BMRB Entry 18967

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PDB ID: 2m3l
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR18967
MolProbity Validation Chart

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Title:
Solution structure of the C-terminal zinc-binding domain of HPV51 oncoprotein E6
Deposition date:
2013-01-21
Original release date:
2013-05-13
Authors:
Mischo, Andre; Ohlenschlager, Oliver; Gorlach, Matthias
Citation:

Citation: Mischo, Andre; Ohlenschlager, Oliver; Hortschansky, Peter; Ramachandran, Ramadurai; Gorlach, Matthias. "Structural insights into a wildtype domain of the oncoprotein E6 and its interaction with a PDZ domain"  PLOS One 8, e62584-e62584 (2013).
PubMed: 23638119

Assembly members:

Assembly members:
E6, polymer, 76 residues, 8951.278 Da.
ZINC ION, non-polymer, 65.409 Da.

Natural source:

Natural source:   Common Name: Human papillomavirus HPV   Taxonomy ID: 10566   Superkingdom: Viruses   Kingdom: not available   Genus/species: Human papillomavirus

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET15B

Entity Sequences (FASTA):

Entity Sequences (FASTA):
E6: GSHMSRSVYGTTLEAITKKS LYDLSIRCHRCQRPLGPEEK QKLVDEKKRFHEIAGRWTGQ CANCWQRTRQRNETQV

Data sets:
Data typeCount
13C chemical shifts337
15N chemical shifts80
1H chemical shifts527

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1E61
2ZINC ION2

Entities:

Entity 1, E6 76 residues - 8951.278 Da.

Residues 1-4 represent a non-native sequence originating from protease cleavage

1   GLYSERHISMETSERARGSERVALTYRGLY
2   THRTHRLEUGLUALAILETHRLYSLYSSER
3   LEUTYRASPLEUSERILEARGCYSHISARG
4   CYSGLNARGPROLEUGLYPROGLUGLULYS
5   GLNLYSLEUVALASPGLULYSLYSARGPHE
6   HISGLUILEALAGLYARGTRPTHRGLYGLN
7   CYSALAASNCYSTRPGLNARGTHRARGGLN
8   ARGASNGLUTHRGLNVAL

Entity 2, ZINC ION - Zn - 65.409 Da.

1   ZN

Related Database Links:

UniProtKB P26554
PDB 2M3L
EMBL CRH69907
GB ALJ32861 ALJ32868 ALJ32875 ALJ32882 ALJ32889
SP P26554
AlphaFold P26554

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