BMRB Entry 17103
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PDB ID: 2l1r
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR17103
MolProbity Validation Chart
NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry
Citation: Robertson, Ian; Sun, Yin-Biao; Li, Monica; Sykes, Brian. "A structural and functional perspective into the mechanism of Ca(2+)-sensitizers that target the cardiac troponin complex." J. Mol. Cell. Cardiol. 49, 1031-1041 (2010).
PubMed: 20801130
Assembly members:
cNTnC, polymer, 89 residues, 10070.361 Da.
cTnI(144-163), polymer, 20 residues, 2219.711 Da.
CA, non-polymer, 40.078 Da.
dfbp-o, non-polymer, 197.239 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET
Entity Sequences (FASTA):
cNTnC: MDDIYKAAVEQLTEEQKNEF
KAAFDIFVLGAEDGCISTKE
LGKVMRMLGQNPTPEELQEM
IDEVDEDGSGTVDFDEFLVM
MVRCMKDDS
cTnI(144-163): RRVRISADAMMQALLGARAK
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 266 |
| 15N chemical shifts | 85 |
| 1H chemical shifts | 665 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | cNTnC | 1 |
| 2 | cTnI | 2 |
| 3 | Calcium ion | 3 |
| 4 | 2',4'-difluoro (1,1'-biphenyl)-4-yloxy acetic acid | 4 |
Entities:
Entity 1, cNTnC 89 residues - 10070.361 Da.
| 1 | MET | ASP | ASP | ILE | TYR | LYS | ALA | ALA | VAL | GLU | ||||
| 2 | GLN | LEU | THR | GLU | GLU | GLN | LYS | ASN | GLU | PHE | ||||
| 3 | LYS | ALA | ALA | PHE | ASP | ILE | PHE | VAL | LEU | GLY | ||||
| 4 | ALA | GLU | ASP | GLY | CYS | ILE | SER | THR | LYS | GLU | ||||
| 5 | LEU | GLY | LYS | VAL | MET | ARG | MET | LEU | GLY | GLN | ||||
| 6 | ASN | PRO | THR | PRO | GLU | GLU | LEU | GLN | GLU | MET | ||||
| 7 | ILE | ASP | GLU | VAL | ASP | GLU | ASP | GLY | SER | GLY | ||||
| 8 | THR | VAL | ASP | PHE | ASP | GLU | PHE | LEU | VAL | MET | ||||
| 9 | MET | VAL | ARG | CYS | MET | LYS | ASP | ASP | SER |
Entity 2, cTnI 20 residues - 2219.711 Da.
| 1 | ARG | ARG | VAL | ARG | ILE | SER | ALA | ASP | ALA | MET | |
| 2 | MET | GLN | ALA | LEU | LEU | GLY | ALA | ARG | ALA | LYS |
Entity 3, Calcium ion - Ca - 40.078 Da.
| 1 | CA |
Entity 4, 2',4'-difluoro (1,1'-biphenyl)-4-yloxy acetic acid - C14 H9 O3 2F - 197.239 Da.
Related Database Links:
| BMRB | 15385 15388 15400 15427 16190 16752 19789 25034 25035 25120 25495 25034 25035 4824 5386 |
| PDB | 1AJ4 1AP4 1DTL 1J1D 1J1E 1LA0 1LXF 1MXL 1SPY 1WRK 1WRL 2CTN 2JT0 2JT3 2JT8 2JTZ 2JXL 2KFX 2KGB 2KRD 2L1R 2MKP 2MZP 3SD6 3SWB 4GJE 4GJF |
| DBJ | BAA02369 BAG36483 BAD97171 |
| EMBL | CAA30736 CAG46663 CAG46683 CAA38102 CAA62301 CAG46782 CAH57016 CAH92121 |
| GB | AAA36772 AAA37492 AAA37493 AAA48654 AAA49502 AAA16157 AAH96165 AAH96166 AAH96167 AAH99631 |
| PIR | S07450 TPHUCC |
| PRF | 1403394A 1510257A 750650A 1616225A |
| REF | NP_001029277 NP_001029523 NP_001123715 NP_001272501 NP_001291793 NP_000354 NP_001035607 NP_001092069 NP_001126240 XP_001085820 |
| SP | P02591 P05936 P09860 P19123 P63315 P08057 P19429 |
| TPG | DAA16908 DAA19371 |
| AlphaFold | P02591 P05936 P09860 P19123 P63315 P08057 P19429 |
Download HSQC peak lists in one of the following formats:
CSV: Backbone
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SPARKY: Backbone
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