1 14 . VAL . 34783 1 15 . PRO . 34783 1 16 . ASP . 34783 1 17 . GLY . 34783 1 18 . PHE . 34783 1 19 . LEU . 34783 1 20 . SER . 34783 1 21 . GLU . 34783 1 22 . LEU . 34783 1 23 . THR . 34783 1 24 . GLN . 34783 1 25 . GLN . 34783 1 26 . LEU . 34783 1 27 . ALA . 34783 1 28 . GLN . 34783 1 29 . ALA . 34783 1 30 . THR . 34783 1 31 . GLY . 34783 1 32 . LYS . 34783 1 33 . PRO . 34783 1 34 . PRO . 34783 1 35 . GLN . 34783 1 36 . TYR . 34783 1 37 . ILE . 34783 1 38 . ALA . 34783 1 39 . VAL . 34783 1 40 . HIS . 34783 1 41 . VAL . 34783 1 42 . VAL . 34783 1 43 . PRO . 34783 1 44 . ASP . 34783 1 45 . GLN . 34783 1 46 . LEU . 34783 1 47 . MET . 34783 1 48 . ALA . 34783 1 49 . PHE . 34783 1 50 . GLY . 34783 1 51 . GLY . 34783 1 52 . SER . 34783 1 53 . SER . 34783 1 54 . GLU . 34783 1 55 . PRO . 34783 1 56 . CYS . 34783 1 57 . ALA . 34783 1 58 . LEU . 34783 1 59 . CYS . 34783 1 60 . SER . 34783 1 61 . LEU . 34783 1 62 . HIS . 34783 1 63 . SER . 34783 1 64 . ILE . 34783 1 65 . GLY . 34783 1 66 . LYS . 34783 1 67 . ILE . 34783 1 68 . GLY . 34783 1 69 . GLY . 34783 1 70 . ALA . 34783 1 71 . GLN . 34783 1 72 . ASN . 34783 1 73 . ARG . 34783 1 74 . SER . 34783 1 75 . TYR . 34783 1 76 . SER . 34783 1 77 . LYS . 34783 1 78 . LEU . 34783 1 79 . LEU . 34783 1 80 . CYS . 34783 1 81 . GLY . 34783 1 82 . LEU . 34783 1 83 . LEU . 34783 1 84 . ALA . 34783 1 85 . GLU . 34783 1 86 . ARG . 34783 1 87 . LEU . 34783 1 88 . ARG . 34783 1 89 . ILE . 34783 1 90 . SER . 34783 1 91 . PRO . 34783 1 92 . ASP . 34783 1 93 . ARG . 34783 1 94 . VAL . 34783 1 95 . TYR . 34783 1 96 . ILE . 34783 1 97 . ASN . 34783 1 98 . TYR . 34783 1 99 . TYR . 34783 1 100 . ASP . 34783 1 101 . MET . 34783 1 102 . ASN . 34783 1 103 . ALA . 34783 1 104 . ALA . 34783 1 105 . ASN . 34783 1 106 . VAL . 34783 1 107 . GLY . 34783 1 108 . TRP . 34783 1 109 . ASN . 34783 1 110 . ASN . 34783 1 111 . SER . 34783 1 112 . THR . 34783 1 113 . PHE . 34783 1 114 . ALA . 34783 1 stop_ loop_ _Entity_poly_seq.Hetero _Entity_poly_seq.Mon_ID _Entity_poly_seq.Num _Entity_poly_seq.Comp_index_ID _Entity_poly_seq.Entry_ID _Entity_poly_seq.Entity_ID . PRO 1 1 34783 1 . MET 2 2 34783 1 . PHE 3 3 34783 1 . ILE 4 4 34783 1 . VAL 5 5 34783 1 . ASN 6 6 34783 1 . THR 7 7 34783 1 . ASN 8 8 34783 1 . VAL 9 9 34783 1 . PRO 10 10 34783 1 . ARG 11 11 34783 1 . ALA 12 12 34783 1 . SER 13 13 34783 1 . VAL 14 14 34783 1 . PRO 15 15 34783 1 . ASP 16 16 34783 1 . GLY 17 17 34783 1 . PHE 18 18 34783 1 . LEU 19 19 34783 1 . SER 20 20 34783 1 . GLU 21 21 34783 1 . LEU 22 22 34783 1 . THR 23 23 34783 1 . GLN 24 24 34783 1 . GLN 25 25 34783 1 . LEU 26 26 34783 1 . ALA 27 27 34783 1 . GLN 28 28 34783 1 . ALA 29 29 34783 1 . THR 30 30 34783 1 . GLY 31 31 34783 1 . LYS 32 32 34783 1 . PRO 33 33 34783 1 . PRO 34 34 34783 1 . GLN 35 35 34783 1 . TYR 36 36 34783 1 . ILE 37 37 34783 1 . ALA 38 38 34783 1 . VAL 39 39 34783 1 . HIS 40 40 34783 1 . VAL 41 41 34783 1 . VAL 42 42 34783 1 . PRO 43 43 34783 1 . ASP 44 44 34783 1 . GLN 45 45 34783 1 . LEU 46 46 34783 1 . MET 47 47 34783 1 . ALA 48 48 34783 1 . PHE 49 49 34783 1 . GLY 50 50 34783 1 . GLY 51 51 34783 1 . SER 52 52 34783 1 . SER 53 53 34783 1 . GLU 54 54 34783 1 . PRO 55 55 34783 1 . CYS 56 56 34783 1 . ALA 57 57 34783 1 . LEU 58 58 34783 1 . CYS 59 59 34783 1 . SER 60 60 34783 1 . LEU 61 61 34783 1 . HIS 62 62 34783 1 . SER 63 63 34783 1 . ILE 64 64 34783 1 . GLY 65 65 34783 1 . LYS 66 66 34783 1 . ILE 67 67 34783 1 . GLY 68 68 34783 1 . GLY 69 69 34783 1 . ALA 70 70 34783 1 . GLN 71 71 34783 1 . ASN 72 72 34783 1 . ARG 73 73 34783 1 . SER 74 74 34783 1 . TYR 75 75 34783 1 . SER 76 76 34783 1 . LYS 77 77 34783 1 . LEU 78 78 34783 1 . LEU 