BMRB Entry 50869
Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR50869
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NMR-STAR v3 text file.
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Citation: Linossi, Edmond; Li, Kunlun; Veggiani, Gianluca; Tan, Cyrus; Dehkhoda, Farhad; Hockings, Colin; Calleja, Dale; Keating, Narelle; Feltham, Rebecca; Brooks, Andrew; Li, Shawn; Sidhu, Sachdev; Babon, Jeffrey; Kershaw, Nadia; Nicholson, Sandra. "Identification of a novel exosite on the SOCS2-SH2 domain that enhances its binding to phosphorylated ligands" Nat. Commun. 12, 7032-7032 (2021).
PubMed: 34857742
Assembly members:
entity_1, polymer, 128 residues, Formula weight is not available
entity_2, polymer, 13 residues, Formula weight is not available
entity_3, polymer, 16 residues, Formula weight is not available
Natural source: Common Name: Human Taxonomy ID: 9606 Superkingdom: Eukaryota Kingdom: Metazoa Genus/species: Homo sapiens
Experimental source: Production method: recombinant technology Host organism: Escherichia coli Vector: pGEX-4T
Entity Sequences (FASTA):
entity_1: QAARLAKALRELGQTGWYWG
SMTVNEAKEKLKEAPEGTFL
IRDSSHSDYLLTISVKTSAG
PTNLRIEYQDGKFRLDSIIC
VKSKLKQFDSVVHLIDYYVQ
MCKDKRTGPEAPRNGTVHLY
LTKPLYTS
entity_2: PVPDXTSIHIVLM
entity_3: DIALQHLMDKWMAMQN
- assigned_chemical_shifts
| Data type | Count |
| 13C chemical shifts | 93 |
| 15N chemical shifts | 93 |
| 1H chemical shifts | 93 |
Additional metadata:
Assembly:
| Entity Assembly ID | Entity Name | Entity ID |
|---|---|---|
| 1 | SOCS2-SH2 | 1 |
| 2 | GHRpY | 2 |
| 3 | F3 | 3 |
Entities:
Entity 1, SOCS2-SH2 128 residues - Formula weight is not available
SH2 domain of human SOCS2. No SOCS-box.
| 1 | GLN | ALA | ALA | ARG | LEU | ALA | LYS | ALA | LEU | ARG | ||||
| 2 | GLU | LEU | GLY | GLN | THR | GLY | TRP | TYR | TRP | GLY | ||||
| 3 | SER | MET | THR | VAL | ASN | GLU | ALA | LYS | GLU | LYS | ||||
| 4 | LEU | LYS | GLU | ALA | PRO | GLU | GLY | THR | PHE | LEU | ||||
| 5 | ILE | ARG | ASP | SER | SER | HIS | SER | ASP | TYR | LEU | ||||
| 6 | LEU | THR | ILE | SER | VAL | LYS | THR | SER | ALA | GLY | ||||
| 7 | PRO | THR | ASN | LEU | ARG | ILE | GLU | TYR | GLN | ASP | ||||
| 8 | GLY | LYS | PHE | ARG | LEU | ASP | SER | ILE | ILE | CYS | ||||
| 9 | VAL | LYS | SER | LYS | LEU | LYS | GLN | PHE | ASP | SER | ||||
| 10 | VAL | VAL | HIS | LEU | ILE | ASP | TYR | TYR | VAL | GLN | ||||
| 11 | MET | CYS | LYS | ASP | LYS | ARG | THR | GLY | PRO | GLU | ||||
| 12 | ALA | PRO | ARG | ASN | GLY | THR | VAL | HIS | LEU | TYR | ||||
| 13 | LEU | THR | LYS | PRO | LEU | TYR | THR | SER |
Entity 2, GHRpY 13 residues - Formula weight is not available
| 1 | PRO | VAL | PRO | ASP | PTR | THR | SER | ILE | HIS | ILE | ||||
| 2 | VAL | LEU | MET |
Entity 3, F3 16 residues - Formula weight is not available
| 1 | ASP | ILE | ALA | LEU | GLN | HIS | LEU | MET | ASP | LYS | ||||
| 2 | TRP | MET | ALA | MET | GLN | ASN |
Download HSQC peak lists in one of the following formats:
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