Biological Magnetic Resonance Data Bank

A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
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Selected Calmodulin Bibliography

Introduction Function Sequence Details BMRB and PDB entries Bibliography

NMR Publications

  1. Afshar, M., Caves, L.S., Guimard, L., Hubbard, R.E., Calas, B., Grassy, G., Haiech, J. (1994) Investigating the High Affinity and Low Sequence Specificity of Calmodulin Binding to Its Targets. J. Mol. Biol. 244, 554-71.
  2. Amodeo, P., Castiglione Morelli, M.A.; Strazzullo, G. (2001) Kinase recognition by calmodulin: modeling the interaction with the autoinhibitory region of human cardiac titin kinase. J. Mol. Biol. 306, 81-95.
  3. Barbato, G., Kay, L.E., Ikura, M., Bax, A. (1991) Backbone Dynamics of Calmodulin as Studied by Super(15)N Inverse Detected NMR. 1991 Keystone Colloquium on the Frontiers of NMR in Molecular Biology - II.
  4. Bentrop, D., Bertini, I., Cremonini, M.A., Forsen, S., Luchinat, C., Malmendal, A. (1997) Solution structure of the paramagnetic complex of the N-terminal domain of calmodulin with two Ce3+ ions by 1H NMR. Biochemistry 36, 11605-18.
  5. Bertini, I., Del Bianco, C., Gelis, I. (2004) Experimentally Exploring the Conformational Space Sampled by Domain Reorientation in Calmodulin. Proc. Natl. Acad. Sci. U. S. A. 101, 6841-6.
  6. Biekofsky, R.R., Martin, S.R., McCormick, J.E., Masino, L., Fefeu, S., Bayley, P.M., Feeney, J. (2002) Thermal stability of calmodulin and mutants studied by (1)H-(15)N HSQC NMR measurements of selectively labeled [(15)N]Ile proteins. Biochemistry 41, 6580-9.
  7. Bouvier, D., Vanhaverbeke, C., Simorre, J.P., Gans, P. (2003) Unusual Ca(2+)-calmodulin Binding Interactions of the Microtubule-associated Protein F-STOP. Biochemistry 42, 11484-93.
  8. Chang, S.L., Szabo, A., Tjandra, N. (2003) Temperature Dependence of Domain Motions of Calmodulin Probed by NMR Relaxation at Multiple Fields. J. Am. Chem. Soc. 125, 11379-84.
  9. Chazin, W.J. (1995) Releasing the Calcium Trigger. Nat. Struct. Mol. Biol. 2, 707-10.
  10. Chen, C., Feng, Y., Short, J.H., Wand A.J. (1993) The Main Chain Dynamics of a Peptide Bound to Calmodulin. Arch. Biochem. Biophys. 306, 510-4.
  11. Cheung, W.Y. (1970) Cyclic 3', 5'-nucleotide phosphodiesterase. Demonstration of an activator. Biochem. Biophys. Res. Commun. 38, 533-88.
  12. Cheung, W.Y. (1971) Cyclic 3',5'-nucleotide phosphodiesterase. Evidence for and properties of a protein activator. J. Biol. Chem. 246, 2859-69.
  13. Clore, G.M., Gronenborn, A.M. (1994) Structures of Larger Proteins, Protein-ligand and Protein-DNA Complexes by Multi-dimensional Heteronuclear NMR. Prog. Biophys. Mol. Biol. 62, 153-84.
  14. Clore, G.M., and Gronenborn, A.M. (1994) Young Investigator Award Lecture. Structures of Larger proteins, Protein-ligand and Protein-DNA complexes by Multidimensional Heteronuclear NMR. Protein Sci. 3, 372-90.
  15. Craescu, C.T., Bouhss, A., Mispelter, J., Diesis, E., Popescu, A., Chiriac, M., Barzu, O. (1995) Calmodulin binding of a peptide derived from the regulatory domain of Bordetella pertussis adenylate cyclase. J. Biol. Chem. 270, 7088-96 (1995).
  16. David, A.D., McIntyre, D.D., and Vogel, H.J. (1995) Biochemical and Two Dimensional NMR Studies of Fluoro-Tyr and Fluoro-Phe Calmodulin. 8th Annual Meeting of the Canadian Federation of Biological Sciences.
