BMRB Entry 30826

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PDB ID: 7l2g
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR30826
MolProbity Validation Chart

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Title:
NMR solution structure of Nak1 from the Necator americanus hookworm
Deposition date:
2020-12-17
Original release date:
2021-10-22
Authors:
Smallwood, T.; Rosengren, K.; Clark, R.
Citation:

Citation: Smallwood, Taylor; Navarro, Severine; Cristofori-Armstrong, Ben; Watkins, Thomas; Tungatt, Katie; Ryan, Rachael; Haigh, Oscar; Lutzky, Viviana; Mulvenna, Jason; Rosengren, K Johan; Loukas, Alex; Miles, John; Clark, Richard. "Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo"  J. Biol. Chem. 297, 100834-100834 (2021).
PubMed: 34051231

Assembly members:

Assembly members:
entity_1, polymer, 40 residues, 4377.214 Da.

Natural source:

Natural source:   Common Name: Human hookworm   Taxonomy ID: 51031   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Necator americanus

Experimental source:

Experimental source:   Production method: chemical synthesis

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: CRDRIPQNVCEQMKKNGKCG DPRMSTIAELQCPKTCGKCX

Data sets:
Data typeCount
13C chemical shifts117
15N chemical shifts41
1H chemical shifts255

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11

Entities:

Entity 1, unit_1 40 residues - 4377.214 Da.

1   CYSARGASPARGILEPROGLNASNVALCYS
2   GLUGLNMETLYSLYSASNGLYLYSCYSGLY
3   ASPPROARGMETSERTHRILEALAGLULEU
4   GLNCYSPROLYSTHRCYSGLYLYSCYSNH2

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