79 79 34783 1 . CYS 80 80 34783 1 . GLY 81 81 34783 1 . LEU 82 82 34783 1 . LEU 83 83 34783 1 . ALA 84 84 34783 1 . GLU 85 85 34783 1 . ARG 86 86 34783 1 . LEU 87 87 34783 1 . ARG 88 88 34783 1 . ILE 89 89 34783 1 . SER 90 90 34783 1 . PRO 91 91 34783 1 . ASP 92 92 34783 1 . ARG 93 93 34783 1 . VAL 94 94 34783 1 . TYR 95 95 34783 1 . ILE 96 96 34783 1 . ASN 97 97 34783 1 . TYR 98 98 34783 1 . TYR 99 99 34783 1 . ASP 100 100 34783 1 . MET 101 101 34783 1 . ASN 102 102 34783 1 . ALA 103 103 34783 1 . ALA 104 104 34783 1 . ASN 105 105 34783 1 . VAL 106 106 34783 1 . GLY 107 107 34783 1 . TRP 108 108 34783 1 . ASN 109 109 34783 1 . ASN 110 110 34783 1 . SER 111 111 34783 1 . THR 112 112 34783 1 . PHE 113 113 34783 1 . ALA 114 114 34783 1 stop_ save_ save_entity_2 _Entity.Sf_category entity _Entity.Sf_framecode entity_2 _Entity.Entry_ID 34783 _Entity.ID 2 _Entity.BMRB_code . _Entity.Name entity_2 _Entity.Type non-polymer _Entity.Polymer_common_type . _Entity.Polymer_type . _Entity.Polymer_type_details . _Entity.Polymer_strand_ID . _Entity.Polymer_seq_one_letter_code_can . _Entity.Polymer_seq_one_letter_code . _Entity.Target_identifier . _Entity.Polymer_author_defined_seq . _Entity.Polymer_author_seq_details . _Entity.Ambiguous_conformational_states . _Entity.Ambiguous_chem_comp_sites . _Entity.Nstd_monomer . _Entity.Nstd_chirality . _Entity.Nstd_linkage . _Entity.Nonpolymer_comp_ID VIU _Entity.Nonpolymer_comp_label $chem_comp_VIU _Entity.Number_of_monomers . _Entity.Number_of_nonpolymer_components . _Entity.Paramagnetic . _Entity.Thiol_state . _Entity.Src_method syn _Entity.Parent_entity_ID 2 _Entity.Fragment . _Entity.Mutation . _Entity.EC_number . _Entity.Calc_isoelectric_point . _Entity.Formula_weight 379.561 _Entity.Formula_weight_exptl . _Entity.Formula_weight_exptl_meth . _Entity.Details . _Entity.DB_query_date . _Entity.DB_query_revised_last_date . loop_ _Entity_comp_index.ID _Entity_comp_index.Auth_seq_ID _Entity_comp_index.Comp_ID _Entity_comp_index.Comp_label _Entity_comp_index.Entry_ID _Entity_comp_index.Entity_ID 1 201 VIU . 34783 2 stop_ save_ #################### # Natural source # #################### save_natural_source _Entity_natural_src_list.Sf_category natural_source _Entity_natural_src_list.Sf_framecode natural_source _Entity_natural_src_list.Entry_ID 34783 _Entity_natural_src_list.ID 1 loop_ _Entity_natural_src.ID _Entity_natural_src.Entity_ID _Entity_natural_src.Entity_label _Entity_natural_src.Entity_chimera_segment_ID _Entity_natural_src.NCBI_taxonomy_ID _Entity_natural_src.Type _Entity_natural_src.Common _Entity_natural_src.Organism_name_scientific _Entity_natural_src.Organism_name_common _Entity_natural_src.Organism_acronym _Entity_natural_src.ICTVdb_decimal_code _Entity_natural_src.Superkingdom _Entity_natural_src.Kingdom _Entity_natural_src.Genus _Entity_natural_src.Species _Entity_natural_src.Strain _Entity_natural_src.Variant _Entity_natural_src.Organ _Entity_natural_src.Tissue _Entity_natural_src.Tissue_fraction _Entity_natural_src.Cell_line _Entity_natural_src.Cell_type _Entity_natural_src.ATCC_number _Entity_natural_src.Organelle _Entity_natural_src.Secretion _Entity_natural_src.Plasmid _Entity_natural_src.Gene_mnemonic _Entity_natural_src.Details _Entity_natural_src.Entry_ID _Entity_natural_src.Entity_natural_src_list_ID 1 1 $entity_1 . 9606 organism . 'Homo sapiens' Human . . Eukaryota Metazoa Homo sapiens . . . . . . . . . . . 'MIF, GLIF, MMIF' . 34783 1 stop_ save_ ######################### # Experimental source # ######################### save_experimental_source _Entity_experimental_src_list.Sf_category experimental_source _Entity_experimental_src_list.Sf_framecode experimental_source _Entity_experimental_src_list.Entry_ID 34783 _Entity_experimental_src_list.ID 1 loop_ _Entity_experimental_src.ID _Entity_experimental_src.Entity_ID _Entity_experimental_src.Entity_label _Entity_experimental_src.Entity_chimera_segment_ID _Entity_experimental_src.Production_method _Entity_experimental_src.Host_org_scientific_name _Entity_experimental_src.Host_org_name_common _Entity_experimental_src.Host_org_details _Entity_experimental_src.Host_org_NCBI_taxonomy_ID _Entity_experimental_src.Host_org_genus _Entity_experimental_src.Host_org_species _Entity_experimental_src.Host_org_strain _Entity_experimental_src.Host_org_variant _Entity_experimental_src.Host_org_ATCC_number _Entity_experimental_src.Vector_type _Entity_experimental_src.PDBview_host_org_vector_name _Entity_experimental_src.PDBview_plasmid_name _Entity_experimental_src.Vector_name _Entity_experimental_src.Vector_details _Entity_experimental_src.Vendor_name _Entity_experimental_src.Details _Entity_experimental_src.Entry_ID _Entity_experimental_src.Entity_experimental_src_list_ID 1 1 $entity_1 . 'recombinant technology' 'Escherichia coli' . . 562 Escherichia coli . . . . . . . . . . 34783 1 stop_ save_ ################################# # Polymer residues and ligands # ################################# save_chem_comp_VIU _Chem_comp.Sf_category chem_comp _Chem_comp.Sf_framecode chem_comp_VIU _Chem_comp.Entry_ID 34783 _Chem_comp.ID VIU _Chem_comp.Provenance . _Chem_comp.Name 1-ethyl-9-methyl-3,7-dipyrrolidin-1-yl-phenothiazine _Chem_comp.Type non-polymer _Chem_comp.BMRB_code . _Chem_comp.PDB_code VIU _Chem_comp.Ambiguous_flag . _Chem_comp.Initial_date . _Chem_comp.Modified_date . _Chem_comp.Release_status . _Chem_comp.Replaced_by . _Chem_comp.Replaces . _Chem_comp.One_letter_code . _Chem_comp.Three_letter_code . _Chem_comp.Number_atoms_all . _Chem_comp.Number_atoms_nh . _Chem_comp.Atom_nomenclature_source . _Chem_comp.PubChem_code . _Chem_comp.Subcomponent_list . _Chem_comp.InChI_code . _Chem_comp.Mon_nstd_flag no _Chem_comp.Mon_nstd_class . _Chem_comp.Mon_nstd_details . _Chem_comp.Mon_nstd_parent . _Chem_comp.Mon_nstd_parent_comp_ID . _Chem_comp.Std_deriv_one_letter_code . _Chem_comp.Std_deriv_three_letter_code . _Chem_comp.Std_deriv_BMRB_code . _Chem_comp.Std_deriv_PDB_code . _Chem_comp.Std_deriv_chem_comp_name . _Chem_comp.Synonyms . _Chem_comp.Formal_charge . _Chem_comp.Paramagnetic . _Chem_comp.Aromatic . _Chem_comp.Formula 'C23 H29 N3 S' _Chem_comp.Formula_weight 379.561 _Chem_comp.Formula_mono_iso_wt_nat . _Chem_comp.Formula_mono_iso_wt_13C . _Chem_comp.Formula_mono_iso_wt_15N . _Chem_comp.Formula_mono_iso_wt_13C_15N . _Chem_comp.Image_file_name . _Chem_comp.Image_file_format . _Chem_comp.Topo_file_name . _Chem_comp.Topo_file_format . _Chem_comp.Struct_file_name . _Chem_comp.Struct_file_format . _Chem_comp.Stereochem_param_file_name . _Chem_comp.Stereochem_param_file_format . _Chem_comp.Model_details . _Chem_comp.Model_erf . _Chem_comp.Model_source . _Chem_comp.Model_coordinates_details . _Chem_comp.Model_coordinates_missing_flag . _Chem_comp.Ideal_coordinates_details . _Chem_comp.Ideal_coordinates_missing_flag . _Chem_comp.Model_coordinates_db_code . _Chem_comp.Processing_site . _Chem_comp.Vendor . _Chem_comp.Vendor_product_code . _Chem_comp.Details . _Chem_comp.DB_query_date . _Chem_comp.DB_last_query_revised_last_date . save_ ##################################### # Sample contents and methodology # ##################################### ######################## # Sample description # ######################## save_sample_1 _Sample.Sf_category sample _Sample.Sf_framecode sample_1 _Sample.Entry_ID 34783 _Sample.ID 1 _Sample.Name . _Sample.Type solution _Sample.Sub_type . _Sample.Details '1.0 mM [U-13C; U-15N] MIF, 1.0 mM PAV, 100% D2O' _Sample.Aggregate_sample_number . _Sample.Solvent_system '100% D2O' _Sample.Preparation_date . _Sample.Preparation_expiration_date . _Sample.Polycrystallization_protocol . _Sample.Single_crystal_protocol . _Sample.Crystal_grow_apparatus . _Sample.Crystal_grow_atmosphere . _Sample.Crystal_grow_details . _Sample.Crystal_grow_method . _Sample.Crystal_grow_method_cit_ID . _Sample.Crystal_grow_pH . _Sample.Crystal_grow_pH_range . _Sample.Crystal_grow_pressure . _Sample.Crystal_grow_pressure_esd . _Sample.Crystal_grow_seeding . _Sample.Crystal_grow_seeding_cit_ID . _Sample.Crystal_grow_temp . _Sample.Crystal_grow_temp_details . _Sample.Crystal_grow_temp_esd . _Sample.Crystal_grow_time . _Sample.Oriented_sample_prep_protocol . _Sample.Lyophilization_cryo_protectant . _Sample.Storage_protocol . loop_ _Sample_component.ID _Sample_component.Mol_common_name _Sample_component.Isotopic_labeling _Sample_component.Assembly_ID _Sample_component.Assembly_label _Sample_component.Entity_ID _Sample_component.Entity_label _Sample_component.Product_ID _Sample_component.Type _Sample_component.Concentration_val _Sample_component.Concentration_val_min _Sample_component.Concentration_val_max _Sample_component.Concentration_val_units _Sample_component.Concentration_val_err _Sample_component.Vendor _Sample_component.Vendor_product_name _Sample_component.Vendor_product_code _Sample_component.Entry_ID _Sample_component.Sample_ID 1 MIF '[U-13C; U-15N]' . . 1 $entity_1 . . 1.0 . . mM . . . . 34783 1 2 PAV 'natural abundance' . . . . . . 1.0 . . mM . . . . 34783 1 stop_ save_ ####################### # Sample conditions # ####################### save_sample_conditions_1 _Sample_condition_list.Sf_category sample_conditions _Sample_condition_list.Sf_framecode sample_conditions_1 _Sample_condition_list.Entry_ID 34783 _Sample_condition_list.ID 1 _Sample_condition_list.Name . _Sample_condition_list.Details . loop_ _Sample_condition_variable.Type _Sample_condition_variable.Val _Sample_condition_variable.Val_err _Sample_condition_variable.Val_units _Sample_condition_variable.Entry_ID _Sample_condition_variable.Sample_condition_list_ID 'ionic strength' 20 . mM 34783 1 pH 7.2 . pH 34783 1 pressure 1 . Pa 34783 1 temperature 298 . K 34783 1 stop_ save_ ############################ # Computer software used # ############################ save_software_1 _Software.Sf_category software _Software.Sf_framecode software_1 _Software.Entry_ID 34783 _Software.ID 1 _Software.Type . _Software.Name 'CcpNmr Analysis' _Software.Version . _Software.DOI . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID CCPN . . 34783 1 stop_ loop_ _Task.Task _Task.Software_module _Task.Entry_ID _Task.Software_ID 'chemical shift assignment' . 34783 1 stop_ save_ save_software_2 _Software.Sf_category software _Software.Sf_framecode software_2 _Software.Entry_ID 34783 _Software.ID 2 _Software.Type . _Software.Name CYANA _Software.Version . _Software.DOI . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID 'Guntert, Mumenthaler and Wuthrich' . . 34783 2 stop_ loop_ _Task.Task _Task.Software_module _Task.Entry_ID _Task.Software_ID 'structure calculation' . 34783 2 stop_ save_ save_software_3 _Software.Sf_category software _Software.Sf_framecode software_3 _Software.Entry_ID 34783 _Software.ID 3 _Software.Type . _Software.Name HADDOCK _Software.Version . _Software.DOI . _Software.Details . loop_ _Vendor.Name _Vendor.Address _Vendor.Electronic_address _Vendor.Entry_ID _Vendor.Software_ID 'Alexandre Bonvin, University Utrecht' . . 