BMRB Entry 17756
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17756
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Citation: Gerum, Christian; Silvers, Robert; Wirmer-Bartoschek, Julia; Schwalbe, Harald. "Unfolded-State Structure and Dynamics Influence the Fibril Formation of Human Prion Protein" Angew. Chem. Int. Ed. 48, 9452-9456 (2009).
PubMed: 19882604
Assembly members:
hPrP(121-230), polymer, 113 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pJC40(TEV)
Entity Sequences (FASTA):
hPrP(121-230): GHMVVGGLGGYMLGSAMSRP
IIHFGSDYEDRYYRENMHRY
PNQVYYRPMDEYSNQNNFVH
DCVNITIKQHTVTTTTKGEN
FTETDVKMMERVVEQMCITQ
YERESQAYYQRGS
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 254 |
| 1H chemical shifts | 177 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | human prion protein (residues 121-230) | 1 |
Entities:
Entity 1, human prion protein (residues 121-230) 113 residues - Formula weight is not available
Construct constitutes C-terminal domain (residues 121-230). First three residues are a remnant of the N-terminal (his)6 tag.
| 1 | GLY | HIS | MET | VAL | VAL | GLY | GLY | LEU | GLY | GLY | ||||
| 2 | TYR | MET | LEU | GLY | SER | ALA | MET | SER | ARG | PRO | ||||
| 3 | ILE | ILE | HIS | PHE | GLY | SER | ASP | TYR | GLU | ASP | ||||
| 4 | ARG | TYR | TYR | ARG | GLU | ASN | MET | HIS | ARG | TYR | ||||
| 5 | PRO | ASN | GLN | VAL | TYR | TYR | ARG | PRO | MET | ASP | ||||
| 6 | GLU | TYR | SER | ASN | GLN | ASN | ASN | PHE | VAL | HIS | ||||
| 7 | ASP | CYS | VAL | ASN | ILE | THR | ILE | LYS | GLN | HIS | ||||
| 8 | THR | VAL | THR | THR | THR | THR | LYS | GLY | GLU | ASN | ||||
| 9 | PHE | THR | GLU | THR | ASP | VAL | LYS | MET | MET | GLU | ||||
| 10 | ARG | VAL | VAL | GLU | GLN | MET | CYS | ILE | THR | GLN | ||||
| 11 | TYR | GLU | ARG | GLU | SER | GLN | ALA | TYR | TYR | GLN | ||||
| 12 | ARG | GLY | SER |
Related Database Links:
| BMRB | 15676 16743 16757 17714 17757 17780 18426 18550 19268 4379 4402 4434 4620 4641 4736 |
| PDB | 1E1G 1E1J 1E1P 1E1S 1E1U 1E1W 1FKC 1FO7 1H0L 1HJM 1HJN 1I4M 1QLX 1QLZ 1QM0 1QM1 1QM2 1QM3 2K1D 2KUN 2LEJ 2LFT 2LSB 2LV1 2M8T 2W9E 3HAF 3HAK 3HEQ 3HER 3HES 3HJ5 3HJX 4DGI 4KML 4N9O |
| DBJ | BAA00011 BAF62360 BAG32276 BAG32277 BAG32278 |
| EMBL | CAA58442 CAG46836 CAG46869 |
| GB | AAA19664 AAA60182 AAA68632 AAA68633 AAB59442 |
| REF | NP_000302 NP_001009093 NP_001073590 NP_001073591 NP_001073592 |
| SP | P04156 P40252 P61766 P61767 P61768 |
| AlphaFold | P04156 P40252 P61766 P61767 P61768 |