BMRB Entry 17100

Name: Backbone Dynamics of the C-terminal SH2 Domain of the p85alpha Subunit of Phosphoinositide 3-kinase: Effect of Phosphotyrosine-Peptide Binding and Characterization of Slow Conformational Exchange Processes
Published: 2010-11-10

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17100

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Backbone Dynamics of the C-terminal SH2 Domain of the p85alpha Subunit of Phosphoinositide 3-kinase: Effect of Phosphotyrosine-Peptide Binding and Characterization of Slow Conformational Exchange Processes

Deposition date:

2010-08-02

Original release date:

2010-11-10

Authors:

Kristensen, Soren; Siegal, Gregg; Sankar, Andrew; Driscoll, Paul

Citation:

Citation: Kristensen, Soren; Siegal, Gregg; Sankar, Andrew; Driscoll, Paul. "Backbone Dynamics of the C-terminal SH2 Domain of the p85alpha Subunit of Phosphoinositide 3-Kinase: Effect of Slow Conformational Exchange Processes" J. Mol. Biol. 299, 771-788 (2000).
PubMed: 10835283

Assembly members:

Assembly members:
P85ALPHA, polymer, 112 residues, Formula weight is not available
PTR, non-polymer, 261.168 Da.

Natural source:

Natural source: Common Name: Cattle Taxonomy ID: 9913 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Bos taurus

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: na

Entity Sequences (FASTA):

Entity Sequences (FASTA):
P85ALPHA: MEDLPHHDEKTWNVGSSNRN KAENLLRGKRDGTFLVRESS KQGCYACSVVVDGEVKHCVI NKTATGYGFAEPYNLYSSLK ELVLHYQHTSLVQHNDSLNV TLAYPVYAQQRR

Data sets:

chemical_rates
- Chemical_rate_list

Data type	Count
kinetic rates	2

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	P85ALPHA	1
2	pY	2

Entities:

Entity 1, P85ALPHA 112 residues - Formula weight is not available

1

MET

GLU

ASP

LEU

PRO

HIS

ASP

GLU

LYS

2

THR

TRP

ASN

VAL

GLY

SER

ASN

ARG

ASN

3

LYS

ALA

GLU

ASN

LEU

ARG

GLY

LYS

ARG

4

ASP

GLY

THR

PHE

LEU

VAL

ARG

GLU

SER

5

LYS

GLN

GLY

CYS

TYR

ALA

CYS

SER

VAL

6

VAL

ASP

GLY

GLU

VAL

LYS

HIS

CYS

VAL

ILE

7

ASN

LYS

THR

ALA

THR

GLY

TYR

GLY

PHE

ALA

8

GLU

PRO

TYR

ASN

LEU

TYR

SER

LEU

LYS

9

GLU

LEU

VAL

LEU

HIS

TYR

GLN

HIS

THR

SER

10

LEU

VAL

GLN

HIS

ASN

ASP

SER

LEU

ASN

VAL

11

THR

LEU

ALA

TYR

PRO

VAL

TYR

ALA

GLN

12

ARG

Entity 2, pY - C9 H12 N O6 P - 261.168 Da.

1

PTR

PDB	1BFI 1BFJ 1H9O 1PIC 1QAD
DBJ	BAE37914

BMRB Entry 17100

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

Related Database Links: