BMRB Entry 17680

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PDB ID: 2ldr
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR17680
MolProbity Validation Chart

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Title:
Solution structure of Helix-RING domain in the Tyr363 phosphorylated form.
Deposition date:
2011-06-01
Original release date:
2012-02-22
Authors:
Kumeta, Hiroyuki; Kobashigawa, Yoshihiro; Inagaki, Fuyuhiko
Citation:

Citation: Kobashigawa, Yoshihiro; Tomitaka, Akira; Kumeta, Hiroyuki; Noda, Nobuo; Yamaguchi, Masaya; Inagaki, Fuyuhiko. "Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b."  Proc. Natl. Acad. Sci. U.S.A. 108, 20579-20584 (2011).
PubMed: 22158902

Assembly members:

Assembly members:
CBLB-pY-H-RING, polymer, 82 residues, Formula weight is not available
ZN, non-polymer, 65.409 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pGBHPS

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CBLB-pY-H-RING: GPHMGSDHIKVTQEQYELXC EMGSTFQLCKICAENDKDVK IEPCGHLMCTSCLTAWQESD GQGCPFCRCEIKGTEPIIVD PF

Data sets:
Data typeCount
13C chemical shifts351
15N chemical shifts84
1H chemical shifts555

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1CBLB-pY-H-RING1
2Zinc_12
3Zinc_22

Entities:

Entity 1, CBLB-pY-H-RING 82 residues - Formula weight is not available

1   GLYPROHISMETGLYSERASPHISILELYS
2   VALTHRGLNGLUGLNTYRGLULEUPTRCYS
3   GLUMETGLYSERTHRPHEGLNLEUCYSLYS
4   ILECYSALAGLUASNASPLYSASPVALLYS
5   ILEGLUPROCYSGLYHISLEUMETCYSTHR
6   SERCYSLEUTHRALATRPGLNGLUSERASP
7   GLYGLNGLYCYSPROPHECYSARGCYSGLU
8   ILELYSGLYTHRGLUPROILEILEVALASP
9   PROPHE

Entity 2, Zinc_1 - Zn - 65.409 Da.

1   ZN

Related Database Links:

PDB 2LDR
EMBL CAF97501
GB AAB09292 AAB09293 AAH70806 EAW79751 EAW79752
REF NP_001084790 XP_004593274 XP_005465932 XP_005466101 XP_005466102
SP Q6NRE7
AlphaFold Q6NRE7

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