BMRB Entry 52401

Name: Tau Domain (272-441) Phosphorylated by GSK3 beta
Published: 2025-03-25

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR52401

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Tau Domain (272-441) Phosphorylated by GSK3 beta

Deposition date:

2024-04-15

Original release date:

2025-03-25

Authors:

El Hajjar, Lea; Boll, Emmanuelle; Cantrelle, Francois-Xavier; Smet-Nocca, Caroline

Citation:

Citation: El Hajjar, Lea; Boll, Emmanuelle; Cantrelle, Francois-Xavier; Bridot, Clarisse; Landrieu, Isabelle; Smet-Nocca, Caroline. "Effect of PHF-1 hyperphosphorylation on the seeding activity of C-terminal Tau fragments" Sci. Rep. 15, 9975-9975 (2025).
PubMed: 40121258

Assembly members:

Assembly members:
entity_1, polymer, 170 residues, 18176 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET15b

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GGKVQIINKKLDLSNVQSKC GSKDNIKHVPGGGSVQIVYK PVDLSKVTSKCGSLGNIHHK PGGGQVEVKSEKLDFKDRVQ SKIGSLDNITHVPGGGNKKI ETHKLTFRENAKAKTDHGAE IVYKXPVVXGDTXPRHLSNV SSTGSIDMVDSPQLATLADE VSASLAKQGL

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1
spectral_peak_list

Data type	Count
13C chemical shifts	468
15N chemical shifts	161
1H chemical shifts	313

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	R2Ct-P	1

Entities:

Entity 1, R2Ct-P 170 residues - 18176 Da.

X are phosphorylated Ser (pSer)

1	GLY	GLY	LYS	VAL	GLN	ILE	ILE	ASN	LYS	LYS
2	LEU	ASP	LEU	SER	ASN	VAL	GLN	SER	LYS	CYS
3	GLY	SER	LYS	ASP	ASN	ILE	LYS	HIS	VAL	PRO
4	GLY	GLY	GLY	SER	VAL	GLN	ILE	VAL	TYR	LYS
5	PRO	VAL	ASP	LEU	SER	LYS	VAL	THR	SER	LYS
6	CYS	GLY	SER	LEU	GLY	ASN	ILE	HIS	HIS	LYS
7	PRO	GLY	GLY	GLY	GLN	VAL	GLU	VAL	LYS	SER
8	GLU	LYS	LEU	ASP	PHE	LYS	ASP	ARG	VAL	GLN
9	SER	LYS	ILE	GLY	SER	LEU	ASP	ASN	ILE	THR
10	HIS	VAL	PRO	GLY	GLY	GLY	ASN	LYS	LYS	ILE
11	GLU	THR	HIS	LYS	LEU	THR	PHE	ARG	GLU	ASN
12	ALA	LYS	ALA	LYS	THR	ASP	HIS	GLY	ALA	GLU
13	ILE	VAL	TYR	LYS	SEP	PRO	VAL	VAL	SEP	GLY
14	ASP	THR	SEP	PRO	ARG	HIS	LEU	SER	ASN	VAL
15	SER	SER	THR	GLY	SER	ILE	ASP	MET	VAL	ASP
16	SER	PRO	GLN	LEU	ALA	THR	LEU	ALA	ASP	GLU
17	VAL	SER	ALA	SER	LEU	ALA	LYS	GLN	GLY	LEU

Name	Sample	Sample state	Sample conditions
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
206 (H[N[co[{CA\|ca[C]}]]])	sample_1	isotropic	sample_conditions_1
208 (H[N[ca[CO]]])	sample_1	isotropic	sample_conditions_1
211 (hNcaNH)	sample_1	isotropic	sample_conditions_1
2D 1H-15N HSQC/HMQC	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCACB	sample_1	isotropic	sample_conditions_1
10230 (CO[N])	sample_1	isotropic	sample_conditions_1
intra-HCAN	sample_1	isotropic	sample_conditions_1
225 (H{[N]+[HA]})	sample_1	isotropic	sample_conditions_1

