BMRB Entry 16967

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PDB ID: 2kyl
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR16967
MolProbity Validation Chart

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Title:
Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN
Deposition date:
2010-06-01
Original release date:
2012-09-20
Authors:
TERRIEN, Elouan; WOLFF, Nicolas; CORDIER, Florence; SIMENEL, Catherine; LAFON, Monique; DELEPIERRE, Muriel
Citation:

Citation: Terrien, Elouan; Chaffotte, Alain; Lafage, Mireille; Khan, Zakir; Prehaud, Christophe; Cordier, Florence; Simenel, Catherine; Delepierre, Muriel; Buc, Henri; Lafon, Monique; Wolff, Nicolas. "Interference with the PTEN-MAST2 Interaction by a Viral Protein Leads to Cellular Relocalization of PTEN."  Sci. Signal. 5, ra58-ra58 (2012).
PubMed: 22894835

Assembly members:

Assembly members:
MAST2-PDZ, polymer, 96 residues, 10452.032 Da.
PTEN-C_Terminus, polymer, 13 residues, 1559.692 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pDEST15

Entity Sequences (FASTA):

Entity Sequences (FASTA):
MAST2-PDZ: GGSMRPPIIIHRAGKKYGFT LRAIRVYMGDSDVYTVHHMV WHVEDGGPASEAGLRQGDLI THVNGEPVHGLVHTEVVELI LKSGNKVAISTTPLEN
PTEN-C_Terminus: PFDEDQHTQITKV

Data sets:
Data typeCount
13C chemical shifts406
15N chemical shifts96
1H chemical shifts664

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11
2entity_22

Entities:

Entity 1, entity_1 96 residues - 10452.032 Da.

Residue 1 is a non residue due to TEV cleavage site

1   GLYGLYSERMETARGPROPROILEILEILE
2   HISARGALAGLYLYSLYSTYRGLYPHETHR
3   LEUARGALAILEARGVALTYRMETGLYASP
4   SERASPVALTYRTHRVALHISHISMETVAL
5   TRPHISVALGLUASPGLYGLYPROALASER
6   GLUALAGLYLEUARGGLNGLYASPLEUILE
7   THRHISVALASNGLYGLUPROVALHISGLY
8   LEUVALHISTHRGLUVALVALGLULEUILE
9   LEULYSSERGLYASNLYSVALALAILESER
10   THRTHRPROLEUGLUASN

Entity 2, entity_2 13 residues - 1559.692 Da.

1   PROPHEASPGLUASPGLNHISTHRGLNILE
2   THRLYSVAL

Related Database Links:

BMRB 15972
PDB 2KQF 2KYL
DBJ BAA34527 BAB40778
EMBL CAD38775
GB AAH65499 EAX06948 EAX06949 EFB27522 EHB01606
REF NP_055927 XP_001105315 XP_002810932 XP_004025774 XP_004285802
SP Q6P0Q8
AlphaFold Q6P0Q8 Q6ICT7

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