BMRB Entry 26513

Name: The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development
Published: 2015-02-24

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR26513

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry

Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

Select model:

I am color blind

Download raw data. Direct link to this display. Help

Title:

The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development

Deposition date:

2015-02-17

Original release date:

2015-02-24

Authors:

Stehle, Tanja; Sreeramulu, Sridhar; Lohr, Frank; Richter, Christian; Saxena, Krishna; Jonker, Hendrik; Schwalbe, Harald

Citation:

Citation: Stehle, Tanja; Sreeramulu, Sridhar; Lohr, Frank; Richter, Christian; Saxena, Krishna; Jonker, Hendrik; Schwalbe, Harald. "The Apo-structure of the Low Molecular Weight Protein-tyrosine Phosphatase A (MptpA) from Mycobacterium tuberculosis Allows for Better Target-specific Drug Development" J. Biol. Chem. 287, 34569-34582 (2012).
PubMed: 22888002

Assembly members:

Assembly members:
MptpA, polymer, 167 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Mycobacterium tuberculosis Taxonomy ID: 1773 Superkingdom: Bacteria Kingdom: not available Genus/species: Mycobacterium tuberculosis

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET16bTEV

Entity Sequences (FASTA):

Entity Sequences (FASTA):
MptpA: GAMGMSDPLHVTFVCTGNIC RSPMAEKMFAQQLRHRGLGD AVRVTSAGTGNWHVGSCADE RAAGVLRLHGYPTDHRAAQV GTEHLAADLLVALDRNHARL LRQLGVEAARVRMLRSFDPR SGTHALDVEDPYYGDHSDFE EVFAVIESALPGLHDWVDER LARNGPS

Data sets:

heteronucl_NOEs
- heteronuclear_noe_list_1
heteronucl_T1_relaxation
- heteronuclear_T1_list_1
heteronucl_T2_relaxation
- heteronuclear_T2_list_1
order_parameters
- order_parameter_list_1

Data type	Count
heteronuclear NOE values	132
T1 relaxation values	136
T2 relaxation values	133
order parameters	119

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
Hide all

Name	Sample	Sample state	Sample conditions
3D 1H, 1H-NOESY-15N TROSY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1
15N-{1H} NOE	sample_1	isotropic	sample_conditions_1

BMRB	18533 19361 19388
PDB	1U2P 1U2Q 2LUO
DBJ	BAH26529 BAL66249 BAQ06307 GAA45923
EMBL	CAL72239 CCC27315 CCC44588 CCC64828 CCE37704
GB	AAK46577 ABQ74015 ABR06594 ACT24805 AEB03885
REF	NP_216750 NP_855907 WP_003411510 WP_003899227 WP_015288274
SP	P65717 P9WIA0 P9WIA1
AlphaFold	P65717 P9WIA0 P9WIA1

BMRB Entry 26513

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links: