BMRB Entry 34885

Title:
Solution structure of SMN-CX bound to the RNA helix formed upon SMN2 exon7 5'-splice site recognition
Deposition date:
2023-11-29
Original release date:
2024-02-28
Authors:
Malard, F.; Campagne, S.
Citation:

Citation: Malard, F.; Wolter, A.; Marquevielle, J.; Morvan, E.; Ecoutin, A.; Rudisser, S.; Allain, F.; Campagne, S.. "The diversity of splicing modifiers acting on A-1 bulged 5'-splice sites reveals rules for rational drug design"  Nucleic Acids Res. 52, 4124-4136 (2024).
PubMed: 38554107

Assembly members:

Assembly members:
entity_1, polymer, 11 residues, 3428.074 Da.
entity_2, polymer, 11 residues, 3547.162 Da.
entity_YB3, non-polymer, 376.430 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: synthetic construct

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: AUACXXACCUG
entity_2: GGAGUAAGUCU

Data sets:
Data typeCount
13C chemical shifts147
1H chemical shifts194

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1unit_11
2unit_22
3unit_33

Entities:

Entity 1, unit_1 11 residues - 3428.074 Da.

1   AUACPSUPSUACCU
2   G

Entity 2, unit_2 11 residues - 3547.162 Da.

1   GGAGUAAGUC
2   U

Entity 3, unit_3 - 376.430 Da.

1   YB3