  17. Ehrhardt, M.R., Urbauer, J.L., Wand, A.J. (1995) The Energetics and Dynamics of Molecular Recognition by Calmodulin. Biochemistry 34, 2731-8.
  18. Elshorst, B., Hennig, M., Forsterling, H., Diener, A., Maurer M., Schulte, P., Schwalbe, H., Griesinger, C., Krebs, J., Schmid, H., Vorherr, T., Carafoli, E. (1999) NMR Solution Structure of a Complex of Calmodulin with a Binding Peptide of the Ca2+ Pump. Biochemistry 38, 12320-32.
  19. Findlay, W.A., Gradwell, M.J., Bayley, P.M. (1995) ole of the N-terminal Region of the Skeletal Muscle Myosin Light Chain Kinase Target Sequence in Its Interaction with Calmodulin. Protein Sci. 4, 2375-82.
  20. Finn, B.E., Drakenberg, T., Forsen, S. (1993) The Structure of Apo-calmodulin. A 1H NMR Examination of the Carboxy-terminal Domain. FEBS Lett. 336, 368-74.
  21. Finn, B.E., Wikstroem, M., Drakenberg, T., Thulin, E., Akke, M., Forsen, S. (1993) Calcium-induced Activation of Calmodulin Examined by Super(1)H and Super(15)N NMR. Frontiers of NMR in Molecular Biology III
  22. Fisher, P.J., Prendergast, F.G., Ehrhardt, M.R., Urbauer, J.L., Wand, A.J., Sedarous, S.S., McCormick, D.J., Buckley, P.J. (1994) Calmodulin Interacts with Amphiphilic Peptides Composed of All D-amino Acids. Nature 368, 651-3.
  23. Grzesiek, S., Bax, A. (1995) Spin-locked Multiple Quantum Coherence for Signal Enhancement in Heteronuclear Multidimensional NMR Experiments. J. Biomol. NMR 6, 335-9.
  24. Hardy, R.W., McDonald, J.M., Remsen, E.E., d'Avignon, D.A., Sacks, D.B. (1994) The interaction of calmodulin and polylysine as studied by 1H NMR spectroscopy and sedimentation equilibrium centrifugation. Biochem. Biophys. Res. Commun. 198, 309-17.
  25. Hardy, R., Sacks, D., D'Avignon, A., Remsen, E., McDonald, J. (1990) Investigation of the Interaction of Calmodulin and Polylysine Using Super(1)H NMR Spectroscopy and Sedimentation Equilibrium. ASBMB/AAI Joint Meeting
  26. Hayashi, N., Nakagawa, C., Ito, Y. (2004) Myristoylation-regulated Direct Interaction Between Calcium-bound Calmodulin and N-terminal Region of pp60v-src. J. Mol. Biol. 338, 169-80.
  27. Hinche, M.T., Sykes, B.D., Kay, C.M. (1981) Laser Photochemically Induced Dynamic Nuclear Polarization Proton Nuclear Magnetic Resonance Studies on Three Homologous Calcium Binding Proteins: Cardiac Troponin-C, Skeletal Troponin-C, and Calmodulin. Biochemistry 20, 4185-93.
  28. Hu, J., Jia, X., Li, Q., Yang, X., Wang, K. (2004) Binding of La3+ to Calmodulin and Its Effects on the Interaction between Calmodulin and Calmodulin Binding Peptide, Polistes Mastoparan. Biochemistry 43, 2688-98.
  29. Huque, M.E., Vogel, H.J. (1993) Carbon-13 NMR Studies of the Lysine Side Chains of Calmodulin and its Proteolytic Fragments. J. Prot. Chem. 12, 695-707.
  30. Ikura, M. Haraoki, T., Hikichi, K., Mikuni, T., Yazawa, M., Yagi, K. (1983) Nuclear Magnetic Resonance Studies on Calmodulin: Calcium-Induced Conformational Change. Biochemistry 22, 2573-9.
  31. Ikura, M., Kay, L.E., Bax, A. (1990) A Novel Approach for Sequential Assignment of 1H, 13C, and 15N Spectra of Larger Proteins: Heteronuclear Triple-Resonance Three-Dimensional NMR Spectroscopy. Application to Calmodulin. Biochemistry 29, 4659-67.
