BMRB Entry 17184

Name: Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity
Published: 2010-11-10

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR17184

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity

Deposition date:

2010-09-10

Original release date:

2010-11-10

Authors:

Nesmelova, Irina; Ermakova, Elena; Daragan, Vladimir; Pang, Mabel; Menendez, Margarita; Lagartera, Laura; Solis, Dolores; Baum, Linda; Mayo, Kevin

Citation:

Citation: Nesmelova, Irina; Ermakova, Elena; Daragan, Vladimir; Pang, Mabel; Menendez, Margarita; Lagartera, Laura; Solis, Dolores; Baum, Linda; Mayo, Kevin. "Lactose Binding to Galectin-1 Modulates Structural Dynamics, Increases Conformational Entropy, and Occurs with Apparent Negative Cooperativity" J. Mol. Biol. 397, 1209-1230 (2010).
PubMed: 20184898

Assembly members:

Assembly members:
gal1, polymer, 135 residues, Formula weight is not available
LAT, SACCHARIDE, 342.296 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
gal1: MACGLVASNLNLKPGECLRV RGEVAPDAKSFVLNLGKDSN NLCLHFNPRFNAHGDANTIV CNSKDGGAWGTEQREAVFPF QPGSVAEVCITFDQANLTVK LPDGYEFKFPNRLNLEAINY MAADGDFKIKCVAFD

Data sets:

binding constants
pKa values

Data type	Count
binding constants	2
pKa values	1

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Entity Assembly ID	Entity Name	Entity ID
1	gal1	1
2	LAT	2

BMRB	15800
PDB	1GZW 1W6M 1W6N 1W6O 1W6P 1W6Q 2KM2 3OY8 3OYW 3T2T 3W58 3W59
DBJ	BAC77389 BAG35095 BAG72608
EMBL	CAA32938 CAA33328 CAG30397 CAH92239 CAK54541
GB	AAA36170 AAB00777 AAH01693 AAH20675 AAP35421
PRF	1409286A 1713410A
REF	NP_001126310 NP_001135409 NP_001162098 NP_002296 XP_001162104
SP	P09382 Q5R7M1
AlphaFold	P09382 Q5R7M1

BMRB Entry 17184

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

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