BMRB Entry 25595

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PDB ID: 2n2c
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full, LACS, SPARTA
BMRB Entry DOI: doi:10.13018/BMR25595
MolProbity Validation Chart

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Title:
NMR Structure of TDP-43 prion-like hydrophobic helix in DPC
Deposition date:
2015-05-06
Original release date:
2015-11-19
Authors:
Lim, Liang Zhong; Song, Jianxing
Citation:

Citation: Lim, Liang Zhong; Song, Jianxing. "ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically-disordered prion-like domain of TDP-43"  Plos Biology ., .-..

Assembly members:

Assembly members:
entity, polymer, 43 residues, 4336.979 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET28a

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity: MGGGMNFGAFSINPAMMAAA QAALQSSWGMMGMLASQQNQ SGP

Data sets:
Data typeCount
13C chemical shifts84
15N chemical shifts40
1H chemical shifts188

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity1

Entities:

Entity 1, entity 43 residues - 4336.979 Da.

1   METGLYGLYGLYMETASNPHEGLYALAPHE
2   SERILEASNPROALAMETMETALAALAALA
3   GLNALAALALEUGLNSERSERTRPGLYMET
4   METGLYMETLEUALASERGLNGLNASNGLN
5   SERGLYPRO

Related Database Links:

DBJ BAC27753 BAD96474 BAE21557 BAE26823 BAE32189
EMBL CAB43367 CAG31358 CAG38565 CAH92854 CAJ81570
GB AAA70033 AAH12873 AAH25544 AAH27772 AAH31126
REF NP_001026049 NP_001039950 NP_001127597 NP_001231687 NP_001231688
SP Q13148 Q28F51 Q5R5W2 Q5ZLN5 Q921F2
TPG DAA21291
AlphaFold Q13148 Q28F51 Q5R5W2 Q5ZLN5 Q921F2

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SPARKY: Backbone or all simulated peaks