BMRB Entry 50299

Title:
Identification of Phenothiazine Derivatives as UHM-Binding Inhibitors of Early Spliceosome Assembly
Deposition date:
2020-05-26
Original release date:
2020-09-28
Authors:
Jagtap, Pravin Kumar Ankush; Kubelka, Tomas; Soni, Komal; Sattler, Michael
Citation:

Citation: Jagtap, Pravin Kumar Ankush; Kubelka, Tomas; Soni, Komal; Will, Cindy; Garg, Divita; Sippel, Claudia; Kapp, Tobias; Potukuchi, Harish Kumar; Schorpp, Kenji; Hadian, Kamyar; Kessler, Horst; Luhrmann, Reinhard; Hausch, Felix; Bach, Thorsten; Sattler, Michael. "Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly"  Nat. Commun. 11, 5621-5621 (2020).
PubMed: 33159082

Assembly members:

Assembly members:
entity_1, polymer, 105 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pET-M

Data sets:
Data typeCount
13C chemical shifts63
15N chemical shifts100
1H chemical shifts216

Additional metadata:

  • Assembly
  • Samples and Experiments
  • Software
  • Spectrometers
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Assembly:

Entity Assembly IDEntity NameEntity ID
1SPF45 UHM domain1

Entities:

Entity 1, SPF45 UHM domain 105 residues - Formula weight is not available

1   GLYALAMETGLYLYSCYSPROTHRLYSVAL
2   VALLEULEUARGASNMETVALGLYALAGLY
3   GLUVALASPGLUASPLEUGLUVALGLUTHR
4   LYSGLUGLUCYSGLULYSTYRGLYLYSVAL
5   GLYLYSCYSVALILEPHEGLUILEPROGLY
6   ALAPROASPASPGLUALAVALARGILEPHE
7   LEUGLUPHEGLUARGVALGLUSERALAILE
8   LYSALAVALVALASPLEUASNGLYARGTYR
9   PHEGLYGLYARGVALVALLYSALACYSPHE
10   TYRASNLEUASPLYSPHEARGVALLEUASP
11   LEUALAGLUGLNVAL

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SPARKY: Backbone or all simulated peaks