  32. Ikura, M., Kay, L.E., Krinks, M., Bax, A. (1991) Triple-Resonance Multidimensional NMR Study of Calmodulin Complexed with the Binding Domain of Skeletal Muscle Myosin Light-Chain Kinase: Indication of a Conformational Change in the Central Helix. Biochemistry 30, 5498-504
  33. Ikura, M., Spera, S., Barbato, G., Kay, L., Zhu, G., Clore, M. (1991) Multi-nuclear Multi-dimensional NMR Study on Calmodulin and Its Complex with a Myosin Light-chain Kinase Fragment. 1991 Keystone Colloquium on the Frontiers of NMR in Molecular Biology - II
  34. Ishida, H., Nakashima, K., Kumaki, Y., Nakata, M., Hikichi, K., Yazawa, M. (2002) Letter to the Editor: 1H, 15N and 13C resonance assignments of yeast Saccharomyces cerevisiae calmodulin in the Ca2+-free state. J. Biomol. NMR 23, 323-4.
  35. Ishida, H.; Takahashi, K.; Nakashima, K.I. (2000) Solution structures of the N-terminal domain of yeast calmodulin: Ca2+-dependent conformational change and its functional implication. Biochemistry 39, 13660-8.
  36. Jaren, O. R., Kranz, J. K., Sorensen, B. R., Wand, A. J., Shea, M. A. (2002) Calcium-Induced Conformational Switching of Paramecium Calmodulin Provides Evidence for Domain Coupling. Biochemistry 41, 14158-66.
  37. Kakiuchi, S., Yamazaki, R. (1970) Calcium dependent phosphodiesterase activty and its activating factor (PAF) from brain studies on cyclic 3', 5'-nucleotide phosphodiestrase (3). Biochem. Biophys. Res. Commun. 41, 1104-10.
  38. Klee, C.B.,Crouch, T.H., Richman, P.G. (1980) Calmodulin. Annu. Rev. Biochem. 49, 489-515.
  39. Kranz, J. K., Flynn, P. F., Fuentes, E. J., Wand, A. J. (2002) Dissection of the Pathway of Molecular Recognition by Calmodulin. Biochemistry 41, 2599-608.
  40. Kuboniwa, H., Grzesiek, S., Delaglio, F., Bax, A. (1994) Measurement of HN-H Alpha J Couplings in Calcium-free Calmodulin Using New 2D and 3D Water-flip-back Methods. J. Biomol. NMR 4, 871-8.
  41. Kuboniwa, H., Tjandra, N., Grzesiek, S., Ren, H., Klee, CB., Bax, A. (1995) Solution Structure of Calcium-Free Calmodulin. Nat. Struct. Biol. 2, 768-76
  42. Kurokawa, H., Osawa, M., Kurihara, H. (2001) Target-induced conformational adaptation of calmodulin revealed by the crystal structure of a complex with nematode Ca2+/calmodulin-dependent kinase kinase peptide. J. Mol. Biol. 312, 59-68
  43. Larsson, G., Schleucher, J., Onions, J., Hermann, S., Grundstrom, T., Wijmenga, S. (2001) A Novel Target Recognition Revealed by Calmodulin in Complex with the Basic Helix-loop-helix Transcription Factor SEF2-1/E2-2. Protein Sci. 10, 169-86.
  44. Laws, D.D., de Dios, A.C., Oldfield, E. (1993) NMR Chemical Shifts and Structure Refinement in Proteins. . Biomol. NMR 3, 607-12.
  45. Lee, A.L., Wand, A.J. (2001) NMR Relaxation data for Protein Calmodulin in complex with the smooth muscle myosin light chain kinase calmodulin binding domain. Nature 411, 501-4.
  46. Lee, H.W., Yang, W., Ye, Y., Liu, Z.R., Glushka, J., Yang, J.J. (2002) Isolated EF-loop III of calmodulin in a scaffold protein remains unpaired in solution using pulsed-field-gradient NMR spectroscopy. Biochim. Biophys. Acta 1598, 80-7.
