BMRB Entry 34840

Click here to enlarge.

PDB ID: 8pxx
Entry in NMR Restraints Grid
Validation report in NRG-CING
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR34840
MolProbity Validation Chart

NMR-STAR file interactive viewer.
NMR-STAR v3 text file.
XML gzip file.
RDF gzip file.
All files associated with the entry

Title:
Structure of the WW domain tandem of PRPF40A in complex with SF1
Deposition date:
2023-07-24
Original release date:
2024-03-28
Authors:
Martinez-Lumbreras, S.; Sattler, M.
Citation:

Citation: Martinez-Lumbreras, Santiago; Trager, Lena; Mulorz, Miriam M.; Payr, Marco; Dikaya, Varvara; Hipp, Clara; Konig, Julian; Sattler, Michael. "Intramolecular autoinhibition regulates the selectivity of PRPF40A tandem WW domains for proline-rich motifs"  Nat. Commun. 15, 3888-3888 (2024).
PubMed: 38719828

Assembly members:

Assembly members:
entity_1, polymer, 99 residues, 11450.689 Da.
entity_2, polymer, 27 residues, 2414.689 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli BL21(DE3)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GAMGAKSMWTEHKSPDGRTY YYNTETKQSTWEKPDDLKTP AEQLLSKCPWKEYKSDSGKP YYYNSQTKESRWAKPKELED LEGYQNTIVAGSLITKSNL
entity_2: GAMSGSPPLPPGAPPPPPPP PPSGSGN

Data sets:
Data typeCount
13C chemical shifts425
15N chemical shifts117
1H chemical shifts831

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
  • Hide all

Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11
2unit_22

Entities:

Entity 1, unit_1 99 residues - 11450.689 Da.

1   GLYALAMETGLYALALYSSERMETTRPTHR
2   GLUHISLYSSERPROASPGLYARGTHRTYR
3   TYRTYRASNTHRGLUTHRLYSGLNSERTHR
4   TRPGLULYSPROASPASPLEULYSTHRPRO
5   ALAGLUGLNLEULEUSERLYSCYSPROTRP
6   LYSGLUTYRLYSSERASPSERGLYLYSPRO
7   TYRTYRTYRASNSERGLNTHRLYSGLUSER
8   ARGTRPALALYSPROLYSGLULEUGLUASP
9   LEUGLUGLYTYRGLNASNTHRILEVALALA
10   GLYSERLEUILETHRLYSSERASNLEU

Entity 2, unit_2 27 residues - 2414.689 Da.

1   GLYALAMETSERGLYSERPROPROLEUPRO
2   PROGLYALAPROPROPROPROPROPROPRO
3   PROPROSERGLYSERGLYASN

Download HSQC peak lists in one of the following formats:
CSV: Backbone or all simulated peaks
SPARKY: Backbone or all simulated peaks