BMRB Entry 30771

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PDB ID: 6xr7
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR30771
MolProbity Validation Chart

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Title:
Abl isoform 1b inactive1 state
Deposition date:
2020-07-11
Original release date:
2020-10-05
Authors:
Xie, T.; Saleh, T.; Rossi, P.; Kalodimos, C.
Citation:

Citation: Xie, T.; Saleh, T.; Rossi, P.; Kalodimos, C.. "Conformational states dynamically populated by a kinase determine its function"  Science 370, eabc2754-eabc2754 (2020).
PubMed: 33004676

Assembly members:

Assembly members:
entity_1, polymer, 287 residues, 33180.898 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli BL21(DE3)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: SPNYDKWEMERTDITMKHKL GGGQYGEVYEGVWKKYSLTV AVKTLKEDTMEVEEFLKEAA VMKEIKHPNLVQLLGVCTRE PPFYIITEFMTYGNLLDYLR ECNRQEVNAVVLLYMATQIS SAMEYLEKKNFIHRDLAARN CLVGENHLVKVADFGLSRLM TGDTYTAHAGAKFPIKWTAP ESLAYNKFSIKSDVWAFGVL LWEIATYGMSPYPGIDLSQV YELLEKDYRMERPEGCPEKV YELMRACWQWNPSDRPSFAE IHQAFETMFQESSISDEVEK ELGKQGV

Data sets:
Data typeCount
13C chemical shifts142
1H chemical shifts402

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11

Entities:

Entity 1, unit_1 287 residues - 33180.898 Da.

1   SERPROASNTYRASPLYSTRPGLUMETGLU
2   ARGTHRASPILETHRMETLYSHISLYSLEU
3   GLYGLYGLYGLNTYRGLYGLUVALTYRGLU
4   GLYVALTRPLYSLYSTYRSERLEUTHRVAL
5   ALAVALLYSTHRLEULYSGLUASPTHRMET
6   GLUVALGLUGLUPHELEULYSGLUALAALA
7   VALMETLYSGLUILELYSHISPROASNLEU
8   VALGLNLEULEUGLYVALCYSTHRARGGLU
9   PROPROPHETYRILEILETHRGLUPHEMET
10   THRTYRGLYASNLEULEUASPTYRLEUARG
11   GLUCYSASNARGGLNGLUVALASNALAVAL
12   VALLEULEUTYRMETALATHRGLNILESER
13   SERALAMETGLUTYRLEUGLULYSLYSASN
14   PHEILEHISARGASPLEUALAALAARGASN
15   CYSLEUVALGLYGLUASNHISLEUVALLYS
16   VALALAASPPHEGLYLEUSERARGLEUMET
17   THRGLYASPTHRTYRTHRALAHISALAGLY
18   ALALYSPHEPROILELYSTRPTHRALAPRO
19   GLUSERLEUALATYRASNLYSPHESERILE
20   LYSSERASPVALTRPALAPHEGLYVALLEU
21   LEUTRPGLUILEALATHRTYRGLYMETSER
22   PROTYRPROGLYILEASPLEUSERGLNVAL
23   TYRGLULEULEUGLULYSASPTYRARGMET
24   GLUARGPROGLUGLYCYSPROGLULYSVAL
25   TYRGLULEUMETARGALACYSTRPGLNTRP
26   ASNPROSERASPARGPROSERPHEALAGLU
27   ILEHISGLNALAPHEGLUTHRMETPHEGLN
28   GLUSERSERILESERASPGLUVALGLULYS
29   GLULEUGLYLYSGLNGLYVAL