  47. Lee, A. L., Sharp, K. A., Kranz, J. K., Song, X.J., Wand, A. J. (2002) Temperature Dependence of the Internal Dynamics of a Calmodulin-Peptide Complex. Biochemistry 41, 13814-93.
  48. Lin, T.H., Huang, J.W., Huang, H.B., Chen, Y.C., Liu, C.Y, Lo, C.J., Tang, T.C., Chyan, C.L. (2004) Letter to the Editor: 1H, 15N, and 13C Resonance Assignments of Calmodulin Complexed with the Calmodulin-Binding Domain of calcineurin. J. Biomol. NMR 29, 531-2.
  49. Linse, S., Jonsson, B., Chazin, W.J. (1995) The Effect of Protein Concentration on Ion Binding. Proc. Nat. Acad. Sci. U. S. A. 92, 4748-52.
  50. Mal, T.K., Skrynnikov, N.R., Yap, K.L. (2002) Detecting Protein Kinase Recognition Modes of Calmodulin by Residual Dipolar Couplings in Solution NMR. Biochemistry 41, 12899-906.
  51. Malmendal, A., Evenas, J., Thulin, E., Gippert G.P., Drakenberg, T., Forsen, S. (1998) When Size is Important: Accomodation of Magnesium in a Calcium Binding Regulatory Domain. J. Biol. Chem. 273, 28944-9001.
  52. Malmendal, A., Linse, S., Evenas, J. (1999) Battle for the EF-hands: magnesium-calcium interference in calmodulin. Biochemistry 38 38, 11844-50.
  53. Matsubara, M., Hayashi, N., Titani, K., Taniguchi, H. (1997) Circular dichroism and 1H NMR studies on the structures of peptides derived from the calmodulin-binding domains of inducible and endothelial nitric-oxide synthase in solution and in complex with calmodulin. Nascent alpha-helical structures are stabilized by calmodulin both in the presence and absence of Ca2+. J. Biol. Chem. 272, 23050-6.
  54. Moser, M.J., Lee, S.Y., Klevit, R.E. Davis, T.N. (1995) Ca2+ binding to calmodulin and its role in Schizosaccharomyces pombe as revealed by mutagenesis and NMR spectroscopy. J. Biol. Chem. 20643-52.
  55. Munier, H., Bouhss, A., Gilles, A.M., Palibroda, N., Barzu, O., Mispelter, J., Craescu, C.T. (1995) Structural characterization by nuclear magnetic resonance spectroscopy of a genetically engineered high-affinity calmodulin-binding peptide derived from Bordetella pertussis adenylate cyclase. Arch. Biochem. Biophys. 320, 224-35.
  56. Ohki, S., Iwamoto, U., Aimoto, S., Yazawa, M., Hikichi, K. (1993) Mg2+ inhibits formation of 4Ca(2+)-calmodulin-enzyme complex at lower Ca2+ concentration. 1H and 113Cd NMR studies. J. Biol. Chem. 268, 12388-92.
  57. Ohki, S., Miurac, K., Saitoc, M., Nakashimac, K., Maekawa, H., Yazawac, M., Tsudac, S., Hikichi, K. (1996) Secondary structure and Ca(2+)-binding property of the N-terminal half domain of calmodulin from yeast Saccharomyces cerevisiae as studied by NMR. J. Biochem. 119, 1045-55.
  58. Orsale, M., Melino, S., Contessa, G.M., Torre, V., Andreotti, G., Motta, A., Paci, M., Desideri, A., Cicero, D.O. (2003) Two distinct calcium-calmodulin interactions with N-terminal regions of the olfactory and rod cyclic nucleotide-gated channels characterized by NMR spectroscopy. FEBS Lett. 548, 11-6.
  59. Osawa, M., Swindells, M.B., Tanikawa, J., Tanaka T., Toshiyuki T., Mase, T., Furaya, T., Ikura, M. (1997) Solution Structure of Calmodulin-W-7 Complex: The Basis of Diversity in Molecular Recognition. J. Mol. Biol. 276, 165-76.
  60. Osawa, M., Tokumitsu, H., Swindells, M.B., Kurihara, H., Orita, M., Shibanuma, M., Furaya, T., Ikura, M. (1999) A Novel Target Recognition Revealed by Calmodulin in Complex with Ca2+-calmodulin-dependent Kinase Kinase. Nat. Struct. Biol. 6, 819-24.
