BMRB Entry 7242
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR7242
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Citation: Cunha, Luis; Kuti, Miklos; Bishop, David; Mezei, Mihaly; Zeng, Lei; Zhou, Ming-Ming; Desnick, Robert. "Human uroporphyrinogen III synthase: NMR-based mapping of the active site" Proteins 71, 855-873 (2008).
PubMed: 18004775
Assembly members:
Uroporphyrinogen-III-synthase, polymer, 266 residues, Formula weight is not available
Natural source: Common Name: Ulp1 yeast Taxonomy ID: 4932 Superkingdom: Eubacteria Kingdom: Fungi Genus/species: Saccharomyces cerevisiae
Experimental source: Production method: recombinant technology
Entity Sequences (FASTA):
Uroporphyrinogen-III-synthase: SMKVLLLKDAKEDDCGQDPY
IRELGLYGLEATLIPVLSFE
FLSLPSFSEKLSHPEDYGGL
IFTSPRAVEAAELCLEQNNK
TEVWERSLKEKWNAKSVYVV
GNATASLVSKIGLDTEGETC
GNAEKLAEYICSRESSALPL
LFPCGNLKREILPKALKDKG
IAMESITVYQTVAHPGIQGN
LNSYYSQQGVPASITFFSPS
GLTYSLKHIQELSGDNIDQI
KFAAIGPTTARALAAQGLPV
SCTAESPTPQALATGIRKAL
QPHGCC
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 789 |
| 15N chemical shifts | 241 |
| 1H chemical shifts | 1531 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | Uroporphyrinogen-III-Synthase (URO-synthase) | 1 |
Entities:
Entity 1, Uroporphyrinogen-III-Synthase (URO-synthase) 266 residues - Formula weight is not available
| 1 | SER | MET | LYS | VAL | LEU | LEU | LEU | LYS | ASP | ALA | ||||
| 2 | LYS | GLU | ASP | ASP | CYS | GLY | GLN | ASP | PRO | TYR | ||||
| 3 | ILE | ARG | GLU | LEU | GLY | LEU | TYR | GLY | LEU | GLU | ||||
| 4 | ALA | THR | LEU | ILE | PRO | VAL | LEU | SER | PHE | GLU | ||||
| 5 | PHE | LEU | SER | LEU | PRO | SER | PHE | SER | GLU | LYS | ||||
| 6 | LEU | SER | HIS | PRO | GLU | ASP | TYR | GLY | GLY | LEU | ||||
| 7 | ILE | PHE | THR | SER | PRO | ARG | ALA | VAL | GLU | ALA | ||||
| 8 | ALA | GLU | LEU | CYS | LEU | GLU | GLN | ASN | ASN | LYS | ||||
| 9 | THR | GLU | VAL | TRP | GLU | ARG | SER | LEU | LYS | GLU | ||||
| 10 | LYS | TRP | ASN | ALA | LYS | SER | VAL | TYR | VAL | VAL | ||||
| 11 | GLY | ASN | ALA | THR | ALA | SER | LEU | VAL | SER | LYS | ||||
| 12 | ILE | GLY | LEU | ASP | THR | GLU | GLY | GLU | THR | CYS | ||||
| 13 | GLY | ASN | ALA | GLU | LYS | LEU | ALA | GLU | TYR | ILE | ||||
| 14 | CYS | SER | ARG | GLU | SER | SER | ALA | LEU | PRO | LEU | ||||
| 15 | LEU | PHE | PRO | CYS | GLY | ASN | LEU | LYS | ARG | GLU | ||||
| 16 | ILE | LEU | PRO | LYS | ALA | LEU | LYS | ASP | LYS | GLY | ||||
| 17 | ILE | ALA | MET | GLU | SER | ILE | THR | VAL | TYR | GLN | ||||
| 18 | THR | VAL | ALA | HIS | PRO | GLY | ILE | GLN | GLY | ASN | ||||
| 19 | LEU | ASN | SER | TYR | TYR | SER | GLN | GLN | GLY | VAL | ||||
| 20 | PRO | ALA | SER | ILE | THR | PHE | PHE | SER | PRO | SER | ||||
| 21 | GLY | LEU | THR | TYR | SER | LEU | LYS | HIS | ILE | GLN | ||||
| 22 | GLU | LEU | SER | GLY | ASP | ASN | ILE | ASP | GLN | ILE | ||||
| 23 | LYS | PHE | ALA | ALA | ILE | GLY | PRO | THR | THR | ALA | ||||
| 24 | ARG | ALA | LEU | ALA | ALA | GLN | GLY | LEU | PRO | VAL | ||||
| 25 | SER | CYS | THR | ALA | GLU | SER | PRO | THR | PRO | GLN | ||||
| 26 | ALA | LEU | ALA | THR | GLY | ILE | ARG | LYS | ALA | LEU | ||||
| 27 | GLN | PRO | HIS | GLY | CYS | CYS |
Related Database Links:
| PDB | 1JR2 |
| DBJ | BAG37410 |
| GB | AAA60273 AAB21242 AAG36795 AAH02573 ABM82862 |
| REF | NP_000366 NP_001253711 XP_002756746 XP_002821304 XP_003277827 |
| SP | P10746 |
| AlphaFold | P10746 |
Download HSQC peak lists in one of the following formats:
CSV: Backbone
or all simulated peaks
SPARKY: Backbone
or all simulated peaks