BMRB Entry 27549
Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR27549
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Citation: Tavella, Davide; Zitzewitz, Jill; Massi, Francesca. "Characterization of TDP-43 RRM2 Partially Folded States and Their Significance to ALS Pathogenesis." Biophys. J. 115, 1673-1680 (2018).
PubMed: 30309612
Assembly members:
TDP-43_RRM2, polymer, 76 residues, 8506.6182 Da.
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEX-6p1
Entity Sequences (FASTA):
TDP-43_RRM2: GPLGSRKVFVGRCTEDMTED
ELREFFSQYGDVMDVFIPKP
FRAFAFVTFADDQIAQSLCG
EDLIIKGISVHISNAE
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 119 |
| 15N chemical shifts | 68 |
| 1H chemical shifts | 68 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | TDP-43 RRM2 | 1 |
Entities:
Entity 1, TDP-43 RRM2 76 residues - 8506.6182 Da.
The first two residues (GP) are left after cleavege by PreScission protease. The following three residues (LGS) are required for cloning.
| 1 | GLY | PRO | LEU | GLY | SER | ARG | LYS | VAL | PHE | VAL | ||||
| 2 | GLY | ARG | CYS | THR | GLU | ASP | MET | THR | GLU | ASP | ||||
| 3 | GLU | LEU | ARG | GLU | PHE | PHE | SER | GLN | TYR | GLY | ||||
| 4 | ASP | VAL | MET | ASP | VAL | PHE | ILE | PRO | LYS | PRO | ||||
| 5 | PHE | ARG | ALA | PHE | ALA | PHE | VAL | THR | PHE | ALA | ||||
| 6 | ASP | ASP | GLN | ILE | ALA | GLN | SER | LEU | CYS | GLY | ||||
| 7 | GLU | ASP | LEU | ILE | ILE | LYS | GLY | ILE | SER | VAL | ||||
| 8 | HIS | ILE | SER | ASN | ALA | GLU |
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