BMRB Entry 26706

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR26706

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Title:
Backbone 13C, and 15 N Chemical Shift Assignments for fibrillar Islet Amyloid Polypeptide (IAPP)
Deposition date:
2015-11-12
Original release date:
2016-08-08
Authors:
Weirich, Franziska; Heise, Henrike; Mirecka, Ewa; Gremer, Lothar; Hoyer, Wolfgang; Schiefer, Stephanie
Citation:

Citation: Weirich, Franziska; Mirecka, Ewa; Schiefer, Stephanie; Gremer, Lothar; Hoyer, Wolfgang; Heise, Henrike. "Structural Characterization of Fibrils from Recombinant Human Islet Amyloid Polypeptide by Solid-State NMR: The Central FGAILS Segment Is Part of the beta-Sheet Core"  PLOS One 11, e0161243-e0161243 (2016).
PubMed: 27607147

Assembly members:

Assembly members:
IAPP, polymer, 37 residues, 3906.3 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET302/NT-His

Entity Sequences (FASTA):

Entity Sequences (FASTA):
IAPP: KCNTATCATQRLANFLVHSS NNFGAILSSTNVGSNTY

Data sets:
Data typeCount
13C chemical shifts109
15N chemical shifts37

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1recombinant fibrillar hIAPP1

Entities:

Entity 1, recombinant fibrillar hIAPP 37 residues - 3906.3 Da.

Full length human IAPP.

1   LYSCYSASNTHRALATHRCYSALATHRGLN
2   ARGLEUALAASNPHELEUVALHISSERSER
3   ASNASNPHEGLYALAILELEUSERSERTHR
4   ASNVALGLYSERASNTHRTYR