BMRB Entry 50257

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50257

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Title:
hnRNPA2 1-189 bound to rA2RE11
Deposition date:
2020-05-01
Original release date:
2020-08-20
Authors:
Ryan, Veronica; Watters, Scott; Naik, Mandar; Fawzi, Nicolas
Citation:

Citation: Ryan, Veronica; Watters, Scott; Amaya, Joshua; Khatiwada, Balabhadra; Vendetti, Vincenzo; Naik, Mandar; Fawzi, Nicolas. "Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation"  Nucleic Acids Res. 48, 10542-10554 (2020).
PubMed: 32870271

Assembly members:

Assembly members:
entity_1, polymer, 189 residues, Formula weight is not available
entity_2, polymer, 11 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pJ411

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: MEREKEQFRKLFIGGLSFET TEESLRNYYEQWGKLTDCVV MRDPASKRSRGFGFVTFSSM AEVDAAMAARPHSIDGRVVE PKRAVAREESGKPGAHVTVK KLFVGGIKEDTEEHHLRDYF EEYGKIDTIEIITDRQSGKK RGFGFVTFDDHDPVDKIVLQ KYHTINGHNAEVRKALSRQE MQEVQSSRS
entity_2: GCCAAGGAGCC

Data sets:
Data typeCount
15N chemical shifts88
1H chemical shifts88

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1hnRNPA2 1-1891
2rA2RE112

Entities:

Entity 1, hnRNPA2 1-189 189 residues - Formula weight is not available

1   METGLUARGGLULYSGLUGLNPHEARGLYS
2   LEUPHEILEGLYGLYLEUSERPHEGLUTHR
3   THRGLUGLUSERLEUARGASNTYRTYRGLU
4   GLNTRPGLYLYSLEUTHRASPCYSVALVAL
5   METARGASPPROALASERLYSARGSERARG
6   GLYPHEGLYPHEVALTHRPHESERSERMET
7   ALAGLUVALASPALAALAMETALAALAARG
8   PROHISSERILEASPGLYARGVALVALGLU
9   PROLYSARGALAVALALAARGGLUGLUSER
10   GLYLYSPROGLYALAHISVALTHRVALLYS
11   LYSLEUPHEVALGLYGLYILELYSGLUASP
12   THRGLUGLUHISHISLEUARGASPTYRPHE
13   GLUGLUTYRGLYLYSILEASPTHRILEGLU
14   ILEILETHRASPARGGLNSERGLYLYSLYS
15   ARGGLYPHEGLYPHEVALTHRPHEASPASP
16   HISASPPROVALASPLYSILEVALLEUGLN
17   LYSTYRHISTHRILEASNGLYHISASNALA
18   GLUVALARGLYSALALEUSERARGGLNGLU
19   METGLNGLUVALGLNSERSERARGSER

Entity 2, rA2RE11 11 residues - Formula weight is not available

1   GCCAAGGAGC
2   C

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