BMRB Entry 34081

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PDB ID: 5mrg
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_anomalous, AVS_full
BMRB Entry DOI: doi:10.13018/BMR34081
MolProbity Validation Chart

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Title:
Solution structure of TDP-43 (residues 1-102)
Deposition date:
2016-12-22
Original release date:
2017-06-02
Authors:
Mompean, M.; Romano, V.; Pantoja-Uceda, D.; Stuani, C.; Baralle, F.; Laurents, D.
Citation:

Citation: Mompean, M.; Romano, V.; Pantoja-Uceda, D.; Stuani, C.; Baralle, F.; Buratti, E.; Laurents, D.. "Point mutations in transactive response DNA-binding protein 43 (TDP-43)'s N-terminal domain compromise its stability, dimerization and functions"  J. Biol. Chem. 292, 11992-12006 (2017).
PubMed: 28566288

Assembly members:

Assembly members:
entity_1, polymer, 114 residues, 12674.207 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: MAGSHHHHHHGSMSEYIRVT EDENDEPIEIPSEDDGTVLL STVTAQFPGACGLRYRNPVS QCMRGVRLVEGILHAPDAGW GNLVYVVNYPKDNKRKMDET DASSAVKVKRAVQK

Data sets:
Data typeCount
15N chemical shifts1
1H chemical shifts584

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11

Entities:

Entity 1, entity_1 114 residues - 12674.207 Da.

1   METALAGLYSERHISHISHISHISHISHIS
2   GLYSERMETSERGLUTYRILEARGVALTHR
3   GLUASPGLUASNASPGLUPROILEGLUILE
4   PROSERGLUASPASPGLYTHRVALLEULEU
5   SERTHRVALTHRALAGLNPHEPROGLYALA
6   CYSGLYLEUARGTYRARGASNPROVALSER
7   GLNCYSMETARGGLYVALARGLEUVALGLU
8   GLYILELEUHISALAPROASPALAGLYTRP
9   GLYASNLEUVALTYRVALVALASNTYRPRO
10   LYSASPASNLYSARGLYSMETASPGLUTHR
11   ASPALASERSERALAVALLYSVALLYSARG
12   ALAVALGLNLYS

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