BMRB Entry 19824

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PDB ID: 4crp
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR19824
MolProbity Validation Chart

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Title:
Solution structure of a TrkAIg2 domain construct for use in drug discovery
Deposition date:
2014-02-28
Original release date:
2015-01-12
Authors:
Shoemark, D.; Fahey, M.; Williams, C.; Sessions, R.; Crump, Matthew; Allen-birt, S.; A., S.
Citation:

Citation: Allen, S.; Watson, J.; Shoemark, D.; Barua, N.; Patel, N.. "GDNF, NGF and BDNF as therapeutic options for neurodegeneration."  Pharmacology & Therapeutics ., .-..

Assembly members:

Assembly members:
HIGH_AFFINITY_NERVE_GROWTH_FACTOR_RECEPTOR, polymer, 107 residues, 11776.0322 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET24a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
HIGH_AFFINITY_NERVE_GROWTH_FACTOR_RECEPTOR: DDDDDVSFCASVQLHTAVEM HHWCIPFSVDGQPAPSLRWL FNGSVLNETSFIFTEFLEPA ANETVRHGCLRLNQPTHVNN GNYTLLAANPCGQASASIMA AFMDNPF

Data sets:
Data typeCount
13C chemical shifts441
15N chemical shifts113
1H chemical shifts690

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR1

Entities:

Entity 1, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR 107 residues - 11776.0322 Da.

1   ASPASPASPASPASPVALSERPHECYSALA
2   SERVALGLNLEUHISTHRALAVALGLUMET
3   HISHISTRPCYSILEPROPHESERVALASP
4   GLYGLNPROALAPROSERLEUARGTRPLEU
5   PHEASNGLYSERVALLEUASNGLUTHRSER
6   PHEILEPHETHRGLUPHELEUGLUPROALA
7   ALAASNGLUTHRVALARGHISGLYCYSLEU
8   ARGLEUASNGLNPROTHRHISVALASNASN
9   GLYASNTYRTHRLEULEUALAALAASNPRO
10   CYSGLYGLNALASERALASERILEMETALA
11   ALAPHEMETASPASNPROPHE

Related Database Links:

UNP NTRK1_HUMAN
PDB 1HE7 1WWA 1WWW 2IFG 4CRP
DBJ BAA34355 BAF83448 BAG35582
GB AAH62580 AAI36555 AAI44240 AHW56542 AHW56543
REF NP_001007793 NP_001012331 NP_002520 XP_001114243 XP_001145942
SP P04629
AlphaFold Q9UIU7 P04629

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