BMRB Entry 7420

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PDB ID: 2jgw
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR7420
MolProbity Validation Chart

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Title:
STRUCTURE OF CCP MODULE 7 OF COMPLEMENT FACTOR H- THE AMD AT RISK VARIENT (402H)
Deposition date:
2008-03-06
Original release date:
2008-08-08
Authors:
Herbert, A.; Deakin, J.; Schmidt, C.; Blaum, B.; Egan, C.; Ferreira, V.; Pangburn, M.; Lyon, M.; Uhrin, D.; Barlow, P.
Citation:

Citation: Herbert, A.; Deakin, J.; Schmidt, C.; Blaum, B.; Egan, C.; Ferreira, V.; Pangburn, M.; Lyon, M.; Uhrin, D.; Barlow, P.. "Structure Shows Glycosaminoglycan- and Protein-Recognition Site in Factor H is Perturbed by Age-Related Macular Degeneration-Linked single nucleotide polymorphism"  J. Biol. Chem. 282, 18960-18968 (2007).
PubMed: 17360715

Assembly members:

Assembly members:
COMPLEMENT_FACTOR_H, polymer, 65 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: PICHIA PASTORIS   Vector: PPICZALPHAB

Entity Sequences (FASTA):

Entity Sequences (FASTA):
COMPLEMENT_FACTOR_H: EAAGLRKCYFPYLENGYNQN HGRKFVQGKSIDVACHPGYA LPKAQTTVTCMENGWSPTPR CIRVK

Data sets:
Data typeCount
13C chemical shifts275
15N chemical shifts68
1H chemical shifts439

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1COMPLEMENT FACTOR H1

Entities:

Entity 1, COMPLEMENT FACTOR H 65 residues - Formula weight is not available

1   GLUALAALAGLYLEUARGLYSCYSTYRPHE
2   PROTYRLEUGLUASNGLYTYRASNGLNASN
3   HISGLYARGLYSPHEVALGLNGLYLYSSER
4   ILEASPVALALACYSHISPROGLYTYRALA
5   LEUPROLYSALAGLNTHRTHRVALTHRCYS
6   METGLUASNGLYTRPSERPROTHRPROARG
7   CYSILEARGVALLYS

Related Database Links:

BMRB 7421
PDB 2IC4 2JGW 2JGX 2UWN 2V8E 2W80 2W81 4AYD 4AYE 4AYI 4AYM
EMBL CAA30403 CAB41739
GB AAA52013 AAH37285 AAI10644 ADZ15369 AHH32464
REF NP_001014975 XP_004028137

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