BMRB

Biological Magnetic Resonance Data Bank


A Repository for Data from NMR Spectroscopy on Proteins, Peptides, Nucleic Acids, and other Biomolecules
Member of WWPDB

BMRB Entry 25189

Title: Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DR 1*03 molecules induces antibody production and protection   PubMed: 15694510

Deposition date: 2014-09-01 Original release date: 2014-10-07

Authors: Cifuentes, Gladys; Salazar, Luz Mary; Vargas, Luis Eduardo; Parra, Carlos Alberto; Vanegas, Magnolia; Cortes, Jimena; Patarroyo, Manuel Elkin

Citation: Cifuentes, Gladys; Salazar, Luz Mary; Vargas, Luis Eduardo; Parra, Carlos Alberto; Vanegas, Magnolia; Cortes, Jimena; Patarroyo, Manuel Elkin. "Evidence supporting the hypothesis that specifically modifying a malaria peptide to fit into HLA-DRbeta1*03 molecules induces antibody production and protection"  Vaccine 23, 1579-1587 (2005).

Assembly members:
entity, polymer, 20 residues, 2446.658 Da.

Natural source:   Common Name: not available   Taxonomy ID: not available   Superkingdom: not available   Kingdom: not available   Genus/species: not available not available

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):
entity: YTNQNINISQERDLQKHGFH

Data sets:
Data typeCount
1H chemical shifts123

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 20 residues - 2446.658 Da.

1   TYRTHRASNGLNASNILEASNILESERGLN
2   GLUARGASPLEUGLNLYSHISGLYPHEHIS

Samples:

sample_1: DMSO 100%; Entity mM

sample_conditions_1: pH: 3.7; pressure: 1 atm; temperature: 295 K

Experiments:

NameSampleSample stateSample conditions
2D DQF-COSYsample_1isotropicsample_conditions_1
2D 1H-1H TOCSYsample_1isotropicsample_conditions_1
2D 1H-1H NOESYsample_1isotropicsample_conditions_1

Software:

InsightII, Accelrys Software Inc. - geometry optimization, refinement

NMR spectrometers:

  • Bruker DRX 600 MHz

Related Database Links:

PDB
EMBL CAA36756 CAD51055
GB AAA29600 AAA75179 AAF72186 AAK96216 ETW19326
REF XP_001349207
SP P19214
AlphaFold P19214