BMRB Entry 50192

Name: Solid state NMR assignments for the patient FOR005 l-III immunoglobulin light chain variable domain amyloid fibrils
Published: 2020-09-19

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50192

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Nicholas Rego and David Koes
3Dmol.js: molecular visualization with WebGL
Bioinformatics (2015) 31 (8): 1322-1324 doi:10.1093/bioinformatics/btu829

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Title:

Solid state NMR assignments for the patient FOR005 l-III immunoglobulin light chain variable domain amyloid fibrils

Deposition date:

2020-02-07

Original release date:

2020-09-19

Authors:

Pradhan, Tejaswini; Annamalai, Karthikeyan; Sarkar, Riddhiman; Hegenbart, Ute; Schonland, Stefan; Fandrich, Marcus; Reif, Bernd

Citation:

Citation: Pradhan, Tejaswini; Annamalai, Karthikeyan; Sarkar, Riddhiman; Hegenbart, Ute; Schonland, Stefan; Fandrich, Marcus; Reif, Bernd. "Solid state NMR assignments of a human l-III immunoglobulin light chain amyloid fibrils" Biomol. NMR Assign. 15, 9-16 (2021).
PubMed: 32946005

Assembly members:

Assembly members:
entity_1, polymer, 110 residues, Formula weight is not available

Natural source:

Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens

Experimental source:

Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pET28(b+)

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GSSELTQDPAVSVALGQTVR ITCQGDSLRSYSASWYQQKP GQAPVLVIFRKSNRPSGIPD RFSGSSSGNTASLTITGAQA EDEADYYCNSRDSSANHQVF GGGTKLTVLG

Data sets:

assigned_chemical_shifts
- assigned_chemical_shifts_1

Data type	Count
13C chemical shifts	210
15N chemical shifts	51

Additional metadata:

Assembly
Samples and Experiments
Software
Spectrometers
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Assembly:

Entity Assembly ID	Entity Name	Entity ID
1	S3706_VL	1

Entities:

Entity 1, S3706_VL 110 residues - Formula weight is not available

1	GLY	SER	SER	GLU	LEU	THR	GLN	ASP	PRO	ALA
2	VAL	SER	VAL	ALA	LEU	GLY	GLN	THR	VAL	ARG
3	ILE	THR	CYS	GLN	GLY	ASP	SER	LEU	ARG	SER
4	TYR	SER	ALA	SER	TRP	TYR	GLN	GLN	LYS	PRO
5	GLY	GLN	ALA	PRO	VAL	LEU	VAL	ILE	PHE	ARG
6	LYS	SER	ASN	ARG	PRO	SER	GLY	ILE	PRO	ASP
7	ARG	PHE	SER	GLY	SER	SER	SER	GLY	ASN	THR
8	ALA	SER	LEU	THR	ILE	THR	GLY	ALA	GLN	ALA
9	GLU	ASP	GLU	ALA	ASP	TYR	TYR	CYS	ASN	SER
10	ARG	ASP	SER	SER	ALA	ASN	HIS	GLN	VAL	PHE
11	GLY	GLY	GLY	THR	LYS	LEU	THR	VAL	LEU	GLY

Name	Sample	Sample state	Sample conditions
2D PDSD	sample_1	fibrils	sample_conditions_1
2D DARR	sample_1	fibrils	sample_conditions_1
2D NCA	sample_1	fibrils	sample_conditions_1
2D NCACX	sample_1	fibrils	sample_conditions_1
2D NCOCX	sample_1	fibrils	sample_conditions_1
3D NCACX	sample_1	fibrils	sample_conditions_1
3D NCOCX	sample_1	fibrils	sample_conditions_1
3D CONCA	sample_1	fibrils	sample_conditions_1
3D CANCO	sample_1	fibrils	sample_conditions_1

BMRB Entry 50192

Additional metadata:

Assembly:

Entities:

Samples:

Experiments:

Software:

NMR spectrometers:

1	GLY	SER	SER	GLU	LEU	THR	GLN	ASP	PRO	ALA
2	VAL	SER	VAL	ALA	LEU	GLY	GLN	THR	VAL	ARG
3	ILE	THR	CYS	GLN	GLY	ASP	SER	LEU	ARG	SER
4	TYR	SER	ALA	SER	TRP	TYR	GLN	GLN	LYS	PRO
5	GLY	GLN	ALA	PRO	VAL	LEU	VAL	ILE	PHE	ARG
6	LYS	SER	ASN	ARG	PRO	SER	GLY	ILE	PRO	ASP
7	ARG	PHE	SER	GLY	SER	SER	SER	GLY	ASN	THR
8	ALA	SER	LEU	THR	ILE	THR	GLY	ALA	GLN	ALA
9	GLU	ASP	GLU	ALA	ASP	TYR	TYR	CYS	ASN	SER
10	ARG	ASP	SER	SER	ALA	ASN	HIS	GLN	VAL	PHE
11	GLY	GLY	GLY	THR	LYS	LEU	THR	VAL	LEU	GLY

1	GLY	SER	SER	GLU	LEU	THR	GLN	ASP	PRO	ALA
2	VAL	SER	VAL	ALA	LEU	GLY	GLN	THR	VAL	ARG
3	ILE	THR	CYS	GLN	GLY	ASP	SER	LEU	ARG	SER
4	TYR	SER	ALA	SER	TRP	TYR	GLN	GLN	LYS	PRO
5	GLY	GLN	ALA	PRO	VAL	LEU	VAL	ILE	PHE	ARG
6	LYS	SER	ASN	ARG	PRO	SER	GLY	ILE	PRO	ASP
7	ARG	PHE	SER	GLY	SER	SER	SER	GLY	ASN	THR
8	ALA	SER	LEU	THR	ILE	THR	GLY	ALA	GLN	ALA
9	GLU	ASP	GLU	ALA	ASP	TYR	TYR	CYS	ASN	SER
10	ARG	ASP	SER	SER	ALA	ASN	HIS	GLN	VAL	PHE
11	GLY	GLY	GLY	THR	LYS	LEU	THR	VAL	LEU	GLY

1	GLY	SER	SER	GLU	LEU	THR	GLN	ASP	PRO	ALA
2	VAL	SER	VAL	ALA	LEU	GLY	GLN	THR	VAL	ARG
3	ILE	THR	CYS	GLN	GLY	ASP	SER	LEU	ARG	SER
4	TYR	SER	ALA	SER	TRP	TYR	GLN	GLN	LYS	PRO
5	GLY	GLN	ALA	PRO	VAL	LEU	VAL	ILE	PHE	ARG
6	LYS	SER	ASN	ARG	PRO	SER	GLY	ILE	PRO	ASP
7	ARG	PHE	SER	GLY	SER	SER	SER	GLY	ASN	THR
8	ALA	SER	LEU	THR	ILE	THR	GLY	ALA	GLN	ALA
9	GLU	ASP	GLU	ALA	ASP	TYR	TYR	CYS	ASN	SER
10	ARG	ASP	SER	SER	ALA	ASN	HIS	GLN	VAL	PHE
11	GLY	GLY	GLY	THR	LYS	LEU	THR	VAL	LEU	GLY