BMRB Entry 30160

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PDB ID: 5t3m
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR30160
MolProbity Validation Chart

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Title:
Solution structure of a triple mutant of HwTx-IV - a potent blocker of Nav1.7
Deposition date:
2016-08-25
Original release date:
2017-08-31
Authors:
Rahnama, S.; Sharma, G.; Mobli, M.
Citation:

Citation: Rahnama, Sassan; Deuis, Jennifer; Cardoso, Fernanda; Ramanujam, Venkatraman; Lewis, Richard; Rash, Lachlan; King, Glenn; Vetter, Irina; Mobli, Mehdi. "The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant"  PLoS One 12, e0173551-e0173551 (2017).
PubMed: 28301520

Assembly members:

Assembly members:
entity_1, polymer, 35 residues, 3999.777 Da.

Natural source:

Natural source:   Common Name: Chinese bird spider   Taxonomy ID: 29017   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Haplopelma schmidti

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: PLIC-C

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GCLGIFKACNPSNDQCCKSS KLVCSRKTRWCKWQI

Data sets:
Data typeCount
13C chemical shifts153
15N chemical shifts41
1H chemical shifts245

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11

Entities:

Entity 1, entity_1 35 residues - 3999.777 Da.

1   GLYCYSLEUGLYILEPHELYSALACYSASN
2   PROSERASNASPGLNCYSCYSLYSSERSER
3   LYSLEUVALCYSSERARGLYSTHRARGTRP
4   CYSLYSTRPGLNILE

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