BMRB Entry 5211

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PDB ID: 1ka7
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR5211
MolProbity Validation Chart

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Title:
SAP/SH2D1A bound to peptide n-Y-c
Deposition date:
2001-11-15
Original release date:
2002-07-12
Authors:
Hwang, P.; Li, C.; Morra, M.; Lillywhite, J.; Muhandiram, D.; Gertler, F.; Terhorst, C.; Kay, L.; Pawson, T.; Forman-Kay, J.; Li, S.-C.
Citation:

Citation: Hwang, P.; Li, C.; Morra, M.; Lillywhite, J.; Muhandiram, D.; Gertler, F.; Terhorst, C.; Kay, L.; Pawson, T.; Forman-Kay, J.; Li, S.-C.. "A "three-pronged" Binding Mechanism for the SAP/SH2D1A SH2 Domain: Structural Basis and Relevance to the XLP Syndrome "  EMBO J. 21, 314-323 (2002).
PubMed: 11823424

Assembly members:

Assembly members:
SAP/SH2D1A, polymer, 128 residues, Formula weight is not available
peptide n-Y-c, polymer, 12 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
SAP/SH2D1A: MDAVAVYHGKISRETGEKLL LATGLDGSYLLRDSESVPGV YCLCVLYHGYIYTYRVSQTE TGSWSAETAPGVHKRYFRKI KNLISAFQKPDQGIVIPLQY PVEKKSSARSTQGTTGIRED PDVCLKAP
peptide n-Y-c: RKSLTIYAQVQK

Data sets:
Data typeCount
1H chemical shifts953
13C chemical shifts554
15N chemical shifts126

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1SH2 DOMAIN PROTEIN 1A1
2peptide n-Y-c2

Entities:

Entity 1, SH2 DOMAIN PROTEIN 1A 128 residues - Formula weight is not available

1   METASPALAVALALAVALTYRHISGLYLYS
2   ILESERARGGLUTHRGLYGLULYSLEULEU
3   LEUALATHRGLYLEUASPGLYSERTYRLEU
4   LEUARGASPSERGLUSERVALPROGLYVAL
5   TYRCYSLEUCYSVALLEUTYRHISGLYTYR
6   ILETYRTHRTYRARGVALSERGLNTHRGLU
7   THRGLYSERTRPSERALAGLUTHRALAPRO
8   GLYVALHISLYSARGTYRPHEARGLYSILE
9   LYSASNLEUILESERALAPHEGLNLYSPRO
10   ASPGLNGLYILEVALILEPROLEUGLNTYR
11   PROVALGLULYSLYSSERSERALAARGSER
12   THRGLNGLYTHRTHRGLYILEARGGLUASP
13   PROASPVALCYSLEULYSALAPRO

Entity 2, peptide n-Y-c 12 residues - Formula weight is not available

1   ARGLYSSERLEUTHRILETYRALAGLNVAL
2   GLNLYS

Related Database Links:

SWISS-PROT O60880
REF XP_865096 NP_002342 NP_001028009
GenBank AAK11578 AAH20732 AAC79712 AAC62631 AAC62630
EMBL CAG46840 CAG46828 CAA19222 CAA18777
DBJ BAG34852
PDB 1M27 1KA7 1KA6 1D4W 1D4T 1D1Z
BMRB 5212

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