BMRB Entry 52401

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	GLY	LYS	VAL	GLN	ILE	ILE	ASN	LYS	LYS
2	LEU	ASP	LEU	SER	ASN	VAL	GLN	SER	LYS	CYS
3	GLY	SER	LYS	ASP	ASN	ILE	LYS	HIS	VAL	PRO
4	GLY	GLY	GLY	SER	VAL	GLN	ILE	VAL	TYR	LYS
5	PRO	VAL	ASP	LEU	SER	LYS	VAL	THR	SER	LYS
6	CYS	GLY	SER	LEU	GLY	ASN	ILE	HIS	HIS	LYS
7	PRO	GLY	GLY	GLY	GLN	VAL	GLU	VAL	LYS	SER
8	GLU	LYS	LEU	ASP	PHE	LYS	ASP	ARG	VAL	GLN
9	SER	LYS	ILE	GLY	SER	LEU	ASP	ASN	ILE	THR
10	HIS	VAL	PRO	GLY	GLY	GLY	ASN	LYS	LYS	ILE
11	GLU	THR	HIS	LYS	LEU	THR	PHE	ARG	GLU	ASN
12	ALA	LYS	ALA	LYS	THR	ASP	HIS	GLY	ALA	GLU
13	ILE	VAL	TYR	LYS	SEP	PRO	VAL	VAL	SEP	GLY
14	ASP	THR	SEP	PRO	ARG	HIS	LEU	SER	ASN	VAL
15	SER	SER	THR	GLY	SER	ILE	ASP	MET	VAL	ASP
16	SER	PRO	GLN	LEU	ALA	THR	LEU	ALA	ASP	GLU
17	VAL	SER	ALA	SER	LEU	ALA	LYS	GLN	GLY	LEU

1	GLY	GLY	LYS	VAL	GLN	ILE	ILE	ASN	LYS	LYS
2	LEU	ASP	LEU	SER	ASN	VAL	GLN	SER	LYS	CYS
3	GLY	SER	LYS	ASP	ASN	ILE	LYS	HIS	VAL	PRO
4	GLY	GLY	GLY	SER	VAL	GLN	ILE	VAL	TYR	LYS
5	PRO	VAL	ASP	LEU	SER	LYS	VAL	THR	SER	LYS
6	CYS	GLY	SER	LEU	GLY	ASN	ILE	HIS	HIS	LYS
7	PRO	GLY	GLY	GLY	GLN	VAL	GLU	VAL	LYS	SER
8	GLU	LYS	LEU	ASP	PHE	LYS	ASP	ARG	VAL	GLN
9	SER	LYS	ILE	GLY	SER	LEU	ASP	ASN	ILE	THR
10	HIS	VAL	PRO	GLY	GLY	GLY	ASN	LYS	LYS	ILE
11	GLU	THR	HIS	LYS	LEU	THR	PHE	ARG	GLU	ASN
12	ALA	LYS	ALA	LYS	THR	ASP	HIS	GLY	ALA	GLU
13	ILE	VAL	TYR	LYS	SEP	PRO	VAL	VAL	SEP	GLY
14	ASP	THR	SEP	PRO	ARG	HIS	LEU	SER	ASN	VAL
15	SER	SER	THR	GLY	SER	ILE	ASP	MET	VAL	ASP
16	SER	PRO	GLN	LEU	ALA	THR	LEU	ALA	ASP	GLU
17	VAL	SER	ALA	SER	LEU	ALA	LYS	GLN	GLY	LEU

1	GLY	GLY	LYS	VAL	GLN	ILE	ILE	ASN	LYS	LYS
2	LEU	ASP	LEU	SER	ASN	VAL	GLN	SER	LYS	CYS
3	GLY	SER	LYS	ASP	ASN	ILE	LYS	HIS	VAL	PRO
4	GLY	GLY	GLY	SER	VAL	GLN	ILE	VAL	TYR	LYS
5	PRO	VAL	ASP	LEU	SER	LYS	VAL	THR	SER	LYS
6	CYS	GLY	SER	LEU	GLY	ASN	ILE	HIS	HIS	LYS
7	PRO	GLY	GLY	GLY	GLN	VAL	GLU	VAL	LYS	SER
8	GLU	LYS	LEU	ASP	PHE	LYS	ASP	ARG	VAL	GLN
9	SER	LYS	ILE	GLY	SER	LEU	ASP	ASN	ILE	THR
10	HIS	VAL	PRO	GLY	GLY	GLY	ASN	LYS	LYS	ILE
11	GLU	THR	HIS	LYS	LEU	THR	PHE	ARG	GLU	ASN
12	ALA	LYS	ALA	LYS	THR	ASP	HIS	GLY	ALA	GLU
13	ILE	VAL	TYR	LYS	SEP	PRO	VAL	VAL	SEP	GLY
14	ASP	THR	SEP	PRO	ARG	HIS	LEU	SER	ASN	VAL
15	SER	SER	THR	GLY	SER	ILE	ASP	MET	VAL	ASP
16	SER	PRO	GLN	LEU	ALA	THR	LEU	ALA	ASP	GLU
17	VAL	SER	ALA	SER	LEU	ALA	LYS	GLN	GLY	LEU