BMRB Entry 18501
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PDB ID: 2lty
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR18501
MolProbity Validation Chart
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NMR-STAR v3 text file.
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Citation: Aragon, Eric; Goerner, Nina; Xi, Qiaoran; Gomes, Tiago; Gao, Sheng; Massague, Joan; Macias, Maria. "Structural Basis for the Versatile Interactions of Smad7 with Regulator WW Domains in TGF-beta Pathways" Structure 20, 1726-1736 (2012).
PubMed: 22921829
Assembly members:
NEDD4LWW2, polymer, 34 residues, 3966.401 Da.
SMAD7, polymer, 15 residues, 1778.969 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: petM11
Entity Sequences (FASTA):
NEDD4LWW2: PGLPSGWEERKDAKGRTYYV
NHNNRTTTWTRPIG
SMAD7: ELESPPPPYSRYPMD
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 327 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | NEDD4LWW2 domain | 1 |
| 2 | Smad7 derived peptide | 2 |
Entities:
Entity 1, NEDD4LWW2 domain 34 residues - 3966.401 Da.
| 1 | PRO | GLY | LEU | PRO | SER | GLY | TRP | GLU | GLU | ARG | ||||
| 2 | LYS | ASP | ALA | LYS | GLY | ARG | THR | TYR | TYR | VAL | ||||
| 3 | ASN | HIS | ASN | ASN | ARG | THR | THR | THR | TRP | THR | ||||
| 4 | ARG | PRO | ILE | GLY |
Entity 2, Smad7 derived peptide 15 residues - 1778.969 Da.
| 1 | GLU | LEU | GLU | SER | PRO | PRO | PRO | PRO | TYR | SER | ||||
| 2 | ARG | TYR | PRO | MET | ASP |
Related Database Links:
| BMRB | 17544 16923 18500 18502 |
| PDB | 1WR4 2LB2 2LTY 2DJY 2KXQ 2LTX 2LTZ |
| GB | ABU94641 AAB81246 AAB81353 AAB81354 AAC25062 AAD41130 |
| DBJ | BAG11040 |
| EMBL | CAA04182 CAA04183 CAG12446 CDQ87305 CDQ93148 |
| REF | NP_001036125 NP_001153135 NP_001177750 NP_001231104 NP_001268265 |
| SP | O15105 O35253 O88406 |
| TPG | DAA15864 |
| AlphaFold | O15105 O35253 O88406 |