BMRB Entry 34536

Name: TFIIS N-terminal domain (TND) from human Elongin-A
Published: 2021-11-28

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PDB ID: 6zuz
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR34536
MolProbity Validation Chart

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

TFIIS N-terminal domain (TND) from human Elongin-A

Deposition date:

2020-07-23

Original release date:

2021-11-28

Authors:

Veverka, V.

Citation:

Citation: Cermakova, Katerina; Demeulemeester, Jonas; Lux, Vanda; Nedomova, Monika; Goldman, Seth; Smith, Eric; Srb, Pavel; Hexnerova, Rozalie; Fabry, Milan; Madlikova, Marcela; Horejsi, Magdalena; De Rijck, Jan; Debyser, Zeger; Adelman, Karen; Hodges, H Courtney; Veverka, Vaclav. "A ubiquitous disordered protein interaction module orchestrates transcription elongation" Science 374, 1113-1121 (2021).
PubMed: 34822292

Assembly members:

Assembly members:
entity_1, polymer, 90 residues, 9705.288 Da.

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: SNAASAMAAESALQVVEKLQ ARLAANPDPKKLLKYLKKLS TLPITVDILAETGVGKTVNS LRKHEHVGSFARDLVAQWKK LVPVERNAGS

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	395
15N chemical shifts	91
1H chemical shifts	654

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	unit_1	1

Entities:

Entity 1, unit_1 90 residues - 9705.288 Da.

1	SER	ASN	ALA	ALA	SER	ALA	MET	ALA	ALA	GLU
2	SER	ALA	LEU	GLN	VAL	VAL	GLU	LYS	LEU	GLN
3	ALA	ARG	LEU	ALA	ALA	ASN	PRO	ASP	PRO	LYS
4	LYS	LEU	LEU	LYS	TYR	LEU	LYS	LYS	LEU	SER
5	THR	LEU	PRO	ILE	THR	VAL	ASP	ILE	LEU	ALA
6	GLU	THR	GLY	VAL	GLY	LYS	THR	VAL	ASN	SER
7	LEU	ARG	LYS	HIS	GLU	HIS	VAL	GLY	SER	PHE
8	ALA	ARG	ASP	LEU	VAL	ALA	GLN	TRP	LYS	LYS
9	LEU	VAL	PRO	VAL	GLU	ARG	ASN	ALA	GLY	SER

Name	Sample	Sample state	Sample conditions
3D HNCACB	sample_1	isotropic	sample_conditions_1
3D CBCA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HNCO	sample_1	isotropic	sample_conditions_1
3D HBHA(CO)NH	sample_1	isotropic	sample_conditions_1
3D HCCH-TOCSY	sample_1	isotropic	sample_conditions_1
3D 1H-13C NOESY	sample_1	isotropic	sample_conditions_1
3D 1H-15N NOESY	sample_1	isotropic	sample_conditions_1

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SPARKY: Backbone or all simulated peaks

BMRB Entry 34536

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

1	SER	ASN	ALA	ALA	SER	ALA	MET	ALA	ALA	GLU
2	SER	ALA	LEU	GLN	VAL	VAL	GLU	LYS	LEU	GLN
3	ALA	ARG	LEU	ALA	ALA	ASN	PRO	ASP	PRO	LYS
4	LYS	LEU	LEU	LYS	TYR	LEU	LYS	LYS	LEU	SER
5	THR	LEU	PRO	ILE	THR	VAL	ASP	ILE	LEU	ALA
6	GLU	THR	GLY	VAL	GLY	LYS	THR	VAL	ASN	SER
7	LEU	ARG	LYS	HIS	GLU	HIS	VAL	GLY	SER	PHE
8	ALA	ARG	ASP	LEU	VAL	ALA	GLN	TRP	LYS	LYS
9	LEU	VAL	PRO	VAL	GLU	ARG	ASN	ALA	GLY	SER

1	SER	ASN	ALA	ALA	SER	ALA	MET	ALA	ALA	GLU
2	SER	ALA	LEU	GLN	VAL	VAL	GLU	LYS	LEU	GLN
3	ALA	ARG	LEU	ALA	ALA	ASN	PRO	ASP	PRO	LYS
4	LYS	LEU	LEU	LYS	TYR	LEU	LYS	LYS	LEU	SER
5	THR	LEU	PRO	ILE	THR	VAL	ASP	ILE	LEU	ALA
6	GLU	THR	GLY	VAL	GLY	LYS	THR	VAL	ASN	SER
7	LEU	ARG	LYS	HIS	GLU	HIS	VAL	GLY	SER	PHE
8	ALA	ARG	ASP	LEU	VAL	ALA	GLN	TRP	LYS	LYS
9	LEU	VAL	PRO	VAL	GLU	ARG	ASN	ALA	GLY	SER

1	SER	ASN	ALA	ALA	SER	ALA	MET	ALA	ALA	GLU
2	SER	ALA	LEU	GLN	VAL	VAL	GLU	LYS	LEU	GLN
3	ALA	ARG	LEU	ALA	ALA	ASN	PRO	ASP	PRO	LYS
4	LYS	LEU	LEU	LYS	TYR	LEU	LYS	LYS	LEU	SER
5	THR	LEU	PRO	ILE	THR	VAL	ASP	ILE	LEU	ALA
6	GLU	THR	GLY	VAL	GLY	LYS	THR	VAL	ASN	SER
7	LEU	ARG	LYS	HIS	GLU	HIS	VAL	GLY	SER	PHE
8	ALA	ARG	ASP	LEU	VAL	ALA	GLN	TRP	LYS	LYS
9	LEU	VAL	PRO	VAL	GLU	ARG	ASN	ALA	GLY	SER