34783 3 stop_ loop_ _Task.Task _Task.Software_module _Task.Entry_ID _Task.Software_ID refinement . 34783 3 stop_ save_ ######################### # Experimental detail # ######################### ################################## # NMR Spectrometer definitions # ################################## save_NMR_spectrometer_1 _NMR_spectrometer.Sf_category NMR_spectrometer _NMR_spectrometer.Sf_framecode NMR_spectrometer_1 _NMR_spectrometer.Entry_ID 34783 _NMR_spectrometer.ID 1 _NMR_spectrometer.Name . _NMR_spectrometer.Details . _NMR_spectrometer.Manufacturer Bruker _NMR_spectrometer.Model 'AVANCE NEO' _NMR_spectrometer.Serial_number . _NMR_spectrometer.Field_strength 700 save_ save_NMR_spectrometer_list _NMR_spectrometer_list.Sf_category NMR_spectrometer_list _NMR_spectrometer_list.Sf_framecode NMR_spectrometer_list _NMR_spectrometer_list.Entry_ID 34783 _NMR_spectrometer_list.ID 1 _NMR_spectrometer_list.Name . loop_ _NMR_spectrometer_view.ID _NMR_spectrometer_view.Name _NMR_spectrometer_view.Manufacturer _NMR_spectrometer_view.Model _NMR_spectrometer_view.Serial_number _NMR_spectrometer_view.Field_strength _NMR_spectrometer_view.Details _NMR_spectrometer_view.Citation_ID _NMR_spectrometer_view.Citation_label _NMR_spectrometer_view.Entry_ID _NMR_spectrometer_view.NMR_spectrometer_list_ID 1 NMR_spectrometer_1 Bruker 'AVANCE NEO' . 700 . . . 34783 1 stop_ save_ ############################# # NMR applied experiments # ############################# save_experiment_list _Experiment_list.Sf_category experiment_list _Experiment_list.Sf_framecode experiment_list _Experiment_list.Entry_ID 34783 _Experiment_list.ID 1 _Experiment_list.Details . loop_ _Experiment.ID _Experiment.Name _Experiment.Raw_data_flag _Experiment.NUS_flag _Experiment.Interleaved_flag _Experiment.NMR_spec_expt_ID _Experiment.NMR_spec_expt_label _Experiment.MS_expt_ID _Experiment.MS_expt_label _Experiment.SAXS_expt_ID _Experiment.SAXS_expt_label _Experiment.FRET_expt_ID _Experiment.FRET_expt_label _Experiment.EMR_expt_ID _Experiment.EMR_expt_label _Experiment.Sample_ID _Experiment.Sample_label _Experiment.Sample_state _Experiment.Sample_volume _Experiment.Sample_volume_units _Experiment.Sample_condition_list_ID _Experiment.Sample_condition_list_label _Experiment.Sample_spinning_rate _Experiment.Sample_angle _Experiment.NMR_tube_type _Experiment.NMR_spectrometer_ID _Experiment.NMR_spectrometer_label _Experiment.NMR_spectrometer_probe_ID _Experiment.NMR_spectrometer_probe_label _Experiment.NMR_spectral_processing_ID _Experiment.NMR_spectral_processing_label _Experiment.Mass_spectrometer_ID _Experiment.Mass_spectrometer_label _Experiment.Xray_instrument_ID _Experiment.Xray_instrument_label _Experiment.Fluorescence_instrument_ID _Experiment.Fluorescence_instrument_label _Experiment.EMR_instrument_ID _Experiment.EMR_instrument_label _Experiment.Chromatographic_system_ID _Experiment.Chromatographic_system_label _Experiment.Chromatographic_column_ID _Experiment.Chromatographic_column_label _Experiment.Details _Experiment.Entry_ID _Experiment.Experiment_list_ID 1 '2D 1H-1H NOESY' no . . . . . . . . . . . . 1 $sample_1 isotropic . . 1 $sample_conditions_1 . . . 1 $NMR_spectrometer_1 . . . . . . . . . . . . . . . . . 