BMRB Entry 51254

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR51254

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Title:
Solution NMR backbone chemical shift assignment for the extended xRRM2 domain of human La-related protein 7
Deposition date:
2021-12-22
Original release date:
2022-03-28
Authors:
Yang, Yuan; Eichhorn, Catherine; Hadjian, Tanya; Feigon, Juli
Citation:

Citation: Yang, Yuan; Liu, Shiheng; Egloff, Sylvain; Eichhorn, Catherine; Hadjian, Tanya; Zhen, James; Kiss, Tamas; Zhou, Z. Hong; Feigon, Juli. "Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP"  Mol. Cell 82, 1724-1736 (2022).
PubMed: 35320752

Assembly members:

Assembly members:
entity_1, polymer, 213 residues, 24357 Da.

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: recombinant technology   Host organism: Escherichia coli   Vector: pETDuet-1

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: GEEVIPLRVLSKSEWMDLKK EYLALQKASMASLKKTISQI KSESEMETDSGVPQNTGMKN EKTANREECRTQEKVNATGP QFVSGVIVKIISTEPLPGRK QVRDTLAAISEVLYVDLLEG DTECHARFKTPEDAQAVINA YTEINKKHCWKLEILSGDHE QRYWQKILVDRQAKLNQPRE KKRGTEKLITKAEKIRLAKT QQASKHIRFSEYD

Data sets:
Data typeCount
13C chemical shifts528
15N chemical shifts198
1H chemical shifts198

Additional metadata:

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Assembly:

Entity Assembly IDEntity NameEntity ID
1Larp7 extended xRRM2 domain1

Entities:

Entity 1, Larp7 extended xRRM2 domain 213 residues - 24357 Da.

1   GLYGLUGLUVALILEPROLEUARGVALLEU
2   SERLYSSERGLUTRPMETASPLEULYSLYS
3   GLUTYRLEUALALEUGLNLYSALASERMET
4   ALASERLEULYSLYSTHRILESERGLNILE
5   LYSSERGLUSERGLUMETGLUTHRASPSER
6   GLYVALPROGLNASNTHRGLYMETLYSASN
7   GLULYSTHRALAASNARGGLUGLUCYSARG
8   THRGLNGLULYSVALASNALATHRGLYPRO
9   GLNPHEVALSERGLYVALILEVALLYSILE
10   ILESERTHRGLUPROLEUPROGLYARGLYS
11   GLNVALARGASPTHRLEUALAALAILESER
12   GLUVALLEUTYRVALASPLEULEUGLUGLY
13   ASPTHRGLUCYSHISALAARGPHELYSTHR
14   PROGLUASPALAGLNALAVALILEASNALA
15   TYRTHRGLUILEASNLYSLYSHISCYSTRP
16   LYSLEUGLUILELEUSERGLYASPHISGLU
17   GLNARGTYRTRPGLNLYSILELEUVALASP
18   ARGGLNALALYSLEUASNGLNPROARGGLU
19   LYSLYSARGGLYTHRGLULYSLEUILETHR
20   LYSALAGLULYSILEARGLEUALALYSTHR
21   GLNGLNALASERLYSHISILEARGPHESER
22   GLUTYRASP

Download HSQC peak lists in one of the following formats:
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SPARKY: Backbone or all simulated peaks