BMRB Entry 51364

Chem Shift validation: AVS_full
BMRB Entry DOI: doi:10.13018/BMR51364

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Title:
TrkB-TM dimer
Deposition date:
2022-03-17
Original release date:
2023-06-05
Authors:
Kot, Erik; Goncharuk, Sergey; Mineev, Konstantin
Citation:

Citation: Moliner, Rafael; Girych, Mykhailo; Brunello, Cecilia; Kovaleva, Vera; Biojone, Caroline; Enkavi, Giray; Antenucci, Lina; Kot, Erik; Goncharuk, Sergey; Kaurinkoski, Katja; Kuutti, Mirjami; Fred, Senem; Elsila, Lauri; Sakson, Sven; Cannarozzo, Cecilia; Diniz, Cassiano; Seiffert, Nina; Rubiolo, Anna; Haapaniemi, Hele; Meshi, Elsa; Nagaeva, Elina; Ohman, Tiina; Rog, Tomasz; Kankuri, Esko; Vilar, Marcal; Varjosalo, Markku; Korpi, Esa; Permi, Perttu; Mineev, Konstantin; Saarma, Mart; Vattulainen, Ilpo; Casarotto, Plinio; Castren, Eero. "Psychedelics promote plasticity by directly binding to BDNF receptor TrkB"  Nat. Neurosci. 26, 1032-1041 (2023).

Assembly members:

Assembly members:
entity_1, polymer, 45 residues, Formula weight is not available

Natural source:

Natural source:   Common Name: Human   Taxonomy ID: 9606   Superkingdom: Eukaryota   Kingdom: Metazoa   Genus/species: Homo sapiens

Experimental source:

Experimental source:   Production method: cell free synthesis   Host organism: Escherichia coli   Vector: pGEMEX1

Entity Sequences (FASTA):

Entity Sequences (FASTA):
entity_1: MTDKTGREHLSVYAVVVIAS VVGFCLLVMLFLLKLARHSK FGMKG

Data sets:
Data typeCount
13C chemical shifts195
15N chemical shifts45
1H chemical shifts338

Additional metadata:

  • Assembly
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Assembly:

Entity Assembly IDEntity NameEntity ID
1TrkB-TM, chain 11
2TrkB-TM, chain 21

Entities:

Entity 1, TrkB-TM, chain 1 45 residues - Formula weight is not available

1   METTHRASPLYSTHRGLYARGGLUHISLEU
2   SERVALTYRALAVALVALVALILEALASER
3   VALVALGLYPHECYSLEULEUVALMETLEU
4   PHELEULEULYSLEUALAARGHISSERLYS
5   PHEGLYMETLYSGLY

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