BMRB Entry 19290

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PDB ID: 4bs2
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19290
MolProbity Validation Chart

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Title:
NMR structure of human TDP-43 tandem RRMs in complex with UG-rich RNA
Deposition date:
2013-06-07
Original release date:
2013-06-28
Authors:
Lukavsky, Peter; Daujotyte, D.; Tollervey, J.; Ule, J.; Stuani, C.; Buratti, E.; Baralle, F.; Damberger, F.; Allain, F.
Citation:

Citation: Lukavsky, Peter; Daujotyte, Dalia; Tollervey, James; Ule, Jernej; Stuani, Cristiana; Buratti, Emanuele; Baralle, Francisco; Damberger, Fred; Allain, Frederic H-T. "Molecular basis of UG-rich RNA recognition by the human splicing factor TDP-43."  Nat. Struct. Mol. Biol. 20, 1443-1449 (2013).
PubMed: 24240615

Assembly members:

Assembly members:
TAR_DNA-BINDING_PROTEIN_43, polymer, 174 residues, 19955.5578 Da.
5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3', polymer, 12 residues, 3933.29822 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
TAR_DNA-BINDING_PROTEIN_43: GSHMASKTSDLIVLGLPWKT TEQDLKEYFSTFGEVLMVQV KKDLKTGHSKGFGFVRFTEY ETQVKVMSQRHMIDGRWCDC KLPNSKQSQDEPLRSRKVFV GRCTEDMTEDELREFFSQYG DVMDVFIPKPFRAFAFVTFA DDQIAQSLCGEDLIIKGISV HISNAEPKHNSNRQ
5'-R(*GP*UP*GP*UP*GP*AP*AP*UP*GP*AP*AP*UP)-3': GUGUGAAUGAAU

Data sets:
Data typeCount
13C chemical shifts864
15N chemical shifts182
1H chemical shifts1327
31P chemical shifts11

Additional metadata:

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  • Samples and Experiments
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Related Database Links:

UNP TADBP_HUMAN
PDB 4BS2
DBJ BAD96474 BAE87159 BAG35326 BAG58707 BAG61425
EMBL CAB43367 CAG38565 CAH92854 CAL37794
GB AAA70033 AAH71657 AAH95435 ABO32290 ABO32291
REF NP_001127597 NP_031401 XP_001102660 XP_002750326 XP_003274288
SP Q13148 Q5R5W2
AlphaFold Q96DJ0 Q13148 Q5R5W2

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