  61. Ouyang, H., Vogel, H.J. (1998) Melatonin and serotonin interactions with calmodulin: NMR, spectroscopic and biochemical studies. Biochim. Biophys. Acta. 1383, 37-47.
  62. Ouyang, H., Vogel, H.J.(1995) Metal ion binding to calmodulin: NMR and fluorescence studies. Biometals 11, 213-22.
  63. Pedigo, S. Shea, M.A. (1995) Discontinuous equilibrium titrations of cooperative calcium binding to calmodulin monitored by 1-D 1H-nuclear magnetic resonance spectroscopy. Biochemistry 34, 10676-89
  64. Porumb, T., Yau, P., Harvey, T.S., Ikura, M. (1994) A calmodulin-target peptide hybrid molecule with unique calcium-binding properties. Protein Eng. 7, 109-115.
  65. Prabhu, N.V., Lee, A.L., Wand, A.J., Sharp, K.A. (2003) Dynamics and entropy of a calmodulin-peptide complex studied by NMR and molecular dynamics. Biochemistry 42, 562-70.
  66. Seeholzer, S.H., Wand, A.J. (1989) Structural Characterization of the Interactions between Calmodulin and Skeletal Muscle Myosin Light Chain Kinase: Effect of Peptide (576-594)G Binding on the Ca2+-Binding Domains. Biochemistry 28, 4011-20.
  67. Sekharudu, C.Y., Sundaralingam, M. (1993) A model for the calmodulin-peptide complex based on the troponin C crystal packing and its similarity to the NMR structure of the calmodulin-myosin light chain kinase peptide complex. Protein Sci. 2, 620-5.
  68. Siivari, K., Zhang, M., Palmer, A.G., Vogel, H.J. (1995) NMR studies of the methionine methyl groups in calmodulin. FEBS Lett. 366, 104-8.
  69. Skelton, N.J., Kordel, J., Akke, M., Forsen, S., Chazin, W.J. (1994) Signal transduction versus buffering activity in Ca(2+)-binding proteins. Nat. Struct. Biol. 1, 239-245.
  70. Slupsky, C.M., Reinach, F.C., Smillie, L.B., Sykes, B.D. (1995) Solution secondary structure of calcium-saturated troponin C monomer determined by multidimensional heteronuclear NMR spectroscopy. Protein Sci. 4, 1279-90.
  71. Teo, T.S., Wang, J.H. (1973) Mechanism of activation of a cyclic adenosine 3':5'-monophosphate phosphodiesterase from bovine heart by calcium ions. Identification of the protein activator as a Ca2+ binding protein. J. Biol. Chem. 248, 5950-5.
  72. Tjandra, N., Kuboniwa, H., Ren, H., Bax, A. (1995) Rotational dynamics of calcium-free calmodulin studied by 15N-NMR relaxation measurements. Eur. J. Biochem. 230, 1014-24.
  73. Trave, G., Lacombe, P.J., Pfuhl, M., Saraste, M., Pastore, A. (1995) Molecular mechanism of the calcium-induced conformational change in the spectrin EF-hands. EMBO J. 14, 4922-31.
  74. Turjanski, A.G., Estrin, D.A., Rosenstein, R.E., McCormick, J.E., Martin, S.R., Pastore, A., Biekofsky, R.R., Martorana, V. (2004) NMR and molecular dynamics studies of the interaction of melatonin with calmodulin. Protein Sci. 13, 2925-38.
  75. Urbauer, J.L., Short, J.H., Dow, L.K., Wand, A.J. (1995) tructural analysis of a novel interaction by calmodulin: high-affinity binding of a peptide in the absence of calcium. Biochemistry 34, 8099-109.
  76. Vogel, H.J. (1994) The Merck Frosst Award Lecture 1994. Calmodulin: a versatile calcium mediator protein. Biochem. Cell. Biol. 72, 357-76.
