BMRB Entry 34171

Title:
NMR derived model of the 5'-splice site of SMN2 in complex with the 5'-end of U1 snRNA
Deposition date:
2017-08-14
Original release date:
2017-08-25
Authors:
Campagne, S.; Clery, A.; Allain, F.
Citation:

Citation: Sivaramakrishnan, Manaswini; McCarthy, Kathleen; Campagne, Sebastien; Huber, Sylwia; Meier, Sonja; Augustin, Angelique; Heckel, Tobias; Meistermann, Helene; Hug, Melanie; Birrer, Pascale; Moursy, Ahmed; Khawaja, Sarah; Schmucki, Roland; Berntenis, Nikos; Giroud, Nicolas; Golling, Sabrina; Tzouros, Manuel; Banfai, Balazs; Duran-Pacheco, Gonzalo; Lamerz, Jens; Hsiu Liu, Ying; Luebbers, Thomas; Ratni, Hasane; Ebeling, Martin; Clery, Antoine; Paushkin, Sergey; Krainer, Adrian; Allain, Frederic H-T; Metzger, Friedrich. "Binding to SMN2 pre-mRNA-protein complex elicits specificity for small molecule splicing modifiers."  Nat. Commun. 8, 1476-1476 (2017).
PubMed: 29133793

Assembly members:

Assembly members:
entity_1, polymer, 11 residues, 3428.074 Da.
entity_2, polymer, 11 residues, 3547.162 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Homo sapiens

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: AUACXXACCUG
entity_2: GGAGUAAGUCU

Data sets:
Data typeCount
13C chemical shifts147
1H chemical shifts166

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1entity_11
2entity_22

Entities:

Entity 1, entity_1 11 residues - 3428.074 Da.

1   AUACPSUPSUACCU
2   G

Entity 2, entity_2 11 residues - 3547.162 Da.

1   GGAGUAAGUC
2   U