BMRB Entry 34466

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PDB ID: 6tr0
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR34466
MolProbity Validation Chart

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Title:
Solution structure of U2AF2 RRM1,2
Deposition date:
2019-12-17
Original release date:
2020-04-28
Authors:
Kang, H.; Sattler, M.
Citation:

Citation: Kang, H.; Sanchez-Rico, C.; Ebersberger, S.; Sutandy, F.; Busch, A.; Welte, T.; Stehle, R.; Hipp, C.; Schulz, L.; Buchbender, A.; Zarnack, K.; Konig, J.; Sattler, M.. "An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2."  Proc. Natl. Acad. Sci. U.S.A. 117, 7140-7149 (2020).
PubMed: 32188783

Assembly members:

Assembly members:
entity_1, polymer, 205 residues, 22342.486 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: AMVGSQMTRQARRLYVGNIP FGITEEAMMDFFNAQMRLGG LTQAPGNPVLAVQINQDKNF AFLEFRSVDETTQAMAFDGI IFQGQSLKIRRPHDYQPLPG MSENPSVYVPGVVSTVVPDS AHKLFIGGLPNYLNDDQVKE LLTSFGPLKAFNLVKDSATG LSKGYAFCEYVDINVTDQAI AGLNGMQLGDKKLLVQRASV GAKNA

Data sets:
Data typeCount
13C chemical shifts655
15N chemical shifts215
1H chemical shifts1370

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11

Entities:

Entity 1, unit_1 205 residues - 22342.486 Da.

1   ALAMETVALGLYSERGLNMETTHRARGGLN
2   ALAARGARGLEUTYRVALGLYASNILEPRO
3   PHEGLYILETHRGLUGLUALAMETMETASP
4   PHEPHEASNALAGLNMETARGLEUGLYGLY
5   LEUTHRGLNALAPROGLYASNPROVALLEU
6   ALAVALGLNILEASNGLNASPLYSASNPHE
7   ALAPHELEUGLUPHEARGSERVALASPGLU
8   THRTHRGLNALAMETALAPHEASPGLYILE
9   ILEPHEGLNGLYGLNSERLEULYSILEARG
10   ARGPROHISASPTYRGLNPROLEUPROGLY
11   METSERGLUASNPROSERVALTYRVALPRO
12   GLYVALVALSERTHRVALVALPROASPSER
13   ALAHISLYSLEUPHEILEGLYGLYLEUPRO
14   ASNTYRLEUASNASPASPGLNVALLYSGLU
15   LEULEUTHRSERPHEGLYPROLEULYSALA
16   PHEASNLEUVALLYSASPSERALATHRGLY
17   LEUSERLYSGLYTYRALAPHECYSGLUTYR
18   VALASPILEASNVALTHRASPGLNALAILE
19   ALAGLYLEUASNGLYMETGLNLEUGLYASP
20   LYSLYSLEULEUVALGLNARGALASERVAL
21   GLYALALYSASNALA

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