34783 1 stop_ save_ #################### # NMR parameters # #################### ############################## # Assigned chemical shifts # ############################## ################################ # Chemical shift referencing # ################################ save_chem_shift_reference_1 _Chem_shift_reference.Sf_category chem_shift_reference _Chem_shift_reference.Sf_framecode chem_shift_reference_1 _Chem_shift_reference.Entry_ID 34783 _Chem_shift_reference.ID 1 _Chem_shift_reference.Name . _Chem_shift_reference.Details . loop_ _Chem_shift_ref.Atom_type _Chem_shift_ref.Atom_isotope_number _Chem_shift_ref.Mol_common_name _Chem_shift_ref.Atom_group _Chem_shift_ref.Concentration_val _Chem_shift_ref.Concentration_units _Chem_shift_ref.Solvent _Chem_shift_ref.Rank _Chem_shift_ref.Chem_shift_units _Chem_shift_ref.Chem_shift_val _Chem_shift_ref.Ref_method _Chem_shift_ref.Ref_type _Chem_shift_ref.Indirect_shift_ratio _Chem_shift_ref.External_ref_loc _Chem_shift_ref.External_ref_sample_geometry _Chem_shift_ref.External_ref_axis _Chem_shift_ref.Ref_correction_type _Chem_shift_ref.Correction_val _Chem_shift_ref.Entry_ID _Chem_shift_ref.Chem_shift_reference_ID H 1 water protons . . . . ppm 4.7 na direct 1.0 . . . . . 34783 1 stop_ save_ ################################### # Assigned chemical shift lists # ################################### ################################################################### # Chemical Shift Ambiguity Index Value Definitions # # # # The values other than 1 are used for those atoms with different # # chemical shifts that cannot be assigned to stereospecific atoms # # or to specific residues or chains. # # # # Index Value Definition # # # # 1 Unique (including isolated methyl protons, # # geminal atoms, and geminal methyl # # groups with identical chemical shifts) # # (e.g. ILE HD11, HD12, HD13 protons) # # 2 Ambiguity of geminal atoms or geminal methyl # # proton groups (e.g. ASP HB2 and HB3 # # protons, LEU CD1 and CD2 carbons, or # # LEU HD11, HD12, HD13 and HD21, HD22, # # HD23 methyl protons) # # 3 Aromatic atoms on opposite sides of # # symmetrical rings (e.g. TYR HE1 and HE2 # # protons) # # 4 Intraresidue ambiguities (e.g. LYS HG and # # HD protons or TRP HZ2 and HZ3 protons) # # 5 Interresidue ambiguities (LYS 12 vs. LYS 27) # # 6 Intermolecular ambiguities (e.g. ASP 31 CA # # in monomer 1 and ASP 31 CA in monomer 2 # # of an asymmetrical homodimer, duplex # # DNA assignments, or other assignments # # that may apply to atoms in one or more # # molecule in the molecular assembly) # # 9 Ambiguous, specific ambiguity not defined # # # ################################################################### save_assigned_chemical_shifts_1 _Assigned_chem_shift_list.Sf_category assigned_chemical_shifts _Assigned_chem_shift_list.Sf_framecode assigned_chemical_shifts_1 _Assigned_chem_shift_list.Entry_ID 34783 _Assigned_chem_shift_list.ID 1 _Assigned_chem_shift_list.Name . _Assigned_chem_shift_list.Sample_condition_list_ID 1 _Assigned_chem_shift_list.Sample_condition_list_label $sample_conditions_1 _Assigned_chem_shift_list.Chem_shift_reference_ID 1 _Assigned_chem_shift_list.Chem_shift_reference_label $chem_shift_reference_1 _Assigned_chem_shift_list.Chem_shift_1H_err . _Assigned_chem_shift_list.Chem_shift_13C_err . _Assigned_chem_shift_list.Chem_shift_15N_err . _Assigned_chem_shift_list.Chem_shift_31P_err . _Assigned_chem_shift_list.Chem_shift_2H_err . _Assigned_chem_shift_list.Chem_shift_19F_err . _Assigned_chem_shift_list.Error_derivation_method . _Assigned_chem_shift_list.Details . _Assigned_chem_shift_list.Text_data_format . _Assigned_chem_shift_list.Text_data . loop_ _Chem_shift_experiment.Experiment_ID _Chem_shift_experiment.Experiment_name _Chem_shift_experiment.Sample_ID _Chem_shift_experiment.Sample_label _Chem_shift_experiment.Sample_state _Chem_shift_experiment.Entry_ID _Chem_shift_experiment.Assigned_chem_shift_list_ID 1 '2D 1H-1H NOESY' . . . 