BMRB Entry 16416
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR16416
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Citation: Katoh, Etsuko; Louis, John; Yamazaki, Toshimasa; Gronenborn, Angela; Torchia, Dennis; Ishima, Rieko. "A solution NMR study of the binding kinetics and the internal dynamics of an HIV-1 protease-substrate complex." Protein Sci. 12, 1376-1385 (2003).
PubMed: 12824484
Assembly members:
HIV-PR, polymer, 99 residues, Formula weight is not available
substrate_C, polymer, 9 residues, Formula weight is not available
HIV-PR(D25N), polymer, 99 residues, Formula weight is not available
Natural source: Common Name: HIV Taxonomy ID: 12721 Superkingdom: not available Kingdom: not available Genus/species: not available not available
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: na
Entity Sequences (FASTA):
HIV-PR: PQVTLWKRPLVTIKIGGQLK
EALLDTGADDTVIEEMSLPG
RWKPKMIGGIGGFIKVRQYD
QIIIEIAGHKAIGTVLVGPT
PVNVIGRNLLTQIGATLNF
substrate_C: KARVXXQAX
HIV-PR(D25N): PQVTLWKRPLVTIKIGGQLK
EALLNTGADDTVIEEMSLPG
RWKPKMIGGIGGFIKVRQYD
QIIIEIAGHKAIGTVLVGPT
PVNVIGRNLLTQIGATLNF
- chemical_rates
| Data type | Count |
| binding constants | 1 |
| kinetic rates | 2 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | HIV-PR(D25N) | 1 |
| 2 | substrate C | 2 |
| 3 | HIV-PR(D25N) | 3 |
Entities:
Entity 1, HIV-PR(D25N) 99 residues - Formula weight is not available
| 1 | PRO | GLN | VAL | THR | LEU | TRP | LYS | ARG | PRO | LEU | ||||
| 2 | VAL | THR | ILE | LYS | ILE | GLY | GLY | GLN | LEU | LYS | ||||
| 3 | GLU | ALA | LEU | LEU | ASP | THR | GLY | ALA | ASP | ASP | ||||
| 4 | THR | VAL | ILE | GLU | GLU | MET | SER | LEU | PRO | GLY | ||||
| 5 | ARG | TRP | LYS | PRO | LYS | MET | ILE | GLY | GLY | ILE | ||||
| 6 | GLY | GLY | PHE | ILE | LYS | VAL | ARG | GLN | TYR | ASP | ||||
| 7 | GLN | ILE | ILE | ILE | GLU | ILE | ALA | GLY | HIS | LYS | ||||
| 8 | ALA | ILE | GLY | THR | VAL | LEU | VAL | GLY | PRO | THR | ||||
| 9 | PRO | VAL | ASN | VAL | ILE | GLY | ARG | ASN | LEU | LEU | ||||
| 10 | THR | GLN | ILE | GLY | ALA | THR | LEU | ASN | PHE |
Entity 2, substrate C 9 residues - Formula weight is not available
| 1 | LYS | ALA | ARG | VAL | NLE | PPN | GLN | ALA | NLE |
Entity 3, HIV-PR(D25N) 99 residues - Formula weight is not available
| 1 | PRO | GLN | VAL | THR | LEU | TRP | LYS | ARG | PRO | LEU | ||||
| 2 | VAL | THR | ILE | LYS | ILE | GLY | GLY | GLN | LEU | LYS | ||||
| 3 | GLU | ALA | LEU | LEU | ASN | THR | GLY | ALA | ASP | ASP | ||||
| 4 | THR | VAL | ILE | GLU | GLU | MET | SER | LEU | PRO | GLY | ||||
| 5 | ARG | TRP | LYS | PRO | LYS | MET | ILE | GLY | GLY | ILE | ||||
| 6 | GLY | GLY | PHE | ILE | LYS | VAL | ARG | GLN | TYR | ASP | ||||
| 7 | GLN | ILE | ILE | ILE | GLU | ILE | ALA | GLY | HIS | LYS | ||||
| 8 | ALA | ILE | GLY | THR | VAL | LEU | VAL | GLY | PRO | THR | ||||
| 9 | PRO | VAL | ASN | VAL | ILE | GLY | ARG | ASN | LEU | LEU | ||||
| 10 | THR | GLN | ILE | GLY | ALA | THR | LEU | ASN | PHE |
Related Database Links:
| PDB | 1A94 1DAZ 1DW6 1EBK 1FEJ 1FF0 1FFF 1FFI 1FG6 1FG8 1FGC 1Q9P 1SDT 1SDU 1SDV 2A1E 2AOC 2AOD 2AOE 2AOF 2AOG 2AOH 2AOI 2AOJ 2AVM 2AVO 2AVQ 2AVS 2AVV 2F80 2F81 2F8G 2G69 2HB3 2HS1 2HS2 2IDW 2IEN 2IEO 2NMY 2NMZ 2NNK 2NNP 2QCI 2QD6 2QD7 2QD8 2Z4O 2ZYE 3A2O 3B7V 3B80 3BVA 3BVB 3CYW 3CYX 3D1X 3D1Y 3D1Z 3D20 3DJK 3DK1 3FX5 3H5B 3I6O 3JVW 3JVY 3JW2 3K4V 3NDT 3NDU 3NDW 3NDX 3NU3 3NU4 3NU5 3NU6 3NU9 3NUJ 3NUO 3OK9 3OXC 3PWM 3PWR 3QAA 3ST5 3TKG 3TKW 3TL9 3TOF 3TOG 3TOH 3VF5 3VF7 3VFA 3VFB 4DFG 4EJ8 4EJL 4FL8 4FLG 4FM6 4HDB 4HDF 4HDP 4HE9 4HEG 4KB9 4U8W 4ZIP 4ZLS 5BRY 5BS4 |