BMRB Entry 25964

Title:
Structure of human islet amyloid polypeptide in complex with an engineered binding protein
Deposition date:
2016-01-26
Original release date:
2017-08-25
Authors:
Mirecka, Ewa; Feuerstein, Sophie; Stoldt, Matthias; Willbold, Dieter; Hoyer, Wolfgang
Citation:

Citation: Mirecka, Ewa; Feuerstein, Sophie; Gremer, Lothar; Schroder, Gunnar; Stoldt, Matthias; Willbold, Dieter; Hoyer, Wolfgang. "beta-Hairpin of Islet Amyloid Polypeptide Bound to an Aggregation Inhibitor"  Sci. Rep. 6, 33474-33474 (2016).
PubMed: 27641459

Assembly members:

Assembly members:
ISLET_AMYLOID_POLYPEPTIDE, polymer, 37 residues, 3908.322 Da.
HI18, polymer, 59 residues, 6531.2314 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET302

Entity Sequences (FASTA):

Data sets:
Data typeCount
13C chemical shifts354
15N chemical shifts121
1H chemical shifts565

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1ISLET AMYLOID POLYPEPTIDE1
2HI18, 12
3HI18, 22

Entities:

Entity 1, ISLET AMYLOID POLYPEPTIDE 37 residues - 3908.322 Da.

1   LYSCYSASNTHRALATHRCYSALATHRGLN
2   ARGLEUALAASNPHELEUVALHISSERSER
3   ASNASNPHEGLYALAILELEUSERSERTHR
4   ASNVALGLYSERASNTHRTYR

Entity 2, HI18, 1 59 residues - 6531.2314 Da.

1   VALASPASNLYSPHEASNLYSGLUMETGLU
2   SERALAGLYGLYGLUILEVALTYRLEUPRO
3   ASNLEUASNPROASPGLNLEUCYSALAPHE
4   ILEHISSERILEHISASPASPPROSERGLN
5   SERALAASNLEULEUALAGLUALALYSLYS
6   LEUASNASPALAGLNALAPROLYSTRP

Related Database Links:

UNP IAPP_HUMAN
PDB 5FSF
AlphaFold Q14598

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks