BMRB Entry 17478

Name: Structure of cIAP1 CARD
Published: 2011-05-12

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PDB ID: 2l9m
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17478
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Structure of cIAP1 CARD

Deposition date:

2011-02-21

Original release date:

2011-05-12

Authors:

Hinds, Mark; Rautureau, Gilles; Day, Catherine

Citation:

Citation: Lopez, Juanita; John, Sidonie Wicky; Tenev, Tencho; Rautureau, Gilles; Hinds, Mark; Francalanci, Floriana; Wilson, Rebecca; Broemer, Meike; Santoro, Massimo; Day, Catherine; Meier, Pascal. "CARD-Mediated Autoinhibition of cIAP1's E3 Ligase Activity Suppresses Cell Proliferation and Migration." Mol. Cell 42, 569-583 (2011).
PubMed: 21549626

Assembly members:

Assembly members:
cIAP1-CARD, polymer, 132 residues, 15147.519 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEX:4T-3

Entity Sequences (FASTA):

Entity Sequences (FASTA):
cIAP1-CARD: GSHMLNAEDEKREEEKEKQA EEMASDDLSLIRKNRMALFQ QLTCVLPILDNLLKANVINK QEHDIIKQKTQIPLQARELI DTILVKGNAAANIFKNCLKE IDSTLYKNLFVDKNMKYIPT EDVSGLSLEEQL

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	156
15N chemical shifts	149
1H chemical shifts	165

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	cIAP1 CARD	1

Entities:

Entity 1, cIAP1 CARD 132 residues - 15147.519 Da.

residues 435-562 of BIRC2_HUMAN (uniprot) with 4 N-terminal vector derived residues residues, numbered 431-434

1

GLY

SER

HIS

MET

LEU

ASN

ALA

GLU

ASP

GLU

2

LYS

ARG

GLU

LYS

GLU

LYS

GLN

ALA

3

GLU

MET

ALA

SER

ASP

LEU

SER

LEU

4

ILE

ARG

LYS

ASN

ARG

MET

ALA

LEU

PHE

GLN

5

GLN

LEU

THR

CYS

VAL

LEU

PRO

ILE

LEU

ASP

6

ASN

LEU

LYS

ALA

ASN

VAL

ILE

ASN

LYS

7

GLN

GLU

HIS

ASP

ILE

LYS

GLN

LYS

THR

8

GLN

ILE

PRO

LEU

GLN

ALA

ARG

GLU

LEU

ILE

9

ASP

THR

ILE

LEU

VAL

LYS

GLY

ASN

ALA

10

ALA

ASN

ILE

PHE

LYS

ASN

CYS

LEU

LYS

GLU

11

ILE

ASP

SER

THR

LEU

TYR

LYS

ASN

LEU

PHE

12

VAL

ASP

LYS

ASN

MET

LYS

TYR

ILE

PRO

THR

13

GLU

ASP

VAL

SER

GLY

LEU

SER

LEU

GLU

14

GLN

LEU

Name	Sample	Sample state	Sample conditions
2D 1H-1H NOESY	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC	sample_2	isotropic	sample_conditions_1
3D HNCA	sample_3	isotropic	sample_conditions_1
3D HNCACB	sample_3	isotropic	sample_conditions_1
CC(CO)NH	sample_3	isotropic	sample_conditions_1
3D HNCO	sample_3	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_3	isotropic	sample_conditions_1
3D HNHA	sample_2	isotropic	sample_conditions_1
3D HNHB	sample_2	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_2	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_3	isotropic	sample_conditions_1

PDB	2L9M 3T6P
DBJ	BAG10600 BAG36235 BAG64288
EMBL	CAH91479
GB	AAC41942 AAC50372 AAC50508 AAH16174 AAH28578
PRF	2205253A
REF	NP_001157 NP_001243092 NP_001243095 NP_001248250 XP_001152534
SP	Q13490
AlphaFold	Q13490

BMRB Entry 17478

Additional metadata:

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Entities:

Samples:

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Software:

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