BMRB Entry 26628

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR26628

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Title:
assignment of HuR RRM1-2
Deposition date:
2015-08-08
Original release date:
2015-09-23
Authors:
Wang, Zhonghua
Citation:

Citation: Wang, Zhonghua; Bhattacharya, Akash; Ivanov, Dmitri. "Identification of small-molecule inhibitors of the HuR/RNA interaction using a fluorescence polarization screening assay followed by NMR validation."  PLoS One 10, e0138780-e0138780 (2015).
PubMed: 26390015

Assembly members:

Assembly members:
HuR, polymer, 193 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: Pet14b

Entity Sequences (FASTA):

Entity Sequences (FASTA):
HuR: MHHHHHHMSNGYEDHMAEDC RGDIGRTNLIVNYLPQNMTQ DELRSLFSSIGEVESAKLIR DKVAGHSLGYGFVNYVTAKD AERAINTLNGLRLQSKTIKV SYARPSSEVIKDANLYISGL PRTMTQKDVEDMFSRFGRII NSRVLVDQTTGLSRGVAFIR FDKRSEAEEAITSFNGHKPP GSSEPITVKFAAN

Data sets:
Data typeCount
15N chemical shifts153
1H chemical shifts153

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1RRM1-21

Entities:

Entity 1, RRM1-2 193 residues - Formula weight is not available

1   METHISHISHISHISHISHISMETSERASN
2   GLYTYRGLUASPHISMETALAGLUASPCYS
3   ARGGLYASPILEGLYARGTHRASNLEUILE
4   VALASNTYRLEUPROGLNASNMETTHRGLN
5   ASPGLULEUARGSERLEUPHESERSERILE
6   GLYGLUVALGLUSERALALYSLEUILEARG
7   ASPLYSVALALAGLYHISSERLEUGLYTYR
8   GLYPHEVALASNTYRVALTHRALALYSASP
9   ALAGLUARGALAILEASNTHRLEUASNGLY
10   LEUARGLEUGLNSERLYSTHRILELYSVAL
11   SERTYRALAARGPROSERSERGLUVALILE
12   LYSASPALAASNLEUTYRILESERGLYLEU
13   PROARGTHRMETTHRGLNLYSASPVALGLU
14   ASPMETPHESERARGPHEGLYARGILEILE
15   ASNSERARGVALLEUVALASPGLNTHRTHR
16   GLYLEUSERARGGLYVALALAPHEILEARG
17   PHEASPLYSARGSERGLUALAGLUGLUALA
18   ILETHRSERPHEASNGLYHISLYSPROPRO
19   GLYSERSERGLUPROILETHRVALLYSPHE
20   ALAALAASN

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