BMRB Entry 7147

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PDB ID: 2h7b
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR7147
MolProbity Validation Chart

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Title:
The acute myeloid leukemia fusion protein AML1-ETO targets E-proteins via a PAH-like TAFH domain
Deposition date:
2006-05-18
Original release date:
2006-10-30
Authors:
Plevin, M.; Zhang, J.; Guo, C.; Roeder, R.; Ikura, M.
Citation:

Citation: Plevin, M.; Zhang, J.; Guo, C.; Roeder, R.; Ikura, M.. "The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain"  Proc. Natl. Acad. Sci. U.S.A. 103, 10242-10247 (2006).
PubMed: 16803958

Assembly members:

Assembly members:
Core-binding factor, ML1-ETO, polymer, 105 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
Core-binding factor, ML1-ETO: GSARQLSKLKRFLTTLQQFG NDISPEIGERVRTLVLGLVN STLTIEEFHSKLQEATNFPL RPFVIPFLKANLPLLQRELL HAARLAKQNPAQYLAQHEQL LLDAS

Data sets:
Data typeCount
13C chemical shifts326
15N chemical shifts96
1H chemical shifts768

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1Core-binding factor, ML1-ETO1

Entities:

Entity 1, Core-binding factor, ML1-ETO 105 residues - Formula weight is not available

1   GLYSERALAARGGLNLEUSERLYSLEULYS
2   ARGPHELEUTHRTHRLEUGLNGLNPHEGLY
3   ASNASPILESERPROGLUILEGLYGLUARG
4   VALARGTHRLEUVALLEUGLYLEUVALASN
5   SERTHRLEUTHRILEGLUGLUPHEHISSER
6   LYSLEUGLNGLUALATHRASNPHEPROLEU
7   ARGPROPHEVALILEPROPHELEULYSALA
8   ASNLEUPROLEULEUGLNARGGLULEULEU
9   HISALAALAARGLEUALALYSGLNASNPRO
10   ALAGLNTYRLEUALAGLNHISGLUGLNLEU
11   LEULEUASPALASER

Related Database Links:

BMRB 16467 7396
PDB 2H7B 2KNH 2PP4
DBJ BAA03089 BAA03247 BAA03558 BAA03559 BAA03560
EMBL CAA56311 CAF99400 CAG33073
GB AAB34819 AAB34820 AAC28931 AAC28932 AAC28933
REF NP_001070244 NP_001089065 NP_001101923 NP_001102127 NP_001104496
SP O75081 Q06455 Q61909
AlphaFold O75081 Q06455 Q61909

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