BMRB Entry 16658

Title:
Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation
Deposition date:
2009-12-24
Original release date:
2010-05-20
Authors:
MIneev, Konstantin; Bocharov, Eduard; Pustovalova, Yulia; Bocharova, Olga; Chupin, Vladimir; Arseniev, Alexander
Citation:

Citation: Mineev, Konstantin; Bocharov, Eduard; Pustovalova, Yulia; Bocharova, Olga; Chupin, Vladimir; Arseniev, Alexander. "Spatial structure of the transmembrane domain heterodimer of ErbB1 and ErbB2 receptor tyrosine kinases."  J. Mol. Biol. 400, 231-243 (2010).
PubMed: 20471394

Assembly members:

Assembly members:
ErbB1TM, polymer, 44 residues, Formula weight is not available
ErbB2TM, polymer, 44 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: n/a

Entity Sequences (FASTA):

Data sets:
Data typeCount
13C chemical shifts351
15N chemical shifts78
1H chemical shifts661

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1EGFR TM segment1
2ErbB2 TM segment2

Entities:

Entity 1, EGFR TM segment 44 residues - Formula weight is not available

1   GLUGLYCYSPROTHRASNGLYPROLYSILE
2   PROSERILEALATHRGLYMETVALGLYALA
3   LEULEULEULEULEUVALVALALALEUGLY
4   ILEGLYLEUPHEMETARGARGARGHISILE
5   VALARGLYSARG

Entity 2, ErbB2 TM segment 44 residues - Formula weight is not available

1   GLYCYSPROALAGLUGLNARGALASERPRO
2   LEUTHRSERILEILESERALAVALVALGLY
3   ILELEULEUVALVALVALLEUGLYVALVAL
4   PHEGLYILELEUILELYSARGARGGLNGLN
5   LYSILEARGLYS

Related Database Links:

BMRB 18804 25729 15231
PDB 2KS1 2M0B 2N5S 2JWA
DBJ BAD92679 BAF83041 BAH11869 BAI46646 BAG58195 BAG62073 BAJ17684
EMBL CAA25240 CAA25282 CAA27060
GB AAG35789 AAG43243 AAH94761 AAS83109 AAT52212 AAA75493 AAI56756 AAI67147 AAO18082 AAX40997
PRF 1006266A 1202345A
REF NP_005219 XP_004045514 XP_008967087 XP_519102 NP_001005862 NP_001276865 NP_001276866 NP_004439 XP_001090319
SP P00533 P04626
AlphaFold P00533 P04626

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks