BMRB Entry 18972
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PDB ID:
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR18972
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Title: SOLUTION STRUCTURE OF THE SOMATOSTATIN SST3 RECEPTOR ANTAGONIST TAU-CONOTOXIN CnVA PubMed: 23567999
Deposition date: 2013-01-24 Original release date: 2015-07-23
Authors: Petrel, C.; Hocking, Henry; Reynaud, M.; Favreau, P.; Paolini-bertrand, M.; Peigneur, S.; Upert, G.; Tytgat, J.; Gilles, N.; Hartley, O.; Boelens, R.; Stocklin, R.; Servent, D.; Servent, R.
Citation: Petrel, C.; Hocking, Henry; Reynaud, M.; Favreau, P.; Paolini-bertrand, M.; Peigneur, S.; Upert, G.; Tytgat, J.; Gilles, N.; Hartley, O.; Boelens, R.; Stocklin, R.; Servent, D.. "Identification, structural and pharmacological characterization of tau-CnVA, a conopeptide that selectively interacts with somatostatin sst3 receptor" Biochem. Pharmacol. 85, 1663-1671 (2013).
Assembly members:
TAU-CNVA, polymer, 15 residues, 1717.068 Da.
Natural source: Common Name: Conus consors Taxonomy ID: 101297 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Conus consors
Experimental source: Production method: chemical synthesis
Entity Sequences (FASTA):
TAU-CNVA: ECCHRQLLCCLRFVX
- assigned_chemical_shifts
Data type | Count |
13C chemical shifts | 51 |
1H chemical shifts | 103 |
Additional metadata:
Assembly:
Entity Assembly ID | Entity Name | Entity ID |
---|---|---|
1 | TAU-CNVA | 1 |
Entities:
Entity 1, TAU-CNVA 15 residues - 1717.068 Da.
1 | GLU | CYS | CYS | HIS | ARG | GLN | LEU | LEU | CYS | CYS | ||||
2 | LEU | ARG | PHE | VAL | NH2 |
Samples:
sample_1: TAU-CNVA, [U-13C; U-15N], 2.3 mM
sample_conditions_1: ionic strength: 0.0 mM; pH: 3.000; pressure: 1 atm; temperature: 295.000 K
Experiments:
Name | Sample | Sample state | Sample conditions |
---|---|---|---|
NOESY | sample_1 | solution | sample_conditions_1 |
DQF-COSY | sample_1 | solution | sample_conditions_1 |
e-COSY | sample_1 | solution | sample_conditions_1 |
TOCSY | sample_1 | solution | sample_conditions_1 |
Software:
AutoDep v4.3, PDBe - collection
CCPN_Analysis vany, CCPN - data analysis
CNS vany, BRUNGER,ADAMS,CLORE,DELANO,GROS,GROSSE- - chemical shift assignment
NMR spectrometers:
- Bruker Avance 500 MHz
Related Database Links:
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