BMRB Entry 15479

Name: 1H, 13C and 15N Resonance Assignment for the transmembrane and cytoplasmic domains of human CD4
Published: 2008-06-25

Chem Shift validation: AVS_full, LACS
BMRB Entry DOI: doi:10.13018/BMR15479

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Nicholas Rego and David Koes
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Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

1H, 13C and 15N Resonance Assignment for the transmembrane and cytoplasmic domains of human CD4

Deposition date:

2007-09-19

Original release date:

2008-06-25

Authors:

Wittlich, Marc; Koenig, Bernd; Hoffmann, Silke; Willbold, Dieter

Citation:

Citation: Wittlich, Marc; Koenig, Bernd; Hoffmann, Silke; Willbold, Dieter. "Structural characterization of the transmembrane and cytoplasmic domains of human CD4." Biochim. Biophys. Acta 1768, 2949-2960 (2007).
PubMed: 18035040

Assembly members:

Assembly members:
CD4_coreceptor_polypeptide, polymer, 70 residues, 7850.4 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pTKK19xb/ub

Entity Sequences (FASTA):

Entity Sequences (FASTA):
CD4_coreceptor_polypeptide: GPLVPRGSMALIVLGGVAGL LLFIGLGIFFSVRSRHRRRQ AERMSQIKRLLSEKKTSQSP HRFQKTHSPI

Data sets:

assigned_chemical_shifts
- assigned_chem_shift_list_1

Data type	Count
13C chemical shifts	329
15N chemical shifts	68
1H chemical shifts	529

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	CD4mut	1

Entities:

Entity 1, CD4mut 70 residues - 7850.4 Da.

Residues 1-8 proteolytic left-over, human CD4(372-433) C394S/C397S/C420S/C422S/C430H

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

Name	Sample	Sample state	Sample conditions
2D 1H-15N HSQC	sample_1	isotropic	sample_conditions_1
2D 1H-13C HSQC	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HNCA	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1
3D HCCH-COSY	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1

BMRB	16853
PDB	2KLU

BMRB Entry 15479

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links:

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE

1	GLY	PRO	LEU	VAL	PRO	ARG	GLY	SER	MET	ALA
2	LEU	ILE	VAL	LEU	GLY	GLY	VAL	ALA	GLY	LEU
3	LEU	LEU	PHE	ILE	GLY	LEU	GLY	ILE	PHE	PHE
4	SER	VAL	ARG	SER	ARG	HIS	ARG	ARG	ARG	GLN
5	ALA	GLU	ARG	MET	SER	GLN	ILE	LYS	ARG	LEU
6	LEU	SER	GLU	LYS	LYS	THR	SER	GLN	SER	PRO
7	HIS	ARG	PHE	GLN	LYS	THR	HIS	SER	PRO	ILE