BMRB Entry 19033

Name: NMR structure of the SH3 domain of human RAS p21 protein activator (GTPase activating protein) 1
Published: 2013-03-21

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PDB ID: 2m51
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR19033
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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

NMR structure of the SH3 domain of human RAS p21 protein activator (GTPase activating protein) 1

Deposition date:

2013-02-12

Original release date:

2013-03-21

Authors:

Dutta, Samit; Serrano, Pedro; Geralt, Michael; Wuthrich, Kurt

Citation:

Citation: Dutta, Samit; Serrano, Pedro; Geralt, Michael; Wuthrich, Kurt. "NMR structure of the SH3 domain of human RAS p21 protein activator (GTPase activating protein) 1" .

Assembly members:

Assembly members:
RAS_GAP_1, polymer, 62 residues, 7268.292 Da.

Natural source:

Natural source: Common Name: Humans Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: SpeedET

Entity Sequences (FASTA):

Entity Sequences (FASTA):
RAS_GAP_1: GRRRVRAILPYTKVPDTDEI SFLKGDMFIVHNELEDGWMW VTNLRTDEQGLIVEDLVEEV GR

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	214
15N chemical shifts	69
1H chemical shifts	450

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	SH3 domain of human RAS GAP 1	1

Entities:

Entity 1, SH3 domain of human RAS GAP 1 62 residues - 7268.292 Da.

1

GLY

ARG

VAL

ARG

ALA

ILE

LEU

PRO

2

TYR

THR

LYS

VAL

PRO

ASP

THR

ASP

GLU

ILE

3

SER

PHE

LEU

LYS

GLY

ASP

MET

PHE

ILE

VAL

4

HIS

ASN

GLU

LEU

GLU

ASP

GLY

TRP

MET

TRP

5

VAL

THR

ASN

LEU

ARG

THR

ASP

GLU

GLN

GLY

6

LEU

ILE

VAL

GLU

ASP

LEU

VAL

GLU

VAL

7

GLY

ARG

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
4D-HACANH-APSY	sample_1	isotropic	sample_conditions_1
5D-CBCACONH-APSY	sample_1	isotropic	sample_conditions_1
5D-HACACONH-APSY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aliphatic	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY aromatic	sample_1	isotropic	sample_conditions_1

PDB	2J06 2GQI 4FSS 2J05 2GQI 2M51
DBJ	BAD92343 BAE21614 BAG35610 BAG62024 BAG62030
EMBL	CAA31122 CAH18488 CAH90505
GB	AAA16319 AAA35865 AAA52517 AAH13637 AAH20761
PRF	1411306A 1615347A 1615347B
REF	NP_001125265 NP_002881 NP_037267 NP_072179 NP_663427
SP	P09851 P20936 P50904
TPG	DAA27162
AlphaFold	P09851 P20936 P50904

BMRB Entry 19033

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

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