BMRB Entry 18804

Name: Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles
Published: 2013-10-22

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PDB ID: 2m0b
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18804
MolProbity Validation Chart

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles

Deposition date:

2012-10-24

Original release date:

2013-10-22

Authors:

Lesovoy, Dmitry; Bocharov, Eduard; Pustovalova, Yulia; Bocharova, Olga; Arseniev, Alexander

Citation:

Citation: Bocharov, Eduard; Lesovoy, Dmitry; Pustovalova, Yulia; Bocharova, Olga; Arseniev, Alexander. "Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles" To be Published ., .-..

Assembly members:

Assembly members:
ErbB1tm, polymer, 44 residues, 4733.881 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEMEX-1/(TRX-tmErbB1)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
ErbB1tm: EGCPTNGPKIPSIATGMVGA LLLLLVVALGIGLFMRRRHI VRKR

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	202
15N chemical shifts	46
1H chemical shifts	346

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	ErbB1 (EGFR, HER1), 1	1
2	ErbB1 (EGFR, HER1), 2	1

Entities:

Entity 1, ErbB1 (EGFR, HER1), 1 44 residues - 4733.881 Da.

1

GLU

GLY

CYS

PRO

THR

ASN

GLY

PRO

LYS

ILE

2

PRO

SER

ILE

ALA

THR

GLY

MET

VAL

GLY

ALA

3

LEU

VAL

ALA

LEU

GLY

4

ILE

GLY

LEU

PHE

MET

ARG

HIS

ILE

5

VAL

ARG

LYS

ARG

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-15N TROSY	sample_1	isotropic	sample_conditions_1
2D 1H-13C constant time HSQC aliphatic	sample_2	isotropic	sample_conditions_1
2D 1H-13C constant time HSQC aromatic	sample_2	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HN(CO)CA	sample_1	isotropic	sample_conditions_1
3D HN(CA)CO	sample_1	isotropic	sample_conditions_1
3D HNHA	sample_1	isotropic	sample_conditions_1
3D HNHB	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-15N(TROSY) NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C(constant time) NOESY aliphatic	sample_1	isotropic	sample_conditions_1
15N,13C-F1-filtered/F3-edited-NOESY	sample_1	isotropic	sample_conditions_1
15N,13C-F1-filtered/F3-edited-NOESY	sample_2	isotropic	sample_conditions_1

BMRB	16658 25729
PDB	2KS1 2M0B 2N5S
DBJ	BAD92679 BAF83041 BAH11869 BAI46646
EMBL	CAA25240 CAA25282
GB	AAG35789 AAG43243 AAH94761 AAS83109 AAT52212
PRF	1006266A
REF	NP_005219 XP_004045514 XP_008967087 XP_519102
SP	P00533
AlphaFold	P00533

BMRB Entry 18804

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

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