34783 1 stop_ loop_ _Atom_chem_shift.ID _Atom_chem_shift.Assembly_atom_ID _Atom_chem_shift.Entity_assembly_ID _Atom_chem_shift.Entity_assembly_asym_ID _Atom_chem_shift.Entity_ID _Atom_chem_shift.Comp_index_ID _Atom_chem_shift.Seq_ID _Atom_chem_shift.Comp_ID _Atom_chem_shift.Atom_ID _Atom_chem_shift.Atom_type _Atom_chem_shift.Atom_isotope_number _Atom_chem_shift.Val _Atom_chem_shift.Val_err _Atom_chem_shift.Assign_fig_of_merit _Atom_chem_shift.Ambiguity_code _Atom_chem_shift.Ambiguity_set_ID _Atom_chem_shift.Occupancy _Atom_chem_shift.Resonance_ID _Atom_chem_shift.Auth_entity_assembly_ID _Atom_chem_shift.Auth_asym_ID _Atom_chem_shift.Auth_seq_ID _Atom_chem_shift.Auth_comp_ID _Atom_chem_shift.Auth_atom_ID _Atom_chem_shift.Details _Atom_chem_shift.Entry_ID _Atom_chem_shift.Assigned_chem_shift_list_ID 1 . 1 . 1 36 36 TYR HD1 H 1 6.228 0.020 . 1 . . . . A 36 TYR HD1 . 34783 1 2 . 1 . 1 36 36 TYR HD2 H 1 6.228 0.020 . 1 . . . . A 36 TYR HD2 . 34783 1 3 . 1 . 1 36 36 TYR HE1 H 1 6.976 0.020 . 1 . . . . A 36 TYR HE1 . 34783 1 4 . 1 . 1 36 36 TYR HE2 H 1 6.976 0.020 . 1 . . . . A 36 TYR HE2 . 34783 1 5 . 1 . 1 49 49 PHE HE1 H 1 7.222 0.020 . 1 . . . . A 49 PHE HE1 . 34783 1 6 . 1 . 1 49 49 PHE HE2 H 1 7.222 0.020 . 1 . . . . A 49 PHE HE2 . 34783 1 7 . 1 . 1 106 106 VAL HG11 H 1 0.808 0.020 . 2 . . . . A 106 VAL HG11 . 34783 1 8 . 1 . 1 106 106 VAL HG12 H 1 0.808 0.020 . 2 . . . . A 106 VAL HG12 . 34783 1 9 . 1 . 1 106 106 VAL HG13 H 1 0.808 0.020 . 2 . . . . A 106 VAL HG13 . 34783 1 10 . 1 . 1 106 106 VAL HG21 H 1 0.467 0.020 . 2 . . . . A 106 VAL HG21 . 34783 1 11 . 1 . 1 106 106 VAL HG22 H 1 0.467 0.020 . 2 . . . . A 106 VAL HG22 . 34783 1 12 . 1 . 1 106 106 VAL HG23 H 1 0.467 0.020 . 2 . . . . A 106 VAL HG23 . 34783 1 13 . 1 . 1 108 108 TRP HD1 H 1 7.077 0.020 . 1 . . . . A 108 TRP HD1 . 34783 1 14 . 1 . 1 108 108 TRP HE1 H 1 7.109 0.020 . 1 . . . . A 108 TRP HE1 . 34783 1 15 . 1 . 1 108 108 TRP HE3 H 1 7.109 0.020 . 1 . . . . A 108 TRP HE3 . 34783 1 16 . 1 . 1 113 113 PHE HD1 H 1 6.411 0.020 . 1 . . . . A 113 PHE HD1 . 34783 1 17 . 1 . 1 113 113 PHE HD2 H 1 6.411 0.020 . 1 . . . . A 113 PHE HD2 . 34783 1 18 . 1 . 1 113 113 PHE HE1 H 1 6.872 0.020 . 1 . . . . A 113 PHE HE1 . 34783 1 19 . 1 . 1 113 113 PHE HE2 H 1 6.872 0.020 . 1 . . . . A 113 PHE HE2 . 34783 1 20 . 2 . 1 36 36 TYR HD1 H 1 6.228 0.020 . 1 . . . . B 36 TYR HD1 . 34783 1 21 . 2 . 1 36 36 TYR HD2 H 1 6.228 0.020 . 1 . . . . B 36 TYR HD2 . 34783 1 22 . 2 . 1 36 36 TYR HE1 H 1 6.976 0.020 . 1 . . . . B 36 TYR HE1 . 34783 1 23 . 2 . 1 36 36 TYR HE2 H 1 6.976 0.020 . 1 . . . . B 36 TYR HE2 . 34783 1 24 . 2 . 1 49 49 PHE HE1 H 1 7.222 0.020 . 1 . . . . B 49 PHE HE1 . 34783 1 25 . 2 . 1 49 49 PHE HE2 H 1 7.222 0.020 . 1 . . . . B 49 PHE HE2 . 34783 1 26 . 2 . 1 106 106 VAL HG11 H 1 0.808 0.020 . 2 . . . . B 106 VAL HG11 . 34783 1 27 . 2 . 1 106 106 VAL HG12 H 1 0.808 0.020 . 2 . . . . B 106 VAL HG12 . 34783 1 28 . 2 . 1 106 106 VAL HG13 H 1 0.808 0.020 . 2 . . . . B 106 VAL HG13 . 34783 1 29 . 2 . 1 106 106 VAL HG21 H 1 0.476 0.020 . 2 . . . . B 106 VAL HG21 . 34783 1 30 . 2 . 1 106 106 VAL HG22 H 1 0.476 0.020 . 2 . . . . B 106 VAL HG22 . 34783 1 31 . 2 . 1 106 106 VAL HG23 H 1 0.476 0.020 . 2 . . . . B 106 VAL HG23 . 34783 1 32 . 2 . 1 108 108 TRP HD1 H 1 7.077 0.020 . 1 . . . . B 108 TRP HD1 . 34783 1 33 . 2 . 1 108 108 TRP HE1 H 1 7.109 0.020 . 1 . . . . B 108 TRP HE1 . 34783 1 34 . 2 . 1 108 108 TRP HE3 H 1 7.109 0.020 . 1 . . . . B 108 TRP HE3 . 34783 1 35 . 2 . 1 113 113 PHE HD1 H 1 6.411 0.020 . 1 . . . . B 113 PHE HD1 . 34783 1 36 . 2 . 1 113 113 PHE HD2 H 1 6.411 0.020 . 1 . . . . B 113 PHE HD2 . 34783 1 37 . 2 . 1 113 113 PHE HE1 H 1 6.872 0.020 . 1 . . . . B 113 PHE HE1 . 34783 1 38 . 2 . 1 113 113 PHE HE2 H 1 6.872 0.020 . 1 . . . . B 113 PHE HE2 . 34783 1 39 . 3 . 1 36 36 TYR HD1 H 1 6.228 0.020 . 1 . . . . C 36 TYR HD1 . 34783 1 40 . 3 . 1 36 36 TYR HD2 H 1 6.228 0.020 . 1 . . . . C 36 TYR HD2 . 34783 1 41 . 3 . 1 36 36 TYR HE1 H 1 6.976 0.020 . 1 . . . . C 36 TYR HE1 . 34783 1 42 . 3 . 1 36 36 TYR HE2 H 1 6.976 0.020 . 1 . . . . C 36 TYR HE2 . 34783 1 43 . 3 . 1 49 49 PHE HE1 H 1 7.222 0.020 . 1 . . . . C 49 PHE HE1 . 34783 1 44 . 3 . 1 49 49 PHE HE2 H 1 7.222 0.020 . 1 . . . . C 49 PHE HE2 . 34783 1 45 . 3 . 1 106 106 VAL HG11 H 1 0.808 0.020 . 2 . . . . C 106 VAL HG11 . 34783 1 46 . 3 . 1 106 106 VAL HG12 H 1 0.808 0.020 . 2 . . . . C 106 VAL HG12 . 34783 1 47 . 3 . 1 106 106 VAL HG13 H 1 0.808 0.020 . 2 . . . . C 106 VAL HG13 . 34783 1 48 . 3 . 1 106 106 VAL HG21 H 1 0.476 0.020 . 2 . . . . C 106 VAL HG21 . 34783 1 49 . 3 . 1 106 106 VAL HG22 H 1 0.476 0.020 . 2 . . . . C 106 VAL HG22 . 34783 1 50 . 3 . 1 106 106 VAL HG23 H 1 0.476 0.020 . 2 . . . . C 106 VAL HG23 . 34783 1 51 . 3 . 1 108 108 TRP HD1 H 1 7.077 0.020 . 1 . . . . C 108 TRP HD1 . 34783 1 52 . 3 . 1 108 108 TRP HE1 H 1 7.109 0.020 . 1 . . . . C 108 TRP HE1 . 34783 1 53 . 3 . 1 108 108 TRP HE3 H 1 7.109 0.020 . 1 . . . . C 108 TRP HE3 . 34783 1 54 . 3 . 1 113 113 PHE HD1 H 1 6.411 0.020 . 1 . . . . C 113 PHE HD1 . 34783 1 55 . 3 . 1 113 113 PHE HD2 H 1 6.411 0.020 . 1 . . . . C 113 PHE HD2 . 34783 1 56 . 3 . 1 113 113 PHE HE1 H 1 6.872 0.020 . 1 . . . . C 113 PHE HE1 . 34783 1 57 . 3 . 1 113 113 PHE HE2 H 1 6.872 0.020 . 1 . . . . C 113 PHE HE2 . 34783 1 58 . 4 . 2 1 1 VIU H19 H 1 1.857 0.020 . 2 . . . . D 201 VIU H19 . 34783 1 59 . 4 . 2 1 1 VIU H1A H 1 1.857 0.020 . 2 . . . . D 201 VIU H1A . 34783 1 60 . 4 . 2 1 1 VIU H17 H 1 3.314 0.020 . 2 . . . . D 201 VIU H17 . 34783 1 61 . 4 . 2 1 1 VIU H18 H 1 3.314 0.020 . 2 . . . . D 201 VIU H18 . 34783 1 62 . 4 . 2 1 1 VIU H1B H 1 1.857 0.020 . 2 . . . . D 201 VIU H1B . 34783 1 63 . 4 . 2 1 1 VIU H1C H 1 1.857 0.020 . 2 . . . . D 201 VIU H1C . 34783 1 64 . 4 . 2 1 1 VIU H1D H 1 3.309 0.020 . 2 . . . . D 201 VIU H1D . 34783 1 65 . 4 . 2 1 1 VIU H1E H 1 3.309 0.020 . 2 . . . . D 201 VIU H1E . 34783 1 66 . 4 . 2 1 1 VIU H0S H 1 6.696 0.020 . 1 . . . . D 201 VIU H0S . 34783 1 67 . 4 . 2 1 1 VIU H0T H 1 6.502 0.020 . 1 . . . . D 201 VIU H0T . 34783 1 68 . 4 . 2 1 1 VIU H0U H 1 6.506 0.020 . 1 . . . . D 201 VIU H0U . 34783 1 69 . 4 . 2 1 1 VIU H11 H 1 1.870 0.020 . 2 . . . . D 201 VIU H11 . 34783 1 70 . 4 . 2 1 1 VIU H12 H 1 1.870 0.020 . 2 . . . . D 201 VIU H12 . 34783 1 71 . 4 . 2 1 1 VIU H0Z H 1 3.308 0.020 . 2 . . . . D 201 VIU H0Z . 34783 1 72 . 4 . 2 1 1 VIU H10 H 1 3.308 0.020 . 2 . . . . D 201 VIU H10 . 34783 1 73 . 4 . 2 1 1 VIU H13 H 1 1.870 0.020 . 2 . . . . D 201 VIU H13 . 34783 1 74 . 4 . 2 1 1 VIU H14 H 1 1.870 0.020 . 2 . . . . D 201 VIU H14 . 34783 1 75 . 4 . 2 1 1 VIU H15 H 1 3.309 0.020 . 2 . . . . D 201 VIU H15 . 34783 1 76 . 4 . 2 1 1 VIU H16 H 1 3.309 0.020 . 2 . . . . D 201 VIU H16 . 34783 1 77 . 4 . 2 1 1 VIU H0V H 1 6.769 0.020 . 1 . . . . D 201 VIU H0V . 34783 1 78 . 4 . 2 1 1 VIU H0W H 1 2.370 0.020 . 1 . . . . D 201 VIU H0W . 34783 1 79 . 4 . 2 1 1 VIU H0X H 1 2.370 0.020 . 1 . . . . D 201 VIU H0X . 34783 1 80 . 4 . 2 1 1 VIU H0Y H 1 2.370 0.020 . 1 . . . . D 201 VIU H0Y . 34783 1 81 . 4 . 2 1 1 VIU H1F H 1 2.812 0.020 . 2 . . . . D 201 VIU H1F . 34783 1 82 . 4 . 2 1 1 VIU H1G H 1 2.812 0.020 . 2 . . . . D 201 VIU H1G . 34783 1 83 . 4 . 2 1 1 VIU H1H H 1 1.176 0.020 . 1 . . . . D 201 VIU H1H . 34783 1 84 . 4 . 2 1 1 VIU H1I H 1 1.176 0.020 . 1 . . . . D 201 VIU H1I . 34783 1 85 . 4 . 2 1 1 VIU H1J H 1 1.176 0.020 . 1 . . . . D 201 VIU H1J . 34783 1 stop_ save_