  77. Vogel, H.J., Zhang, M. (1995) Protein engineering and NMR studies of calmodulin. Mol. Cell. Biochem. 149-150, 3-15.
  78. Wang, T., Frederick, K.K., Igumenova, T.I., Wand, A.J., Zuiderweg, E.R. (2005) Changes in Calmodulin Main-Chain Dynamics upon Ligand Binding Revealed by Cross-Correlated NMR Relaxation Measurements. J. Am. Chem. Soc. 127, 828-9.
  79. Weinstein, H., Mehler, E.L. (1994) Ca2+-Binding and Structural Dynamics in the Functions of Calmodulin. Annu. Rev. Physiol. 56, 213-36.
  80. Wissmann, R., Bildl, W., Neumann, H., Rivard, A.F., Kloecker, N., Weitz, D., Schulte, U., Adelman, J.P., Bentrop, D., Fakler, B. (2002) A helical region in the C-terminus of small-conductance Ca2+-activated K+ channels controls assembly with apo-calmodulin. J. Biol. Chem. 277, 2558-64.
  81. Yamniuk, A. P., Vogel, H. J. (2005) Structural Investigation into the Differential Target Enzyme Regulation Displayed by Plant Calmodulin Isoforms. Biochemistry 44, 3101-11.
  82. Yap, K.L., Yuan, T., Mal, T.K., Vogel, H.J., Ikura, M. (2003) Structural basis for simultaneous binding of two carboxy-terminal peptides of plant glutamate decarboxylase to calmodulin. J. Mol. Biol. 328, 193-204.
  83. Yuan, T., Mietzner, T.A., Montelaro, R.C., Vogel, H.J. (1995) Characterization of the calmodulin binding domain of SIV transmembrane glycoprotein by NMR and CD spectroscopy. Biochemistry 34, 10690-6.
  84. Yuan, T., Ouyang, H., Vogel, H.J. (1999) Surface exposure of the methionine side chains of calmodulin in solution. A nitroxide spin label and two-dimensional NMR study. J. Biol. Chem. 274, 8411-20.
  85. Zhang, M., Huque, E., Vogel, H.J. (1994) Characterization of trimethyllysine 115 in calmodulin by 14N and 13C NMR spectroscopy. J. Biol. Chem. 269, 5099-105.
  86. Zhang, M., Tanaka, T., Ikura, M. (1995) Calcium-induced conformational transition revealed by the solution structure of apo calmodulin. Nat. Stuct. Biol. 2, 758-67.
  87. Zhang, M., Vogel, H.J. (1994) Two-dimensional NMR studies of selenomethionyl calmodulin. J. Mol. Biol. 239, 545-54.
  88. Zhang, M., Vogel, H.J. (1994) The calmodulin-binding domain of caldesmon binds to calmodulin in an alpha-helical conformation. Biochemistry 33, 1163-1171.
  89. Zhang, M., Vogel, H.J. (1994) Characterization of the calmodulin-binding domain of rat cerebellar nitric oxide synthase. J. Biol. Chem. 269, 981-5.
  90. Zhang, M., Vogel, H.J. (1993) Determination of the side chain pKa values of the lysine residues in calmodulin. J. Biol. Chem. 268, 22420-8.
  91. Zhang, M., Vogel, H.J., Zwiers, H. (1994) Nuclear magnetic resonance studies of the structure of B50 /neuromodulin and its interaction with calmodulin. Biochem. Cell. Biol. 72, 109-16.
  92. Zhang, M., Yuan, T., Aramini, J.M., Vogel, H.J. (1995) Interaction of calmodulin with its binding domain of rat cerebellar nitric oxide synthase. A multinuclear NMR study. J. Biol. Chem. 270, 20901-7.
  93. Zhang, M., Yuan, T., Vogel, H.J. (1993) A peptide analog of the calmodulin-binding domain of myosin light chain kinase adopts an alpha-helical structure in aqueous trifluoroethanol. Protein Sci. 2, 1931-7.
  94. Zhou, N., Yuan, T., Mak, A.S., Voge, H.J. (1997) NMR studies of caldesmon-calmodulin interactions. Biochemistry 36, 2817-25.
  95. Zhou, Y., Li, Y., Wang, Z., Ou, Y., Zhou, X. (1994) 1H NMR and spin-labeled EPR studies on the interaction of calmodulin with jujuboside A. Biochem. Biophys. Res. Commun. 202, 148-54.