BMRB Entry 11573

Name: Solution structure of the human BMX SH2 domain
Published: 2018-12-11

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR11573

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solution structure of the human BMX SH2 domain

Deposition date:

2014-07-31

Original release date:

2018-12-11

Authors:

Kasai, Takuma; Koshiba, Seizo; Watanabe, Satoru; Harada, Takushi; Kigawa, Takanori; Yokoyama, Shigeyuki

Citation:

Citation: Kasai, Takuma; Koshiba, Seizo; Yokoyama, Jun; Kigawa, Takanori. "Stable isotope labeling strategy based on coding theory." J. Biomol. NMR 63, 213-221 (2015).
PubMed: 26293126

Assembly members:

Assembly members:
BMX_SH2_domain, polymer, 110 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: cell free synthesis Host organism: E. coli - cell free Vector: P061225-65

Entity Sequences (FASTA):

Entity Sequences (FASTA):
BMX_SH2_domain: GSSGSSGLDDYDWFAGNISR SQSEQLLRQKGKEGAFMVRN SSQVGMYTVSLFSKAVNDKK GTVKHYHVHTNAENKLYLAE NYCFDSIPKLIHYHQHNSAG MITRLRHPVS

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	468
15N chemical shifts	116
1H chemical shifts	739

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	BMX SH2 domain	1

Entities:

Entity 1, BMX SH2 domain 110 residues - Formula weight is not available

Residues 1-7 represent a non-native cloning artifact. This is the SH2 domain of human BMX protein.

1	GLY	SER	SER	GLY	SER	SER	GLY	LEU	ASP	ASP
2	TYR	ASP	TRP	PHE	ALA	GLY	ASN	ILE	SER	ARG
3	SER	GLN	SER	GLU	GLN	LEU	LEU	ARG	GLN	LYS
4	GLY	LYS	GLU	GLY	ALA	PHE	MET	VAL	ARG	ASN
5	SER	SER	GLN	VAL	GLY	MET	TYR	THR	VAL	SER
6	LEU	PHE	SER	LYS	ALA	VAL	ASN	ASP	LYS	LYS
7	GLY	THR	VAL	LYS	HIS	TYR	HIS	VAL	HIS	THR
8	ASN	ALA	GLU	ASN	LYS	LEU	TYR	LEU	ALA	GLU
9	ASN	TYR	CYS	PHE	ASP	SER	ILE	PRO	LYS	LEU
10	ILE	HIS	TYR	HIS	GLN	HIS	ASN	SER	ALA	GLY
11	MET	ILE	THR	ARG	LEU	ARG	HIS	PRO	VAL	SER

Name	Sample	Sample state	Sample conditions
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1

UNP	P51813
AlphaFold	Q12871

BMRB Entry 11573

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	SER	SER	GLY	SER	SER	GLY	LEU	ASP	ASP
2	TYR	ASP	TRP	PHE	ALA	GLY	ASN	ILE	SER	ARG
3	SER	GLN	SER	GLU	GLN	LEU	LEU	ARG	GLN	LYS
4	GLY	LYS	GLU	GLY	ALA	PHE	MET	VAL	ARG	ASN
5	SER	SER	GLN	VAL	GLY	MET	TYR	THR	VAL	SER
6	LEU	PHE	SER	LYS	ALA	VAL	ASN	ASP	LYS	LYS
7	GLY	THR	VAL	LYS	HIS	TYR	HIS	VAL	HIS	THR
8	ASN	ALA	GLU	ASN	LYS	LEU	TYR	LEU	ALA	GLU
9	ASN	TYR	CYS	PHE	ASP	SER	ILE	PRO	LYS	LEU
10	ILE	HIS	TYR	HIS	GLN	HIS	ASN	SER	ALA	GLY
11	MET	ILE	THR	ARG	LEU	ARG	HIS	PRO	VAL	SER

1	GLY	SER	SER	GLY	SER	SER	GLY	LEU	ASP	ASP
2	TYR	ASP	TRP	PHE	ALA	GLY	ASN	ILE	SER	ARG
3	SER	GLN	SER	GLU	GLN	LEU	LEU	ARG	GLN	LYS
4	GLY	LYS	GLU	GLY	ALA	PHE	MET	VAL	ARG	ASN
5	SER	SER	GLN	VAL	GLY	MET	TYR	THR	VAL	SER
6	LEU	PHE	SER	LYS	ALA	VAL	ASN	ASP	LYS	LYS
7	GLY	THR	VAL	LYS	HIS	TYR	HIS	VAL	HIS	THR
8	ASN	ALA	GLU	ASN	LYS	LEU	TYR	LEU	ALA	GLU
9	ASN	TYR	CYS	PHE	ASP	SER	ILE	PRO	LYS	LEU
10	ILE	HIS	TYR	HIS	GLN	HIS	ASN	SER	ALA	GLY
11	MET	ILE	THR	ARG	LEU	ARG	HIS	PRO	VAL	SER

1	GLY	SER	SER	GLY	SER	SER	GLY	LEU	ASP	ASP
2	TYR	ASP	TRP	PHE	ALA	GLY	ASN	ILE	SER	ARG
3	SER	GLN	SER	GLU	GLN	LEU	LEU	ARG	GLN	LYS
4	GLY	LYS	GLU	GLY	ALA	PHE	MET	VAL	ARG	ASN
5	SER	SER	GLN	VAL	GLY	MET	TYR	THR	VAL	SER
6	LEU	PHE	SER	LYS	ALA	VAL	ASN	ASP	LYS	LYS
7	GLY	THR	VAL	LYS	HIS	TYR	HIS	VAL	HIS	THR
8	ASN	ALA	GLU	ASN	LYS	LEU	TYR	LEU	ALA	GLU
9	ASN	TYR	CYS	PHE	ASP	SER	ILE	PRO	LYS	LEU
10	ILE	HIS	TYR	HIS	GLN	HIS	ASN	SER	ALA	GLY
11	MET	ILE	THR	ARG	LEU	ARG	HIS	PRO	VAL	SER