BMRB Entry 15053
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR15053
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Title: HPRP-173-195 SOLUTION STRUCTURE PubMed: 18563793
Deposition date: 2006-11-27 Original release date: 2007-02-01
Authors: Saviano, Gabriella; Tancredi, Teodorico
Citation: Ronga, Luisa; Palladino, Pasquale; Saviano, Gabriella; Tancredi, Teodorico; Benedetti, Ettore; Ragone, Raffaele; Rossi, Filomena. "Structural characterization of a neurotoxic threonine-rich peptide corresponding to the human prion protein alpha2-helical 180-195 segment, and comparison with full-length alpha2-helix-derived peptides" J. Pept. Sci. 14, 1096-1102 (2008).
Assembly members:
HPRP173195, polymer, 23 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
HPRP173195: NNFVHDCVNITIKQHTVTTT
TKG
- assigned_chemical_shifts
| Data type | Count |
| 1H chemical shifts | 133 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | prion protein fragment, alpha-2 helix | 1 |
Entities:
Entity 1, prion protein fragment, alpha-2 helix 23 residues - Formula weight is not available
| 1 | ASN | ASN | PHE | VAL | HIS | ASP | CYS | VAL | ASN | ILE | ||||
| 2 | THR | ILE | LYS | GLN | HIS | THR | VAL | THR | THR | THR | ||||
| 3 | THR | LYS | GLY |
Samples:
sample: HPRP1731951 – 2 mM; TRIFLUOROETHANOL-D2, [U-2H], 100%
sample_conditions_1: pH: 5.0; pressure: 1.0 atm; temperature: 300.0 K
Experiments:
| Name | Sample | Sample state | Sample conditions |
|---|---|---|---|
| NOESY | sample | isotropic | sample_conditions_1 |
| COSY | sample | isotropic | sample_conditions_1 |
| TOCSY | sample | isotropic | sample_conditions_1 |
| 15N-HSQC | sample | isotropic | sample_conditions_1 |
Software:
DYANA, P.GUNTERT - refinement
NMRView, B Johnson, One Moon Scientific - structure solution
NMR spectrometers:
- Bruker AVANCE 600 MHz
Related Database Links:
| BMRB | 15824 15845 16071 16075 16076 16077 16078 16079 16080 16184 16185 16722 16723 16743 17034 17081 17084 17087 17174 17213 17714 17756 17758 17780 17834 18426 18550 19268 4307 4379 4402 4434 4620 4641 4736 |
| PDB | |
| DBJ | BAA00011 BAA08790 BAD51981 BAE28320 BAE28693 |
| EMBL | CAA58442 CAG46836 CAG46869 CAH92912 CAJ18553 |
| GB | AAA19664 AAA37013 AAA37014 AAA37090 AAA37091 |
| PIR | B34759 |
| REF | NP_000302 NP_001009093 NP_001040617 NP_001073590 NP_001073591 |
| SP | P04156 P04273 P04925 P13852 P40245 |
| TPE | CAJ43808 |
| AlphaFold | P04273 P04925 P13852 P40245 P04156 |